Search Results - "Hansen, David V."

Microglia in Alzheimer's disease by Hansen, David V, Hanson, Jesse E, Sheng, Morgan

“…Proliferation and activation of microglia in the brain, concentrated around amyloid plaques, is a prominent feature of Alzheimer's disease (AD). Human genetics…”
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TREM2, Microglia, and Neurodegenerative Diseases by Yeh, Felix L, Hansen, David V, Sheng, Morgan

“…Alzheimer’s disease (AD) is the most common form of dementia and the 6th leading cause of death in the US. The neuropathological hallmarks of the disease are…”
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Development and Evolution of the Human Neocortex by Lui, Jan H., Hansen, David V., Kriegstein, Arnold R.

“…The size and surface area of the mammalian brain are thought to be critical determinants of intellectual ability. Recent studies show that development of the…”
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Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model by Meilandt, William J, Ngu, Hai, Gogineni, Alvin, Lalehzadeh, Guita, Lee, Seung-Hye, Srinivasan, Karpagam, Imperio, Jose, Wu, Tiffany, Weber, Martin, Kruse, Agatha J, Stark, Kimberly L, Chan, Pamela, Kwong, Mandy, Modrusan, Zora, Friedman, Brad A, Elstrott, Justin, Foreman, Oded, Easton, Amy, Sheng, Morgan, Hansen, David V

“…is an Alzheimer's disease (AD) risk gene expressed in microglia. To study the role of in a mouse model of β-amyloidosis, we compared PS2APP transgenic mice…”
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Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer’s Disease Not Evident in Mouse Models by Friedman, Brad A., Srinivasan, Karpagam, Ayalon, Gai, Meilandt, William J., Lin, Han, Huntley, Melanie A., Cao, Yi, Lee, Seung-Hye, Haddick, Patrick C.G., Ngu, Hai, Modrusan, Zora, Larson, Jessica L., Kaminker, Joshua S., van der Brug, Marcel P., Hansen, David V.

“…Microglia, the CNS-resident immune cells, play important roles in disease, but the spectrum of their possible activation states is not well understood. We…”
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Alzheimer’s Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation by Srinivasan, Karpagam, Friedman, Brad A., Etxeberria, Ainhoa, Huntley, Melanie A., van der Brug, Marcel P., Foreman, Oded, Paw, Jonathan S., Modrusan, Zora, Beach, Thomas G., Serrano, Geidy E., Hansen, David V.

“…Damage-associated microglia (DAM) profiles observed in Alzheimer’s disease (AD)-related mouse models reflect an activation state that could modulate AD risk or…”
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Neurogenic radial glia in the outer subventricular zone of human neocortex by Kriegstein, Arnold R, Hansen, David V, Lui, Jan H, Parker, Philip R. L

“…Neurons in the developing rodent cortex are generated from radial glial cells that function as neural stem cells. These epithelial cells line the cerebral…”
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Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy by Wu, Tiffany, Dejanovic, Borislav, Gandham, Vineela D., Gogineni, Alvin, Edmonds, Rose, Schauer, Stephen, Srinivasan, Karpagam, Huntley, Melanie A., Wang, Yuanyuan, Wang, Tzu-Ming, Hedehus, Maj, Barck, Kai H., Stark, Maya, Ngu, Hai, Foreman, Oded, Meilandt, William J., Elstrott, Justin, Chang, Michael C., Hansen, David V., Carano, Richard A.D., Sheng, Morgan, Hanson, Jesse E.

“…Complement pathway overactivation can lead to neuronal damage in various neurological diseases. Although Alzheimer’s disease (AD) is characterized by β-amyloid…”
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Untangling the brain’s neuroinflammatory and neurodegenerative transcriptional responses by Srinivasan, Karpagam, Friedman, Brad A., Larson, Jessica L., Lauffer, Benjamin E., Goldstein, Leonard D., Appling, Laurie L., Borneo, Jovencio, Poon, Chungkee, Ho, Terence, Cai, Fang, Steiner, Pascal, van der Brug, Marcel P., Modrusan, Zora, Kaminker, Joshua S., Hansen, David V.

“…A common approach to understanding neurodegenerative disease is comparing gene expression in diseased versus healthy tissues. We illustrate that expression…”
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Non-epithelial stem cells and cortical interneuron production in the human ganglionic eminences by Hansen, David V, Lui, Jan H, Flandin, Pierre, Yoshikawa, Kazuaki, Rubenstein, John L, Alvarez-Buylla, Arturo, Kriegstein, Arnold R

“…GABAergic cortical interneurons have important roles in the computations of neural circuits, but their developmental origin in primates is controversial. Here…”
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Progranulin deficiency causes impairment of autophagy and TDP-43 accumulation by Chang, Michael C, Srinivasan, Karpagam, Friedman, Brad A, Suto, Eric, Modrusan, Zora, Lee, Wyne P, Kaminker, Joshua S, Hansen, David V, Sheng, Morgan

“…Loss-of-function mutations in cause frontotemporal dementia (FTD) with transactive response DNA-binding protein of 43 kD (TDP-43)-positive inclusions and…”
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Mitotic spindle orientation predicts outer radial glial cell generation in human neocortex by LaMonica, Bridget E., Lui, Jan H., Hansen, David V., Kriegstein, Arnold R.

