Search Results - "Hansen, Fynn M."

Data-independent acquisition method for ubiquitinome analysis reveals regulation of circadian biology by Hansen, Fynn M., Tanzer, Maria C., Brüning, Franziska, Bludau, Isabell, Stafford, Che, Schulman, Brenda A., Robles, Maria S., Karayel, Ozge, Mann, Matthias

“…Protein ubiquitination is involved in virtually all cellular processes. Enrichment strategies employing antibodies targeting ubiquitin-derived diGly remnants…”
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The structural context of posttranslational modifications at a proteome-wide scale by Bludau, Isabell, Willems, Sander, Zeng, Wen-Feng, Strauss, Maximilian T, Hansen, Fynn M, Tanzer, Maria C, Karayel, Ozge, Schulman, Brenda A, Mann, Matthias

“…The recent revolution in computational protein structure prediction provides folding models for entire proteomes, which can now be integrated with large-scale…”
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Interconversion between Anticipatory and Active GID E3 Ubiquitin Ligase Conformations via Metabolically Driven Substrate Receptor Assembly by Qiao, Shuai, Langlois, Christine R., Chrustowicz, Jakub, Sherpa, Dawafuti, Karayel, Ozge, Hansen, Fynn M., Beier, Viola, von Gronau, Susanne, Bollschweiler, Daniel, Schäfer, Tillman, Alpi, Arno F., Mann, Matthias, Prabu, J. Rajan, Schulman, Brenda A.

“…Cells respond to environmental changes by toggling metabolic pathways, preparing for homeostasis, and anticipating future stresses. For example, in…”
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Identification of covalent modifications regulating immune signaling complex composition and phenotype by Frauenstein, Annika, Ebner, Stefan, Hansen, Fynn M, Sinha, Ankit, Phulphagar, Kshiti, Swatek, Kirby, Hornburg, Daniel, Mann, Matthias, Meissner, Felix

“…Cells signal through rearrangements of protein communities governed by covalent modifications and reversible interactions of distinct sets of proteins. A…”
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Immunoproteasome function maintains oncogenic gene expression in KMT2A-complex driven leukemia by Tubío-Santamaría, Nuria, Jayavelu, Ashok Kumar, Schnoeder, Tina M, Eifert, Theresa, Hsu, Chen-Jen, Perner, Florian, Zhang, Qirui, Wenge, Daniela V, Hansen, Fynn M, Kirkpatrick, Joanna M, Jyotsana, Nidhi, Lane, Steven W, von Eyss, Björn, Deshpande, Aniruddha J, Kühn, Michael W M, Schwaller, Juerg, Cammann, Clemens, Seifert, Ulrike, Ebstein, Frédéric, Krüger, Elke, Hochhaus, Andreas, Heuser, Michael, Ori, Alessandro, Mann, Matthias, Armstrong, Scott A, Heidel, Florian H

“…Pharmacologic targeting of chromatin-associated protein complexes has shown significant responses in KMT2A-rearranged (KMT2A-r) acute myeloid leukemia (AML)…”
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Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV by Stukalov, Alexey, Girault, Virginie, Grass, Vincent, Karayel, Ozge, Bergant, Valter, Urban, Christian, Haas, Darya A., Huang, Yiqi, Oubraham, Lila, Wang, Anqi, Hamad, M. Sabri, Piras, Antonio, Hansen, Fynn M., Tanzer, Maria C., Paron, Igor, Zinzula, Luca, Engleitner, Thomas, Reinecke, Maria, Lavacca, Teresa M., Ehmann, Rosina, Wölfel, Roman, Jores, Jörg, Kuster, Bernhard, Protzer, Ulrike, Rad, Roland, Ziebuhr, John, Thiel, Volker, Scaturro, Pietro, Mann, Matthias, Pichlmair, Andreas

“…The emergence and global spread of SARS-CoV-2 has resulted in the urgent need for an in-depth understanding of molecular functions of viral proteins and their…”
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Rapid and In-Depth Coverage of the (Phospho-)Proteome With Deep Libraries and Optimal Window Design for dia-PASEF by Skowronek, Patricia, Thielert, Marvin, Voytik, Eugenia, Tanzer, Maria C., Hansen, Fynn M., Willems, Sander, Karayel, Özge, Brunner, Andreas-David, Meier, Florian, Mann, Matthias

“…Data-independent acquisition (DIA) methods have become increasingly attractive in mass spectrometry–based proteomics because they enable high data completeness…”
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AlphaMap: an open-source Python package for the visual annotation of proteomics data with sequence-specific knowledge by Voytik, Eugenia, Bludau, Isabell, Willems, Sander, Hansen, Fynn M, Brunner, Andreas-David, Strauss, Maximilian T, Mann, Matthias

“…Abstract Summary Integrating experimental information across proteomic datasets with the wealth of publicly available sequence annotations is a crucial part in…”
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GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme by Sherpa, Dawafuti, Chrustowicz, Jakub, Qiao, Shuai, Langlois, Christine R., Hehl, Laura A., Gottemukkala, Karthik Varma, Hansen, Fynn M., Karayel, Ozge, von Gronau, Susanne, Prabu, J. Rajan, Mann, Matthias, Alpi, Arno F., Schulman, Brenda A.

