Search Results - "Hansen, Jan N."

Ciliary Beating Compartmentalizes Cerebrospinal Fluid Flow in the Brain and Regulates Ventricular Development by Olstad, Emilie W., Ringers, Christa, Hansen, Jan N., Wens, Adinda, Brandt, Cecilia, Wachten, Dagmar, Yaksi, Emre, Jurisch-Yaksi, Nathalie

“…Motile cilia are miniature, propeller-like extensions, emanating from many cell types across the body. Their coordinated beating generates a directional fluid…”
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P2Y1 receptor blockade normalizes network dysfunction and cognition in an Alzheimer's disease model by Reichenbach, Nicole, Delekate, Andrea, Breithausen, Björn, Keppler, Kevin, Poll, Stefanie, Schulte, Theresa, Peter, Jan, Plescher, Monika, Hansen, Jan N, Blank, Nelli, Keller, Armin, Fuhrmann, Martin, Henneberger, Christian, Halle, Annett, Petzold, Gabor C

“…Astrocytic hyperactivity is an important contributor to neuronal-glial network dysfunction in Alzheimer's disease (AD). We have previously shown that astrocyte…”
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Cfap97d1 is important for flagellar axoneme maintenance and male mouse fertility by Oura, Seiya, Kazi, Samina, Savolainen, Audrey, Nozawa, Kaori, Castañeda, Julio, Yu, Zhifeng, Miyata, Haruhiko, Matzuk, Ryan M, Hansen, Jan N, Wachten, Dagmar, Matzuk, Martin M, Prunskaite-Hyyryläinen, Renata

“…The flagellum is essential for sperm motility and fertilization in vivo. The axoneme is the main component of the flagella, extending through its entire…”
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Multifocal imaging for precise, label-free tracking of fast biological processes in 3D by Hansen, Jan N., Gong, An, Wachten, Dagmar, Pascal, René, Turpin, Alex, Jikeli, Jan F., Kaupp, U. Benjamin, Alvarez, Luis

“…Many biological processes happen on a nano- to millimeter scale and within milliseconds. Established methods such as confocal microscopy are suitable for…”
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Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium by Hansen, Jan N, Kaiser, Fabian, Klausen, Christina, Stüven, Birthe, Chong, Raymond, Bönigk, Wolfgang, Mick, David U, Möglich, Andreas, Jurisch-Yaksi, Nathalie, Schmidt, Florian I, Wachten, Dagmar

“…Compartmentalization of cellular signaling forms the molecular basis of cellular behavior. The primary cilium constitutes a subcellular compartment that…”
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Nucleo-cytoplasmic shuttling of splicing factor SRSF1 is required for development and cilia function by Haward, Fiona, Maslon, Magdalena M, Yeyati, Patricia L, Bellora, Nicolas, Hansen, Jan N, Aitken, Stuart, Lawson, Jennifer, von Kriegsheim, Alex, Wachten, Dagmar, Mill, Pleasantine, Adams, Ian R, Caceres, Javier F

“…Shuttling RNA-binding proteins coordinate nuclear and cytoplasmic steps of gene expression. The SR family proteins regulate RNA splicing in the nucleus and a…”
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Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human by Schneider, Simon, Kovacevic, Andjela, Mayer, Michelle, Dicke, Ann-Kristin, Arévalo, Lena, Koser, Sophie A, Hansen, Jan N, Young, Samuel, Brenker, Christoph, Kliesch, Sabine, Wachten, Dagmar, Kirfel, Gregor, Strünker, Timo, Tüttelmann, Frank, Schorle, Hubert

“…Cylicins are testis-specific proteins, which are exclusively expressed during spermiogenesis. In mice and humans, two Cylicins, the gonosomal X-linked Cylicin…”
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Cannabinoid receptor 1 signalling modulates stress susceptibility and microglial responses to chronic social defeat stress by Beins, Eva C., Beiert, Thomas, Jenniches, Imke, Hansen, Jan N., Leidmaa, Este, Schrickel, Jan W., Zimmer, Andreas

“…Psychosocial stress is one of the main environmental factors contributing to the development of psychiatric disorders. In humans and rodents, chronic stress is…”
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SpermQ ⁻A Simple Analysis Software to Comprehensively Study Flagellar Beating and Sperm Steering by Hansen, Jan N, Rassmann, Sebastian, Jikeli, Jan F, Wachten, Dagmar

“…Motile cilia, also called flagella, are found across a broad range of species; some cilia propel prokaryotes and eukaryotic cells like sperm, while cilia on…”
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Morphometric Analyses of Macrophages by Hansen, Jan N

“…Cell morphology and motility drive the cellular capabilities to interact with the environment. For example, microglia, the longest known tissue-resident…”
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Molecular Mechanism Underlying the Action of Zona-pellucida Glycoproteins on Mouse Sperm by Balbach, Melanie, Hamzeh, Hussein, Jikeli, Jan F., Brenker, Christoph, Schiffer, Christian, Hansen, Jan N., Neugebauer, Pia, Trötschel, Christian, Jovine, Luca, Han, Ling, Florman, Harvey M., Kaupp, U. Benjamin, Strünker, Timo, Wachten, Dagmar

