Search Results - "Hansen, Bo F"

A novel high-affinity peptide antagonist to the insulin receptor by Schäffer, Lauge, Brand, Christian L., Hansen, Bo F., Ribel, Ulla, Shaw, Allan C., Slaaby, Rita, Sturis, Jeppe

“…In this publication we describe a peptide insulin receptor antagonist, S661, which is a single chain peptide of 43 amino acids. The affinity of S661 for the…”
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Molecular characterisation of long-acting insulin analogues in comparison with human insulin, IGF-1 and insulin X10 by Hansen, Bo F, Glendorf, Tine, Hegelund, Anne C, Lundby, Anders, Lützen, Anne, Slaaby, Rita, Stidsen, Carsten Enggaard

“…There is controversy with respect to molecular characteristics of insulin analogues. We report a series of experiments forming a comprehensive characterisation…”
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The α2–5′AMP-Activated Protein Kinase Is a Site 2 Glycogen Synthase Kinase in Skeletal Muscle and Is Responsive to Glucose Loading by JØRGENSEN, Sebastian B, NIELSEN, Jakob N, RICHTER, Erik A, WOJTASZEWSKI, Jørgen F. P, BIRK, Jesper B, OLSEN, Grith Skytte, VIOLLET, Benoit, ANDREELLI, Fabrizio, SCHJERLING, Peter, VAULONT, Sophie, HARDIE, D. Grahame, HANSEN, Bo F

“…The α2–5′AMP-Activated Protein Kinase Is a Site 2 Glycogen Synthase Kinase in Skeletal Muscle and Is Responsive to Glucose Loading Sebastian B. Jørgensen 1 ,…”
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Dysregulation of Glycogen Synthase COOH- and NH2-Terminal Phosphorylation by Insulin in Obesity and Type 2 Diabetes Mellitus by Højlund, Kurt, Birk, Jesper B., Klein, Ditte K., Levin, Klaus, Rose, Adam J., Hansen, Bo F., Nielsen, Jakob N., Beck-Nielsen, Henning, Wojtaszewski, Jørgen F. P.

“…Context: Insulin-stimulated glucose disposal is impaired in obesity and type 2 diabetes mellitus (T2DM) and is tightly linked to impaired skeletal muscle…”
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Isoform‐specific and exercise intensity‐dependent activation of 5′‐AMP‐activated protein kinase in human skeletal muscle by Wojtaszewski, Jørgen F. P., Nielsen, Pernille, Hansen, Bo F., Richter, Erik A., Kiens, Bente

“…1 5′‐AMP‐activated protein kinase (AMPK) has been suggested to play a key role in the regulation of metabolism in skeletal muscle. AMPK is activated in…”
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Synthesis and in Vitro Characterization of 1-(4-Aminofurazan-3-yl)-5-dialkylaminomethyl-1H-[1,2,3]triazole-4-carboxylic Acid Derivatives. A New Class of Selective GSK-3 Inhibitors by Olesen, Preben H, Sørensen, Anders R, Ursø, Birgitte, Kurtzhals, Peter, Bowler, Andrew N, Ehrbar, Ulrich, Hansen, Bo F

“…A novel class of GSK-3 inhibitors with favorable water solubility was identified in a HTS screen. SAR studies identified bioisosteric structural moieties in…”
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Systematic evaluation of the metabolic to mitogenic potency ratio for B10-substituted insulin analogues by Glendorf, Tine, Knudsen, Louise, Stidsen, Carsten E, Hansen, Bo F, Hegelund, Anne Charlotte, Sørensen, Anders R, Nishimura, Erica, Kjeldsen, Thomas

“…Insulin analogues comprising acidic amino acid substitutions at position B10 have previously been shown to display increased mitogenic potencies compared to…”
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Caffeine-Induced Impairment of Insulin Action but Not Insulin Signaling in Human Skeletal Muscle Is Reduced by Exercise by THONG, Farah S. L, DERAVE, Wim, KIENS, Bente, GRAHAM, Terry E, URSØ, Birgitte, WOJTASZEWSKI, Jørgen F. P, HANSEN, Bo F, RICHTER, Erik A

“…Caffeine-Induced Impairment of Insulin Action but Not Insulin Signaling in Human Skeletal Muscle Is Reduced by Exercise Farah S.L. Thong 1 , Wim Derave 2 ,…”
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Phosphorylation-dependent Translocation of Glycogen Synthase to a Novel Structure during Glycogen Resynthesis by Prats, Clara, Cadefau, Joan A, Cussó, Roser, Qvortrup, Klaus, Nielsen, Jakob N, Wojtaszewski, Jørgen F P, Wojtaszewki, Jørgen F P, Hardie, D Grahame, Stewart, Greg, Hansen, Bo F, Ploug, Thorkil

“…Glycogen metabolism has been the subject of extensive research, but the mechanisms by which it is regulated are still not fully understood. It is well accepted…”
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Insulin signaling in human skeletal muscle: Time course and effect of exercise by WOJTASZEWSKI, J. F. P, HANSEN, B. F, KIENS, B, RICHTER, E. A

“…Activation of early steps in the insulin signaling cascade in human skeletal muscle was investigated using a one-step euglycemic-hyperinsulinemic…”
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Increased insulin receptor binding and increased IGF-1 receptor binding are linked with increased growth of L6hIR cell xenografts in vivo by Hvid, Henning, Glendorf, Tine, Brandt, Jakob, Slaaby, Rita, Lützen, Anne, Kristensen, Kim, Hansen, Bo F.

