Non‐invasive imaging of retinal blood flow in myeloproliferative neoplasms

Purpose To study the circulation in the retinal vessels in patients with blood dyscrasia due to myeloproliferative neoplasms using non‐invasive retinal imaging. Methods Prospective consecutive case series of seven treatment‐naïve patients with chronic myeloid leukaemia (n = 2), polycythemia vera (n ...

Full description

Saved in:

Bibliographic Details
Published in:	Acta ophthalmologica (Oxford, England) Vol. 95; no. 2; pp. 146 - 152
Main Authors:	Willerslev, Anne, Hansen, Mathias M., Klefter, Oliver Niels, Bjerrum, Ole Weis, Hasselbalch, Hans C., Clemmensen, Stine N., Larsen, Michael, Munch, Inger Christine
Format:	Journal Article
Language:	English
Published:	England Wiley Subscription Services, Inc 01-03-2017
Subjects:	Adult Aged blood dyscrasia Female Follow-Up Studies Humans Male Middle Aged motion‐contrast imaging Myeloproliferative Disorders - diagnosis Myeloproliferative Disorders - physiopathology non‐invasive retinal imaging Ophthalmology Prospective Studies Regional Blood Flow - physiology retinal blood flow retinal oximetry Retinal Vessels - diagnostic imaging Retinal Vessels - physiopathology spectral‐domain optical coherence tomography Tomography, Optical Coherence - methods Young Adult spectral-domain optical coherence tomography retinal oximetry blood dyscrasia non-invasive retinal imaging retinal blood flow motion-contrast imaging
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Purpose To study the circulation in the retinal vessels in patients with blood dyscrasia due to myeloproliferative neoplasms using non‐invasive retinal imaging. Methods Prospective consecutive case series of seven treatment‐naïve patients with chronic myeloid leukaemia (n = 2), polycythemia vera (n = 4), essential thrombocytosis (n = 1) examined before and after cytoreductive treatment. We investigated retinal circulation with motion‐contrast imaging, retinal oximetry and spectral‐domain optical coherence tomography. Results Retinal venous blood velocity increased by 8.14% (CI95 3.67% to 12.6%, p = 0.004) and retinal arterial oxygen saturation increased by 7.23% (CI95 2.9% to 11.6%, p = 0.010) at follow‐up (mean 12 weeks, range 5–14 weeks) where complete haematological remission had been achieved by cytoreductive treatment. Abnormal optical coherence tomography reflectivity patterns were present at baseline in patients with chronic myeloid leukaemia and were replaced by normal patterns at follow‐up. Retinopathy, in the form of cotton‐wool spots and retinal haemorrhages, was found at presentation in the two patients with chronic myeloid leukaemia and in one patient with polycythemia vera. The retinopathy had resolved at follow‐up in all patients. Conclusion With non‐invasive retinal imaging, we were able to demonstrate increased retinal venous blood velocity, increased retinal arterial blood oxygenation and normalization of intravascular reflectivity patterns after successful treatment of myeloproliferative neoplasms. Larger prospective studies are needed to assess the prognostic value of these non‐invasive imaging methods in predicting circulatory complications in myeloproliferative neoplasms.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1755-375X 1755-3768
DOI:	10.1111/aos.13249