Search Results - "Hansford, R G"

Mitochondrial biogenesis during cellular differentiation by Moyes, C D, Mathieu-Costello, O A, Tsuchiya, N, Filburn, C, Hansford, R G

“…Mitochondrial biogenesis was studied during differentiation of two immortalized cell lines (C2C12, 3T3) with enzyme measurements, Northern blots, and…”
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Mitochondrial membrane potential in single living adult rat cardiac myocytes exposed to anoxia or metabolic inhibition by Di Lisa, F, Blank, P S, Colonna, R, Gambassi, G, Silverman, H S, Stern, M D, Hansford, R G

“…1. The relation between mitochondrial membrane potential (delta psi m) and cell function was investigated in single adult rat cardiac myocytes during anoxia…”
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Age-associated increase in 8-oxo-deoxyguanosine glycosylase/AP lyase activity in rat mitochondria by Souza-Pinto, Nadja C., Croteau, Deborah L., Hudson, Edgar K., Hansford, Richard G., Bohr, Vilhelm A.

“…The mitochondrial theory of aging postulates that organisms age due to the accumulation of DNA damage and mutations in the multiple mitochondrial genomes,…”
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Measurement of mitochondrial free Ca2+ concentration in living single rat cardiac myocytes by Miyata, H, Silverman, H S, Sollott, S J, Lakatta, E G, Stern, M D, Hansford, R G

“…A technique that allows the continuous measurement of mitochondrial free Ca2+ ([Ca2+]m) in a single living cardiac myocyte is described. It involves the…”
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Age-associated change in mitochondrial DNA damage by Hudson, E K, Hogue, B A, Souza-Pinto, N C, Croteau, D L, Anson, R M, Bohr, V A, Hansford, R G

“…There is an age-associated decline in the mitochondrial function of the Wistar rat heart. Previous reports from this lab have shown a decrease in mitochondrial…”
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Mitochondrial calcium transporting pathways during hypoxia and reoxygenation in single rat cardiomyocytes by GRIFFITHS, E. J, OCAMPO, C. J, SAVAGE, J. S, RUTTER, G. A, HANSFORD, R. G, STERN, M. D, SILVERMAN, H. S

“…Mitochondrial [Ca2+] ([Ca2+]m) rises in parallel with cytosolic [Ca2+] ([Ca2+]c) following ATP-depletion rigor contracture induced by hypoxia in isolated…”
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Ryanodine releases calcium from sarcoplasmic reticulum in calcium-tolerant rat cardiac myocytes by Hansford, R G, Lakatta, E G

“…1. The hypothesis tested in this study is that ryanodine depletes sarcoplasmic reticulum (s.r.) Ca2+ loading in suspensions of single adult rat cardiac…”
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Influence of NAD-linked dehydrogenase activity on flux through oxidative phosphorylation by Moreno-Sánchez, R, Hogue, B A, Hansford, R G

“…1. We have examined systematically the relationship between the percentage reduction of cardiac mitochondrial NAD and the flux through oxidative…”
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Altered pyruvate dehydrogenase control and mitochondrial free Ca2+ in hearts of cardiomyopathic hamsters by Di Lisa, F, Fan, C Z, Gambassi, G, Hogue, B A, Kudryashova, I, Hansford, R G

“…The fraction of total pyruvate dehydrogenase in the active, dephosphorylated form is much lower in the glucose-perfused isolated hearts of two myopathic…”
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Modulation of calcium homeostasis in cultured rat aortic endothelial cells by intracellular acidification by Ziegelstein, R C, Cheng, L, Blank, P S, Spurgeon, H A, Lakatta, E G, Hansford, R G, Capogrossi, M C

“…Acidosis produces vasodilation in a process that may involve the vascular endothelium. Because synthesis and release of endothelium-derived vasodilatory…”
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Ethanol Acutely and Reversibly Suppresses Excitation-Contraction Coupling in Cardiac Myocytes by Danziger, Robert S, Sakai, Makoto, Capogrossi, Maurizio C, Spurgeon, Harold A, Hansford, Richard G, Lakatta, Edward G

“…We used adult rat cardiac myocytes to examine the acute effects of 0.1–5.0% (vol/vol) ethanol (ETOH) on 1) the cytosolic [Ca] (Cai) transient measured as the…”
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Relation between mitochondrial calcium transport and control of energy metabolism by Hansford, R G

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Volatile anesthetic effects on sarcoplasmic reticulum Ca content and sarcolemmal Ca flux in isolated rat cardiac cell suspensions by WHEELER, D. M, KATZ, A, RICE, R. T, HANSFORD, R. G

“…Cardiac cellular Ca metabolism is central to the control of the inotropic state of the heart and is altered in various ways by the volatile anesthetics…”
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Cytosolic pH measurements in single cardiac myocytes using carboxy-seminaphthorhodafluor-1 by Blank, P S, Silverman, H S, Chung, O Y, Hogue, B A, Stern, M D, Hansford, R G, Lakatta, E G, Capogrossi, M C

“…This study examines the use of carboxy-seminaphthorhodafluor-1 (C-SNARF-1) as an indicator of cytosolic pH in isolated rat cardiac myocytes. The emission…”
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Age-associated changes in mitochondrial mRNA expression and translation in the Wistar rat heart by Hudson, Edgar K, Tsuchiya, Naotaka, Hansford, Richard G

“…The purpose of this research is to determine possible causes and mechanisms involved in the age-associated decline in mitochondrial activity. We have focused…”
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Role of mitochondrial calcium transport in the control of substrate oxidation by Hansford, R G, Zorov, D

“…This paper reviews the model of the control of mitochondrial substrate oxidation by Ca2+ ions. The mechanism is the activation by Ca2+ of four mitochondrial…”
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Mitochondrial electron transport chain activities and DNA deletions in regions of the rat brain by Filburn, Charles R., Edris, Wade, Tamatani, Michio, Hogue, Barbara, Kudryashova, Irina, Hansford, Richard G.

“…Deletions in human mitochondrial DNA cause various mitochondrial myopathies and increase markedly with age in highly oxidative tissues, but exhibit a…”
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Effects of acidosis on resting cytosolic and mitochondrial Ca2+ in mammalian myocardium by GAMBASSI, G, HANSFORD, R. G, SOLLOTT, S. J, HOGUE, B. A, LAKATTA, E. G, CAPOGROSSI, M. C

“…Acidosis increases resting cytosolic [Ca2+], (Cai) of myocardial preparations; however, neither the Ca2+ sources for the increase in Cai nor the effect of…”
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Dependence of H2O2 formation by rat heart mitochondria on substrate availability and donor age by Hansford, R G, Hogue, B A, Mildaziene, V

“…We have examined the substrate specificity and inhibitor sensitivity of H2O2 formation by rat heart mitochondria. Active H2O2 production requires both a high…”
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PUFA and aging modulate cardiac mitochondrial membrane lipid composition and Ca2+ activation of PDH by Pepe, S, Tsuchiya, N, Lakatta, E G, Hansford, R G

“…Aberrations in cell Ca2+ homeostasis have been known to parallel both changes in membrane lipid composition and aging. Previous work has shown that the lowered…”
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