Search Results - "Hansen, Diana"

Identifying Barriers to Career Progression for Women in Science: Is COVID-19 Creating New Challenges? by Hansen, Diana S.

“…This article summarizes discussions at a Gender Equity Workshop run during the Molecular Approaches to Malaria Conference in February 2020. Barriers to career…”
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Inflammatory responses associated with the induction of cerebral malaria: lessons from experimental murine models by Hansen, Diana S

“…Clearly, the analysis of intravascular inflammation predisposing to CM in humans is limited to the examination of post-mortem samples. [...]murine malaria…”
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Development of B Cell Memory in Malaria by Ly, Ann, Hansen, Diana S

“…A single exposure to many viral and bacterial pathogens typically induces life-long immunity, however, the development of the protective immunity to parasites…”
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Natural regulatory T cells in malaria: host or parasite allies? by Hansen, Diana S, Schofield, Louis

“…Plasmodium falciparum malaria causes 500 million clinical cases with approximately one million deaths each year. After many years of exposure, individuals…”
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Malaria parasite DNA-harbouring vesicles activate cytosolic immune sensors by Sisquella, Xavier, Ofir-Birin, Yifat, Pimentel, Matthew A., Cheng, Lesley, Abou Karam, Paula, Sampaio, Natália G., Penington, Jocelyn Sietsma, Connolly, Dympna, Giladi, Tal, Scicluna, Benjamin J., Sharples, Robyn A., Waltmann, Andreea, Avni, Dror, Schwartz, Eli, Schofield, Louis, Porat, Ziv, Hansen, Diana S., Papenfuss, Anthony T., Eriksson, Emily M., Gerlic, Motti, Hill, Andrew F., Bowie, Andrew G., Regev-Rudzki, Neta

“…STING is an innate immune cytosolic adaptor for DNA sensors that engage malaria parasite ( Plasmodium falciparum ) or other pathogen DNA. As P. falciparum…”
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Severe Malaria Infections Impair Germinal Center Responses by Inhibiting T Follicular Helper Cell Differentiation by Ryg-Cornejo, Victoria, Ioannidis, Lisa Julia, Ly, Ann, Chiu, Chris Yu, Tellier, Julie, Hill, Danika Lea, Preston, Simon Peter, Pellegrini, Marc, Yu, Di, Nutt, Stephen Laurence, Kallies, Axel, Hansen, Diana Silvia

“…Naturally acquired immunity to malaria develops only after years of repeated exposure to Plasmodium parasites. Despite the key role antibodies play in…”
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Immunological processes underlying the slow acquisition of humoral immunity to malaria by Ryg-Cornejo, Victoria, Ly, Ann, Hansen, Diana S

“…Malaria is one of the most serious infectious diseases with ~250 million clinical cases annually. Most cases of severe disease are caused by Plasmodium…”
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Opsonising antibodies to P. falciparum merozoites associated with immunity to clinical malaria by Hill, Danika L, Eriksson, Emily M, Li Wai Suen, Connie S N, Chiu, Chris Y, Ryg-Cornejo, Victoria, Robinson, Leanne J, Siba, Peter M, Mueller, Ivo, Hansen, Diana S, Schofield, Louis

“…Naturally acquired humoral immunity to the malarial parasite Plasmodium falciparum can protect against disease, although the precise mechanisms remain unclear…”
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GM-CSF-responsive monocyte-derived dendritic cells are pivotal in Th17 pathogenesis by Ko, Hyun-Ja, Brady, Jamie L, Ryg-Cornejo, Victoria, Hansen, Diana S, Vremec, David, Shortman, Ken, Zhan, Yifan, Lew, Andrew M

“…Although multiple dendritic cell (DC) subsets have the potential to induce Th17 differentiation in vitro, the key DC that is critical in Th17 induction and…”
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CD14 + monocytes are the main leucocytic sources of CXCL10 in response to Plasmodium falciparum by Ioannidis, Lisa J, Eriksson, Emily, Hansen, Diana S

“…The CXCR3 chemokine CXCL10 or IFN-γ inducible protein 10 (IP-10) has been identified as an important biomarker of cerebral malaria (CM) mortality in children…”
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Mechanisms of naturally acquired immunity to P. falciparum and approaches to identify merozoite antigen targets by Healer, Julie, Chiu, Chris Y, Hansen, Diana S