“…How are E3 ubiquitin ligases configured to match substrate quaternary structures? Here, by studying the yeast GID complex (mutation of which causes deficiency…”
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Decrypting drug actions and protein modifications by dose- and time-resolved proteomics by Zecha, Jana, Bayer, Florian P, Wiechmann, Svenja, Woortman, Julia, Berner, Nicola, Müller, Julian, Schneider, Annika, Kramer, Karl, Abril-Gil, Mar, Hopf, Thomas, Reichart, Leonie, Chen, Lin, Hansen, Fynn M, Lechner, Severin, Samaras, Patroklos, Eckert, Stephan, Lautenbacher, Ludwig, Reinecke, Maria, Hamood, Firas, Prokofeva, Polina, Vornholz, Larsen, Falcomatà, Chiara, Dorsch, Madeleine, Schröder, Ayla, Venhuizen, Anton, Wilhelm, Stephanie, Médard, Guillaume, Stoehr, Gabriele, Ruland, Jürgen, Grüner, Barbara M, Saur, Dieter, Buchner, Maike, Ruprecht, Benjamin, Hahne, Hannes, The, Matthew, Wilhelm, Mathias, Kuster, Bernhard

“…Although most cancer drugs modulate the activities of cellular pathways by changing posttranslational modifications (PTMs), little is known regarding the…”
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Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler by Liwocha, Joanna, Krist, David T., van der Heden van Noort, Gerbrand J., Hansen, Fynn M., Truong, Vinh H., Karayel, Ozge, Purser, Nicholas, Houston, Daniel, Burton, Nicole, Bostock, Mark J., Sattler, Michael, Mann, Matthias, Harrison, Joseph S., Kleiger, Gary, Ovaa, Huib, Schulman, Brenda A.

“…Virtually all aspects of cell biology are regulated by a ubiquitin code where distinct ubiquitin chain architectures guide the binding events and itineraries…”
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A New Parallel High-Pressure Packing System Enables Rapid Multiplexed Production of Capillary Columns by Müller-Reif, Johannes B., Hansen, Fynn M., Schweizer, Lisa, Treit, Peter V., Geyer, Philipp E., Mann, Matthias

“…Reversed-phase HPLC is the most commonly applied peptide-separation technique in MS-based proteomics. Particle-packed capillary columns are predominantly used…”
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A regulatory region on RIPK2 is required for XIAP binding and NOD signaling activity by Heim, Valentin J, Dagley, Laura F, Stafford, Che A, Hansen, Fynn M, Clayer, Elise, Bankovacki, Aleksandra, Webb, Andrew I, Lucet, Isabelle S, Silke, John, Nachbur, Ueli

“…Signaling via the intracellular pathogen receptors nucleotide‐binding oligomerization domain‐containing proteins NOD1 and NOD2 requires receptor interacting…”
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Mitochondrial phosphoproteomes are functionally specialized across tissues by Hansen, Fynn M, Kremer, Laura S, Karayel, Ozge, Bludau, Isabell, Larsson, Nils-Göran, Kühl, Inge, Mann, Matthias

“…Mitochondria are essential organelles whose dysfunction causes human pathologies that often manifest in a tissue-specific manner. Accordingly, mitochondrial…”
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Inhibition of mammalian mtDNA transcription acts paradoxically to reverse diet-induced hepatosteatosis and obesity by Jiang, Shan, Yuan, Taolin, Rosenberger, Florian A., Mourier, Arnaud, Dragano, Nathalia R. V., Kremer, Laura S., Rubalcava-Gracia, Diana, Hansen, Fynn M., Borg, Melissa, Mennuni, Mara, Filograna, Roberta, Alsina, David, Misic, Jelena, Koolmeister, Camilla, Papadea, Polyxeni, de Angelis, Martin Hrabe, Ren, Lipeng, Andersson, Olov, Unger, Anke, Bergbrede, Tim, Di Lucrezia, Raffaella, Wibom, Rolf, Zierath, Juleen R., Krook, Anna, Giavalisco, Patrick, Mann, Matthias, Larsson, Nils-Göran

“…The oxidative phosphorylation system 1 in mammalian mitochondria plays a key role in transducing energy from ingested nutrients 2 . Mitochondrial metabolism is…”
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A regulatory region on RIPK 2 is required for XIAP binding and NOD signaling activity by Heim, Valentin J, Dagley, Laura F, Stafford, Che A, Hansen, Fynn M, Clayer, Elise, Bankovacki, Aleksandra, Webb, Andrew I, Lucet, Isabelle S, Silke, John, Nachbur, Ueli

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Mitochondrial phosphoproteomes are functionally specialized across tissues by Hansen, Fynn M, Kremer, Laura S, Karayel, Ozge, Bludau, Isabell, Larsson, Nils-Göran, Kühl, Inge, Mann, Matthias

“…Mitochondria are essential organelles involved in critical biological processes such as energy metabolism and cell survival. Their dysfunction is linked to…”
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