Search Results - "Hansen, Marc D H"

Opposing Roles of Zyxin/LPP ACTA Repeats and the LIM Domain Region in Cell-Cell Adhesion by Hansen, Marc D.H., Beckerle, Mary C.

“…Cadherins mediate cell-cell adhesion by linking cell junctions to actin networks. Although several actin regulatory systems have been implicated in cell-cell…”
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A natural product biflavonoid scaffold with anti-tryptase activity by Fazio, Nicholas F., Russell, Michael H., Flinders, Steven M., Gardner, Colin J., Webster, Jace B., Hansen, Marc D.H.

“…Tryptase is a serine protease that is released from mast cells during allergic responses. Tryptase inhibitors are being explored as treatments for allergic…”
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Isolation and identification of compounds from Kalanchoe pinnata having human alphaherpesvirus and vaccinia virus antiviral activity by Cryer, Matthew, Lane, Kyle, Greer, Mary, Cates, Rex, Burt, Scott, Andrus, Merritt, Zou, Jiping, Rogers, Paul, Hansen, Marc D. H., Burgado, Jillybeth, Satheshkumar, Panayampalli Subbian, Day, Craig W., Smee, Donald F., Johnson, F. Brent

“…Context: Kalanchoe pinnata (Lam.) Pers. (Crassulaceae) is a succulent plant that is known for its traditional antivirus and antibacterial usage. Objective:…”
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Plasma membrane ion fluxes and NFAT-dependent gene transcription contribute to c-met-induced epithelial scattering by Langford, Peter R, Keyes, Lance, Hansen, Marc D H

“…Hepatocyte growth factor (HGF) signaling drives epithelial cells to scatter by breaking cell-cell adhesions and causing them to migrate as solitary cells, a…”
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Zyxin-VASP interactions alter actin regulatory activity in zyxin-VASP complexes by Grange, Jacob, Moody, James, Ascione, Marc, Hansen, Marc

“…Cell-cell and cell-substrate adhesions are sites of dramatic actin rearrangements and where actin-membrane connections are tightly regulated. Zyxin-VASP…”
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Synthesis and biological evaluation of novel pyrazolo[1,5-a]pyrimidines: Discovery of a selective inhibitor of JAK1 JH2 pseudokinase and VPS34 by Singleton, Justin D., Dass, Reuben, Neubert, Nathaniel R., Smith, Rachel M., Webber, Zak, Hansen, Marc D.H., Peterson, Matt A.

“…[Display omitted] A series of novel 3,6-di-substituted or 3-substituted pyrazolo[1,5-a]pyrimidines were prepared via a microwave-assisted approach that…”
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Competitive enhancement of HGF-induced epithelial scattering by accessory growth factors by Chung, Jarom Y., Davis, John A., Price, Braden D., Staley, Davis M., Wagner, Mark V., Warner, Steven L., Bearss, David J., Hansen, Marc D.H.

“…HGF signaling induces epithelial cells to disassemble cadherin-based adhesion and increase cell motility and invasion, a process termed epithelial–mesenchymal…”
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Molecular Mechanism for Orienting Membrane and Actin Dynamics to Nascent Cell-Cell Contacts in Epithelial Cells by Hansen, Marc D H, Ehrlich, Jason S, Nelson, W James

“…The small GTPase Rac1 has been implicated in regulation of cell migration and cell-cell adhesion in epithelial cells. Little is known, however, about the…”
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Epithelial-Mesenchymal Transition in Metastatic Cancer Cell Populations Affects Tumor Dormancy in a Simple Mathematical Model by MacLean, Adam L, Harrington, Heather A, Stumpf, Michael P H, Hansen, Marc D H

“…Signaling from the c-Met receptor tyrosine kinase is associated with progression and metastasis of epithelial tumors. c-Met, the receptor for hepatocyte growth…”
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Selectivity and potency of natural product PIM kinase inhibitors identified by in silico docking by Russell, Michael H., Fazio, Nicholas F., Webster, Jace, Hansen, Marc D. H.

“…PIM3 (Proviral Integration site for Maloney murine leukemia virus kinase 3) is a proto-oncogene with serine/threonine kinase activity that prevents apoptosis,…”
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A cellular automaton based on plasma membrane turnover accurately recapitulates cell mechanics during epithelial scattering by Schmutz, Christian F., Hatton, Trey D., Blomfield, Michael P., Chandler, Benjamin D., Benedick, Trent C., Hansen, Marc D.H.