“…Insulin analogue X10 has a higher mitogenic potency than native human insulin in vitro and supra-pharmacological doses of insulin X10 increased the incidence…”
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Glucose-sensitive insulin with attenuation of hypoglycaemia by Hoeg-Jensen, Thomas, Kruse, Thomas, Brand, Christian L., Sturis, Jeppe, Fledelius, Christian, Nielsen, Peter K., Nishimura, Erica, Madsen, Alice R., Lykke, Lennart, Halskov, Kim S., Koščová, Simona, Kotek, Vladislav, Davis, Anthony P., Tromans, Robert A., Tomsett, Michael, Peñuelas-Haro, Guillem, Leonard, Daniel J., Orchard, Michael G., Chapman, Andy, Invernizzi, Gaetano, Johansson, Eva, Granata, Daniele, Hansen, Bo F., Pedersen, Thomas A., Kildegaard, Jonas, Pedersen, Karen-Margrethe, Refsgaard, Hanne H. F., Alifrangis, Lene, Fels, Johannes J., Neutzsky-Wulff, Anita V., Sauerberg, Per, Slaaby, Rita

“…The risk of inducing hypoglycaemia (low blood glucose) constitutes the main challenge associated with insulin therapy for diabetes 1 , 2 . Insulin doses must…”
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A Novel Strategy to Prevent Advanced Atherosclerosis and Lower Blood Glucose in a Mouse Model of Metabolic Syndrome by Kanter, Jenny E, Kramer, Farah, Barnhart, Shelley, Duggan, Jeffrey M, Shimizu-Albergine, Masami, Kothari, Vishal, Chait, Alan, Bouman, Stephan D, Hamerman, Jessica A, Hansen, Bo F, Olsen, Grith S, Bornfeldt, Karin E

“…Cardiovascular disease caused by atherosclerosis is the leading cause of mortality associated with type 2 diabetes and metabolic syndrome. Insulin therapy is…”
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Activation of insulin receptors and IGF-1 receptors in COLO-205 colon cancer xenografts by insulin and insulin analogue X10 does not enhance growth under normo- or hypoglycaemic conditions by Hvid, Henning, Jørgensen, Mikkel S., Blume, Niels, Slaaby, Rita, Lützen, Anne, Hansen, Bo F.

“…Aims/hypothesis Recent studies with normal rats and mouse allograft models have reported that insulin and insulin analogues do not activate the IGF-1 receptor…”
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Preclinical exploration of combined glucagon inhibition and liver-preferential insulin for treatment of diabetes using in vitro assays and rat and mouse models by Hvid, Henning, Brand, Christian L., Hummelshøj, Tina, Jensen, Sanne, Bouman, Stephan D., Bowler, Andrew, Poulsen, Bjarne R., Tiainen, Peter, Åkertröm, Thorbjörn, Demozay, Damien, Hoeg-Jensen, Thomas, Ingvorsen, Camilla, Pedersen, Thomas Å., McGuire, Jim, Egebjerg, Thomas, Cappelen, Karen A., Eliasen, Ina P., Hansen, Bo F., Hennen, Stephanie, Stidsen, Carsten E., Olsen, Grith S., Roed, Nikolaj K.

“…Aims/hypothesis Normalisation of blood glucose in individuals with diabetes is recommended to reduce development of diabetic complications. However, risk of…”
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A framework for the in vitro evaluation of cancer-relevant molecular characteristics and mitogenic potency of insulin analogues by Baricevic, Ivona, Jones, David R, Roberts, Darren L, Lutzen, Anne, Lundby, Anders, Worm, Jesper, Hansen, Bo F, Renehan, Andrew G

“…Epidemiological and laboratory studies raise the possibility of a link between clinically prescribed insulin analogues and increased cancer risk. Accordingly,…”
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Intraintestinal and Parenteral Administration of an Insulin Analogue Leads to Comparable Activation of Signaling Downstream of the Insulin Receptor in the Small Intestine by Hvid, Henning, Kildegaard, Jonas, Kristensen, Kim, Porsgaard, Trine, Jørgensen, Mikkel S., Ballarín-González, Borja, Ahnfelt-Rønne, Jonas, Hansen, Bo F., Nishimura, Erica

“…Background: Oral delivery of insulin was recently demonstrated to have therapeutic relevance in patients with diabetes. Insulin receptors are expressed in the…”
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802-P: Beneficial Effects of a Functionally Selective Insulin on Vascular Function and Liver Triglycerides by OLSEN, GRITH S., PEDERSEN, THOMAS A., SLAABY, RITA, HANSEN, BO F., GLENDORF, TINE, DEMOZAY, DAMIEN, HVID, HENNING, NISHIMURA, ERICA, BRANDT, JAKOB, POVLEN, GRO

“…Selective insulin resistance, where insulin's ability to lower blood glucose via the Akt signaling pathway gradually decreases while retaining its…”
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Wortmannin inhibits both insulin- and contraction-stimulated glucose uptake and transport in rat skeletal muscle by Wojtaszewski, Jorgen F. P, Hansen, Bo F, Urso, Birgitte, Richter, Erik A

“…Jørgen F. P. Wojtaszewski, Bo F. Hansen, Birgitte Ursø, and Erik A. Richter Copenhagen Muscle Research Centre, August Krogh Institute, University of…”
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Surface-expressed insulin receptors as well as IGF-I receptors both contribute to the mitogenic effects of human insulin and its analogues by Lundby, Anders, Bolvig, Pernille, Hegelund, Anne Charlotte, Hansen, Bo F., Worm, Jesper, Lützen, Anne, Billestrup, Nils, Bonnesen, Christine, Oleksiewicz, Martin B.

“…There is a medical need for new insulin analogues. Yet, molecular alterations to the insulin molecule can theoretically result in analogues with carcinogenic…”
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