“…Mammalian oocytes are enveloped by the zona pellucida (ZP), an extracellular matrix of glycoproteins. In sperm, stimulation with ZP proteins evokes a rapid Ca…”
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Cyclic Nucleotide-Specific Optogenetics Highlights Compartmentalization of the Sperm Flagellum into cAMP Microdomains by Raju, Diana N, Hansen, Jan N, Rassmann, Sebastian, Stüven, Birthe, Jikeli, Jan F, Strünker, Timo, Körschen, Heinz G, Möglich, Andreas, Wachten, Dagmar

“…Inside the female genital tract, mammalian sperm undergo a maturation process called capacitation, which primes the sperm to navigate across the oviduct and…”
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Shedding light on the role of cAMP in mammalian sperm physiology by Balbach, Melanie, Beckert, Vera, Hansen, Jan N., Wachten, Dagmar

“…Mammalian fertilization relies on sperm finding the egg and penetrating the egg vestments. All steps in a sperm's lifetime crucially rely on changes in the…”
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Elucidating cyclic AMP signaling in subcellular domains with optogenetic tools and fluorescent biosensors by Klausen, Christina, Kaiser, Fabian, Stüven, Birthe, Hansen, Jan N, Wachten, Dagmar

“…The second messenger 3',5'-cyclic nucleoside adenosine monophosphate (cAMP) plays a key role in signal transduction across prokaryotes and eukaryotes. Cyclic…”
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Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A2A receptor by Carvalho, Kevin, Faivre, Emilie, Pietrowski, Marie J., Marques, Xavier, Gomez-Murcia, Victoria, Deleau, Aude, Huin, Vincent, Hansen, Jan N, Kozlov, Stanislav, Danis, Clément, Temido Ferreira, Mariana, Coelho, Joana, Mériaux, Céline, Eddarkaoui, Sabiha, Gras, Stéphanie Le, Dumoulin, Mélanie, Cellai, Lucrezia, Landrieu, Isabelle, Chern, Yijuang, Hamdane, Malika, Buée, Luc, Boutillier, Anne-Laurence, Levi, Sabine, Halle, Annett, Lopes, Luisa, Blum, David

“…© The Author(s) (2019). Published by Oxford University Press on behalf of the Guarantors of Brain. This is an Open Access article distributed under the terms…”
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AdipoQ—a simple, open-source software to quantify adipocyte morphology and function in tissues and in vitro by Sieckmann, Katharina, Winnerling, Nora, Huebecker, Mylene, Leyendecker, Philipp, Juliana Silva Ribeiro, Dalila, Gnad, Thorsten, Pfeifer, Alexander, Wachten, Dagmar, Hansen, Jan N.

“…AdipoQ, an open-source software implemented as ImageJ plugins, allows us to analyze adipocytes in tissue sections and in vitro after histological and/or…”
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Neural sphingosine 1‐phosphate accumulation activates microglia and links impaired autophagy and inflammation by Karunakaran, Indulekha, Alam, Shah, Jayagopi, Surendar, Frohberger, Stefan J., Hansen, Jan N., Kuehlwein, Janina, Hölbling, Benedikt V., Schumak, Beatrix, Hübner, Marc P., Gräler, Markus H., Halle, Annett, Echten‐Deckert, Gerhild

“…Microglia mediated responses to neuronal damage in the form of neuroinflammation is a common thread propagating neuropathology. In this study, we investigated…”
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Cannabinoid receptor 2 is necessary to induce toll‐like receptor‐mediated microglial activation by Reusch, Nico, Ravichandran, Kishore Aravind, Olabiyi, Bolanle Fatimat, Komorowska‐Müller, Joanna Agnieszka, Hansen, Jan N., Ulas, Thomas, Beyer, Marc, Zimmer, Andreas, Schmöle, Anne‐Caroline

“…The tight regulation of microglia activity is key for precise responses to potential threats, while uncontrolled and exacerbated microglial activity is…”
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Cannabinoid Receptor 2-Deficiency Ameliorates Disease Symptoms in a Mouse Model with Alzheimer's Disease-Like Pathology by Schmöle, Anne-Caroline, Lundt, Ramona, Toporowski, Gregor, Hansen, Jan N, Beins, Eva, Halle, Annett, Zimmer, Andreas

“…It is widely accepted that the endocannabinoid system (ECS) is a modulator of neuroinflammation associated with neurodegenerative disorders, including…”
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Human fertilization in vivo and in vitro requires the CatSper channel to initiate sperm hyperactivation by Young, Samuel, Schiffer, Christian, Wagner, Alice, Patz, Jannika, Potapenko, Anton, Herrmann, Leonie, Nordhoff, Verena, Pock, Tim, Krallmann, Claudia, Stallmeyer, Birgit, Röpke, Albrecht, Kierzek, Michelina, Biagioni, Cristina, Wang, Tao, Haalck, Lars, Deuster, Dirk, Hansen, Jan N, Wachten, Dagmar, Risse, Benjamin, Behre, Hermann M, Schlatt, Stefan, Kliesch, Sabine, Tüttelmann, Frank, Brenker, Christoph, Strünker, Timo

“…The infertility of many couples rests on an enigmatic dysfunction of the man's sperm. To gain insight into the underlying pathomechanisms, we assessed the…”
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