“…Malaria is one the most serious infectious diseases with over 200 million clinical cases annually. Most cases of the severe disease are caused by Plasmodium…”
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The role of chemokines in severe malaria: more than meets the eye by Ioannidis, Lisa J, Nie, Catherine Q, Hansen, Diana S

“…Plasmodium falciparum malaria is responsible for over 250 million clinical cases every year worldwide. Severe malaria cases might present with a range of…”
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Monocyte- and Neutrophil-Derived CXCL10 Impairs Efficient Control of Blood-Stage Malaria Infection and Promotes Severe Disease by Ioannidis, Lisa J, Nie, Catherine Q, Ly, Ann, Ryg-Cornejo, Victoria, Chiu, Chris Y, Hansen, Diana S

“…CXCL10, or IFN-γ-inducible protein 10, is a biomarker associated with increased risk for Plasmodium falciparum-mediated cerebral malaria (CM). Consistent with…”
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Transcription Factor T-bet in B Cells Modulates Germinal Center Polarization and Antibody Affinity Maturation in Response to Malaria by Ly, Ann, Liao, Yang, Pietrzak, Halina, Ioannidis, Lisa J., Sidwell, Tom, Gloury, Renee, Doerflinger, Marcel, Triglia, Tony, Qin, Raymond Z., Groom, Joanna R., Belz, Gabrielle T., Good-Jacobson, Kim L., Shi, Wei, Kallies, Axel, Hansen, Diana S.

“…Despite the key role that antibodies play in protection, the cellular processes mediating the acquisition of humoral immunity against malaria are not fully…”
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Emerging concepts in T follicular helper cell responses to malaria by Hansen, Diana S., Obeng-Adjei, Nyamekye, Ly, Ann, Ioannidis, Lisa J., Crompton, Peter D.

“…[Display omitted] •Immunity to malaria develops after many years of exposure to Plasmodium parasites.•Clinical malaria infection is characterized by the…”
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Vaccination with conserved regions of erythrocyte-binding antigens induces neutralizing antibodies against multiple strains of Plasmodium falciparum by Healer, Julie, Thompson, Jennifer K, Riglar, David T, Wilson, Danny W, Chiu, Yu-H C, Miura, Kazutoyo, Chen, Lin, Hodder, Anthony N, Long, Carole A, Hansen, Diana S, Baum, Jake, Cowman, Alan F

“…A highly effective vaccine against Plasmodium falciparum malaria should induce potent, strain transcending immunity that broadly protects against the diverse…”
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IP-10-mediated T cell homing promotes cerebral inflammation over splenic immunity to malaria infection by Nie, Catherine Q, Bernard, Nicholas J, Norman, M Ursula, Amante, Fiona H, Lundie, Rachel J, Crabb, Brendan S, Heath, William R, Engwerda, Christian R, Hickey, Michael J, Schofield, Louis, Hansen, Diana S

“…Plasmodium falciparum malaria causes 660 million clinical cases with over 2 million deaths each year. Acquired host immunity limits the clinical impact of…”
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IgM+ memory B cells induced in response to Plasmodium berghei adopt a germinal centre B cell phenotype during secondary infection by Pietrzak, Halina M., Ioannidis, Lisa J., Hansen, Diana S.

“…Emerging evidence started to delineate multiple layers of memory B cells, with distinct effector functions during recall responses. Whereas most studies…”
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Integrated systems immunology approach identifies impaired effector T cell memory responses as a feature of progression to severe dengue fever by Ioannidis, Lisa J, Studniberg, Stephanie I, Eriksson, Emily M, Suwarto, Suhendro, Denis, Dionisius, Liao, Yang, Shi, Wei, Garnham, Alexandra L, Sasmono, R Tedjo, Hansen, Diana S

“…Typical symptoms of uncomplicated dengue fever (DF) include headache, muscle pains, rash, cough, and vomiting. A proportion of cases progress to severe dengue…”
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Bezlotoxumab prevents extraintestinal organ damage induced by Clostridioides difficile infection by Mileto, Steven J., Hutton, Melanie L., Walton, Sarah L., Das, Antariksh, Ioannidis, Lisa J., Ketagoda, Don, Quinn, Kylie M., Denton, Kate M., Hansen, Diana S., Lyras, Dena

“…Clostridioides difficile is the most common cause of infectious antibiotic-associated diarrhea, with disease mediated by two major toxins TcdA and TcdB. In…”
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