“…The human neocortex is increased in size and complexity as compared with most other species. Neocortical expansion has recently been attributed to protracted…”
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A High-Resolution Enhancer Atlas of the Developing Telencephalon by Visel, Axel, Taher, Leila, Girgis, Hani, May, Dalit, Golonzhka, Olga, Hoch, Renee V., McKinsey, Gabriel L., Pattabiraman, Kartik, Silberberg, Shanni N., Blow, Matthew J., Hansen, David V., Nord, Alex S., Akiyama, Jennifer A., Holt, Amy, Hosseini, Roya, Phouanenavong, Sengthavy, Plajzer-Frick, Ingrid, Shoukry, Malak, Afzal, Veena, Kaplan, Tommy, Kriegstein, Arnold R., Rubin, Edward M., Ovcharenko, Ivan, Pennacchio, Len A., Rubenstein, John L.R.

“…The mammalian telencephalon plays critical roles in cognition, motor function, and emotion. Though many of the genes required for its development have been…”
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Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease by Rathore, Nisha, Ramani, Sree Ranjani, Pantua, Homer, Payandeh, Jian, Bhangale, Tushar, Wuster, Arthur, Kapoor, Manav, Sun, Yonglian, Kapadia, Sharookh B, Gonzalez, Lino, Zarrin, Ali A, Goate, Alison, Hansen, David V, Behrens, Timothy W, Graham, Robert R

“…Paired Immunoglobulin-like Type 2 Receptor Alpha (PILRA) is a cell surface inhibitory receptor that recognizes specific O-glycosylated proteins and is…”
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A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death by Wetzel-Smith, Monica K, Hunkapiller, Julie, Bhangale, Tushar R, Srinivasan, Karpagam, Maloney, Janice A, Atwal, Jasvinder K, Sa, Susan M, B Yaylaoglu, Murat, Foreman, Oded, Ortmann, Ward, Rathore, Nisha, Hansen, David V, Tessier-Lavigne, Marc, Mayeux, Richard, Pericak-Vance, Margaret, Haines, Jonathan, Farrer, Lindsay A, Schellenberg, Gerard D, Goate, Alison, Behrens, Timothy W, Cruchaga, Carlos, Watts, Ryan J, Graham, Robert R

“…Mutations in UNC5C are identified in individuals with late-onset Alzheimer's disease and increase susceptibility of neurons to cell death. We have identified a…”
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Rapid affinity optimization of an anti-TREM2 clinical lead antibody by cross-lineage immune repertoire mining by Hsiao, Yi-Chun, Wallweber, Heidi Ackerly, Alberstein, Robert G., Lin, Zhonghua, Du, Changchun, Etxeberria, Ainhoa, Aung, Theint, Shang, Yonglei, Seshasayee, Dhaya, Seeger, Franziska, Watkins, Andrew M., Hansen, David V., Bohlen, Christopher J., Hsu, Peter L., Hötzel, Isidro

“…We describe a process for rapid antibody affinity optimization by repertoire mining to identify clones across B cell clonal lineages based on convergent immune…”
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Deriving Excitatory Neurons of the Neocortex from Pluripotent Stem Cells by Hansen, David V., Rubenstein, John L.R., Kriegstein, Arnold R.

“…The human cerebral cortex is an immensely complex structure that subserves critical functions that can be disrupted in developmental and degenerative…”
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Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial Engagement by Lee, Seung-Hye, Le Pichon, Claire E., Adolfsson, Oskar, Gafner, Valérie, Pihlgren, Maria, Lin, Han, Solanoy, Hilda, Brendza, Robert, Ngu, Hai, Foreman, Oded, Chan, Ruby, Ernst, James A., DiCara, Danielle, Hotzel, Isidro, Srinivasan, Karpagam, Hansen, David V., Atwal, Jasvinder, Lu, Yanmei, Bumbaca, Daniela, Pfeifer, Andrea, Watts, Ryan J., Muhs, Andreas, Scearce-Levie, Kimberly, Ayalon, Gai

“…The spread of tau pathology correlates with cognitive decline in Alzheimer’s disease. In vitro, tau antibodies can block cell-to-cell tau spreading. Although…”
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Mouse Emi2 is required to enter meiosis II by reestablishing cyclin B1 during interkinesis by Madgwick, Suzanne, Hansen, David V, Levasseur, Mark, Jackson, Peter K, Jones, Keith T

“…During interkinesis, a metaphase II (MetII) spindle is built immediately after the completion of meiosis I. Oocytes then remain MetII arrested until…”
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Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor by Miller, Julie J, Summers, Matthew K, Hansen, David V, Nachury, Maxence V, Lehman, Norman L, Loktev, Alex, Jackson, Peter K

“…The periodic destruction of mitotic cyclins is triggered by the activation of the anaphase-promoting complex/cyclosome (APC/C) in mitosis. Although the ability…”
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