Search Results - "Hansen, Scott"

Lipid agonism: The PIP2 paradigm of ligand-gated ion channels by Hansen, Scott B.

“…The past decade, membrane signaling lipids emerged as major regulators of ion channel function. However, the molecular nature of lipid binding to ion channels…”
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Experimental Support for a Simplified Approach to CTRW Transport Models and Exploration of Parameter Interpretation by Hansen, Scott K.

“…We empirically test our earlier theoretical arguments about simplification of continuous‐time random walk (CTRW) solute transport models, namely that without…”
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Studies on the mechanism of general anesthesia by Pavel, Mahmud Arif, Petersen, E. Nicholas, Wang, Hao, Lerner, Richard A., Hansen, Scott B.

“…Inhaled anesthetics are a chemically diverse collection of hydrophobic molecules that robustly activate TWIK-related K⁺ channels (TREK-1) and reversibly induce…”
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The shared role of cholesterol in neuronal and peripheral inflammation by Hansen, Scott B., Wang, Hao

“…Neurodegeneration and its loss of cognitive function is associated with inflammation and an accumulation of lipids. In the periphery, cholesterol's uptake…”
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Impacts of Permeability Heterogeneity and Background Flow on Supercritical CO2 Dissolution in the Deep Subsurface by Hansen, Scott K., Tao, Yichen, Karra, Satish

“…Motivated by CO2 capture and sequestration (CCS) design considerations, we consider the coupled effects of permeability heterogeneity and background flow on…”
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Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2 by Hansen, Scott B., Tao, Xiao, MacKinnon, Roderick

“…Inward rectifier potassium channels The regulatory lipid phosphatidylinositol 4,5-bisphosphate (PIP 2 ) is the primary activator of inward rectifier K + (Kir)…”
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Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol by Wang, Hao, Kulas, Joshua A., Wang, Chao, Holtzman, David M., Ferris, Heather A., Hansen, Scott B.

“…Alzheimer’s disease (AD) is characterized by the presence of amyloid β (Aβ) plaques, tau tangles, inflammation, and loss of cognitive function. Genetic…”
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Tools for Understanding Nanoscale Lipid Regulation of Ion Channels by Robinson, Carol V., Rohacs, Tibor, Hansen, Scott B.

“…Anionic phospholipids are minor but prominent components of the plasma membrane that are necessary for ion channel function. Their persistence in bulk…”
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Getting in on the action: New tools to see SARS-CoV-2 infect a cell by Hansen, Scott B, Yuan, Zixuan

“…In this issue of Cell Chemical Biology, Miao et al. develop probes for live cell tracking of SARS-CoV-2. The probes reveal the endocytic pathway for viral…”
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Modeling Non‐Fickian Solute Transport Due to Mass Transfer and Physical Heterogeneity on Arbitrary Groundwater Velocity Fields by Hansen, Scott K., Berkowitz, Brian

“…We present a hybrid approach to groundwater transport modeling, “CTRW‐on‐a‐streamline,” that allows continuous‐time random walk (CTRW) particle tracking on…”
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Directly Generating Spatially Periodic, Heterogeneous Groundwater Flow Fields: A Finite Volume Approach by Zhou, Lian, Hansen, Scott K.

“…We present a finite volume approach for generating doubly‐periodic, 2D heterogeneous groundwater velocity fields, given an arbitrary hydraulic conductivity…”
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TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection by Chew, Glen M, Fujita, Tsuyoshi, Webb, Gabriela M, Burwitz, Benjamin J, Wu, Helen L, Reed, Jason S, Hammond, Katherine B, Clayton, Kiera L, Ishii, Naoto, Abdel-Mohsen, Mohamed, Liegler, Teri, Mitchell, Brooks I, Hecht, Frederick M, Ostrowski, Mario, Shikuma, Cecilia M, Hansen, Scott G, Maurer, Mark, Korman, Alan J, Deeks, Steven G, Sacha, Jonah B, Ndhlovu, Lishomwa C

“…HIV infection induces phenotypic and functional changes to CD8+ T cells defined by the coordinated upregulation of a series of negative checkpoint receptors…”
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VASP is a processive actin polymerase that requires monomeric actin for barbed end association by Hansen, Scott D., Mullins, R. Dyche

“…Ena/VASP proteins regulate the actin cytoskeleton during cell migration and morphogenesis and promote assembly of both filopodial and lamellipodial actin…”
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Cholesterol Regulation of Membrane Proteins Revealed by Two-Color Super-Resolution Imaging by Yuan, Zixuan, Hansen, Scott B

“…Cholesterol and phosphatidyl inositol 4,5-bisphosphate (PIP ) are hydrophobic molecules that regulate protein function in the plasma membrane of all cells. In…”
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A model selection approach to structural equation modelling: A critical evaluation and a road map for ecologists by Garrido, Mario, Hansen, Scott K., Yaari, Rami, Hawlena, Hadas

“…Structural equation modelling (SEM) can illuminate complex interaction networks of the sort found in ecology. However, selecting optimally complex,…”
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Aurora: A non-Fickian (and Fickian) particle tracking package for modeling groundwater contaminant transport with MODFLOW by Hansen, Scott K., Berkowitz, Brian

“…We introduce the Aurora software, which performs continuous time random walk (CTRW) particle tracking (PT) of dissolved contaminants on macroscopic groundwater…”
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Measurements and models of reactive transport in geological media by Berkowitz, Brian, Dror, Ishai, Hansen, Scott K., Scher, Harvey

“…Reactive chemical transport plays a key role in geological media across scales, from pore scale to aquifer scale. Systems can be altered by changes in solution…”
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Kinetic disruption of lipid rafts is a mechanosensor for phospholipase D by Petersen, E. Nicholas, Chung, Hae-Won, Nayebosadri, Arman, Hansen, Scott B.

“…The sensing of physical force, mechanosensation, underlies two of five human senses—touch and hearing. How transduction of force in a membrane occurs remains…”
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Molecular basis of product recognition during PIP5K-mediated production of PI(4,5)P2 with positive feedback by Duewell, Benjamin R., Faris, Katherine A., Hansen, Scott D.

“…The ability for cells to localize and activate peripheral membrane-binding proteins is critical for signal transduction. Ubiquitously important in these…”
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Programming cytomegalovirus as an HIV vaccine by Picker, Louis J., Lifson, Jeffrey D., Gale, Michael, Hansen, Scott G., Früh, Klaus

“…Non-human primate (NHP) cytomegaloviruses (CMVs) can be genetically modified to induce unconventional CD8+ T cell responses that target epitopes presented by…”
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