“…•A Cellular Potts Model recapitulating epithelial cell biology is developed.•The models suggests cell-cell adhesion is not reduced during epithelial…”
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Resistance mechanisms and cross-resistance for a pyridine-pyrimidine amide inhibitor of microtubule polymerization by Fox, J. Chancellor, Evans, Alex T., Blomfield, Michael P., Livingstone, Scout K., Tenney, Stephen R., Webster, Jace B., Perry, Katelyn, Hill, Jonathon T., Bikman, Benjamin T., Hansen, Marc D.H.

“…[Display omitted] Despite their clinical importance, drug resistance remains problematic for microtubule targeting drugs. D4-9-31, a novel microtubule…”
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Pyridine-pyrimidine amides that prevent HGF-induced epithelial scattering by two distinct mechanisms by Siddiqui-Jain, Adam, Hoj, Jacob P., Hargiss, J. Blade, Hoj, Taylor H., Payne, Carter J., Ritchie, Collin A., Herron, Steven R., Quinn, Colette, Schuler, Jeffrey T., Hansen, Marc D.H.

“…[Display omitted] Stimulation of cultured epithelial cells with scatter factor/hepatocyte growth factor (HGF) results in individual cells detaching and…”
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Control of Actin Dynamics by Allosteric Regulation of Actin Binding Proteins by Hansen, Marc D.H., Kwiatkowski, Adam V.

“…The regulated assembly and organization of actin filaments allows the cell to construct a large diversity of actin-based structures specifically suited to a…”
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Phosphorylation of VASP by AMPK alters actin binding and occurs at a novel site by Thomson, David M., Ascione, Marc P.A., Grange, Jacob, Nelson, Cody, Hansen, Marc D.H.

“…► AMPK phosphorylates VASP at a novel site, serine 322, and not at known PKA sites. ► Phosphorylation prevents VASP binding to actin filaments. ► Inhibition of…”
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Control of cell mechanics by RhoA and calcium fluxes during epithelial scattering by Haws, Hillary J., McNeil, Melissa A., Hansen, Marc D. H.

“…Epithelial tissues use adherens junctions to maintain tight interactions and coordinate cellular activities. Adherens junctions are remodeled during epithelial…”
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Cellular contractility changes are sufficient to drive epithelial scattering by Hoj, Jacob P., Davis, John A., Fullmer, Kendra E., Morrell, David J., Saguibo, Nicholas E., Schuler, Jeffrey T., Tuttle, Kevin J., Hansen, Marc D.H.

“…Epithelial scattering occurs when cells disassemble cell–cell junctions, allowing individual epithelial cells to act in a solitary manner. Epithelial…”
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Zyxin phosphorylation at serine 142 modulates the zyxin head–tail interaction to alter cell–cell adhesion by Call, Greg S., Chung, Jarom Y., Davis, John A., Price, Braden D., Primavera, Tyler S., Thomson, Nick C., Wagner, Mark V., Hansen, Marc D.H.

“…► A phosphomimetic mutation at zyxin serine 142 prevents the zyxin head–tail interaction. ► Zyxin mutations at serine 142 do not alter zyxin localization to…”
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Zyxin controls migration in epithelial-mesenchymal transition by mediating actin-membrane linkages at cell-cell junctions by Sperry, Rebecca Bakkevig, Bishop, Nicholas H., Bramwell, Jeremy J., Brodeur, Michael N., Carter, Matthew J., Fowler, Brent T., Lewis, Zachery B., Maxfield, Steve D., Staley, Davis M., Vellinga, Ryan M., Hansen, Marc D.H.

“…Development is punctuated by morphogenetic rearrangements of epithelial tissues, including detachment of motile cells during epithelial–mesenchymal transition…”
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Small Molecules Revealed in a Screen Targeting Epithelial Scattering Are Inhibitors of Microtubule Polymerization by Hoj, Taylor H, Robinson, Ryan J, Burton, Jason C, Densley-Ure, Rachel A, Olson, Tyler V, Williams, Logan K, Coward, Lori, Gorman, Greg, Hansen, Marc D H

“…Stimulation of cultured epithelial cells with scatter factor/hepatocyte growth factor (HGF) results in the detachment of cell-cell junctions and initiation of…”
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