Search Results - "Hansen, Anders"

On instabilities of deep learning in image reconstruction and the potential costs of AI by Antun, Vegard, Renna, Francesco, Poon, Clarice, Adcock, Ben, Hansen, Anders C.

“…Deep learning, due to its unprecedented success in tasks such as image classification, has emerged as a new tool in image reconstruction with potential to…”
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The difficulty of computing stable and accurate neural networks: On the barriers of deep learning and Smale's 18th problem by Colbrook, Matthew J, Antun, Vegard, Hansen, Anders C

“…Deep learning (DL) has had unprecedented success and is now entering scientific computing with full force. However, current DL methods typically suffer from…”
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Phase-separation mechanism for C-terminal hyperphosphorylation of RNA polymerase II by Lu, Huasong, Yu, Dan, Hansen, Anders S., Ganguly, Sourav, Liu, Rongdiao, Heckert, Alec, Darzacq, Xavier, Zhou, Qiang

“…Hyperphosphorylation of the C-terminal domain (CTD) of the RPB1 subunit of human RNA polymerase (Pol) II is essential for transcriptional elongation and mRNA…”
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CTCF as a boundary factor for cohesin-mediated loop extrusion: evidence for a multi-step mechanism by Hansen, Anders S.

“…Mammalian genome structure is closely linked to function. At the scale of kilobases to megabases, CTCF and cohesin organize the genome into chromatin loops…”
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Development of an anisotropic beam finite element for composite wind turbine blades in multibody system by Kim, Taeseong, Hansen, Anders M., Branner, Kim

“…In this paper a new anisotropic beam finite element for composite wind turbine blades is developed and implemented into the aeroelastic nonlinear multibody…”
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Resolving the 3D Landscape of Transcription-Linked Mammalian Chromatin Folding by Hsieh, Tsung-Han S., Cattoglio, Claudia, Slobodyanyuk, Elena, Hansen, Anders S., Rando, Oliver J., Tjian, Robert, Darzacq, Xavier

“…Whereas folding of genomes at the large scale of epigenomic compartments and topologically associating domains (TADs) is now relatively well understood, how…”
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RNA polymerase II clustering through carboxy-terminal domain phase separation by Boehning, Marc, Dugast-Darzacq, Claire, Rankovic, Marija, Hansen, Anders S., Yu, Taekyung, Marie-Nelly, Herve, McSwiggen, David T., Kokic, Goran, Dailey, Gina M., Cramer, Patrick, Darzacq, Xavier, Zweckstetter, Markus

“…The carboxy-terminal domain (CTD) of RNA polymerase (Pol) II is an intrinsically disordered low-complexity region that is critical for pre-mRNA transcription…”
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How to Compute Spectra with Error Control by Colbrook, Matthew J, Roman, Bogdan, Hansen, Anders C

“…Computing the spectra of operators is a fundamental problem in the sciences, with wide-ranging applications in condensed-matter physics, quantum mechanics and…”
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Enhancer–promoter interactions and transcription are largely maintained upon acute loss of CTCF, cohesin, WAPL or YY1 by Hsieh, Tsung-Han S., Cattoglio, Claudia, Slobodyanyuk, Elena, Hansen, Anders S., Darzacq, Xavier, Tjian, Robert

“…It remains unclear why acute depletion of CTCF (CCCTC-binding factor) and cohesin only marginally affects expression of most genes despite substantially…”
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Molecular models of bidirectional promoter regulation by Nemsick, Sarah, Hansen, Anders S.

“…Approximately 11% of human genes are transcribed by a bidirectional promoter (BDP), defined as two genes with <1 kb between their transcription start sites…”
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CTCF and cohesin regulate chromatin loop stability with distinct dynamics by Hansen, Anders S, Pustova, Iryna, Cattoglio, Claudia, Tjian, Robert, Darzacq, Xavier

“…Folding of mammalian genomes into spatial domains is critical for gene regulation. The insulator protein CTCF and cohesin control domain location by folding…”
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Dynamics of CTCF- and cohesin-mediated chromatin looping revealed by live-cell imaging by Gabriele, Michele, Brandão, Hugo B, Grosse-Holz, Simon, Jha, Asmita, Dailey, Gina M, Cattoglio, Claudia, Hsieh, Tsung-Han S, Mirny, Leonid, Zechner, Christoph, Hansen, Anders S

“…Animal genomes are folded into loops and topologically associating domains (TADs) by CTCF and loop-extruding cohesins, but the live dynamics of loop formation…”
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Guided nuclear exploration increases CTCF target search efficiency by Hansen, Anders S., Amitai, Assaf, Cattoglio, Claudia, Tjian, Robert, Darzacq, Xavier

“…The enormous size of mammalian genomes means that for a DNA-binding protein the number of nonspecific, off-target sites vastly exceeds the number of specific,…”
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Region Capture Micro-C reveals coalescence of enhancers and promoters into nested microcompartments by Goel, Viraat Y., Huseyin, Miles K., Hansen, Anders S.

“…Although enhancers are central regulators of mammalian gene expression, the mechanisms underlying enhancer–promoter (E-P) interactions remain unclear…”
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Generalized Sampling and Infinite-Dimensional Compressed Sensing by Adcock, Ben, Hansen, Anders C.

“…We introduce and analyze a framework and corresponding method for compressed sensing in infinite dimensions. This extends the existing theory from…”
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Distinct Classes of Chromatin Loops Revealed by Deletion of an RNA-Binding Region in CTCF by Hansen, Anders S., Hsieh, Tsung-Han S., Cattoglio, Claudia, Pustova, Iryna, Saldaña-Meyer, Ricardo, Reinberg, Danny, Darzacq, Xavier, Tjian, Robert

“…Mammalian genomes are folded into topologically associating domains (TADs), consisting of chromatin loops anchored by CTCF and cohesin. Some loops are…”
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Recent evidence that TADs and chromatin loops are dynamic structures by Hansen, Anders S., Cattoglio, Claudia, Darzacq, Xavier, Tjian, Robert

“…Mammalian genomes are folded into spatial domains, which regulate gene expression by modulating enhancer-promoter contacts. Here, we review recent studies on…”
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Enhancer selectivity in space and time: from enhancer–promoter interactions to promoter activation by Yang, Jin H., Hansen, Anders S.

“…The primary regulators of metazoan gene expression are enhancers, originally functionally defined as DNA sequences that can activate transcription at promoters…”
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CTCF sites display cell cycle-dependent dynamics in factor binding and nucleosome positioning by Oomen, Marlies E, Hansen, Anders S, Liu, Yu, Darzacq, Xavier, Dekker, Job

“…CCCTC-binding factor (CTCF) plays a key role in the formation of topologically associating domains (TADs) and loops in interphase. During mitosis TADs are…”
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Tracking and interpreting long-range chromatin interactions with super-resolution live-cell imaging by Brandão, Hugo B., Gabriele, Michele, Hansen, Anders S.

“…Mammalian genomes are organized and regulated through long-range chromatin interactions. Structural loops formed by CCCTC-binding factor (CTCF) and cohesin…”
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