Search Results - "Hansbro, Philip M."

SARS-CoV-2 induces transcriptional signatures in human lung epithelial cells that promote lung fibrosis by Xu, Jincheng, Xu, Xiaoyue, Jiang, Lina, Dua, Kamal, Hansbro, Philip M, Liu, Gang

“…Severe acute respiratory syndrome (SARS)-CoV-2-induced coronavirus disease-2019 (COVID-19) is a pandemic disease that affects > 2.8 million people worldwide,…”
Get full text

Emerging pathogenic links between microbiota and the gut–lung axis by Budden, Kurtis F., Gellatly, Shaan L., Wood, David L. A., Cooper, Matthew A., Morrison, Mark, Hugenholtz, Philip, Hansbro, Philip M.

“…Key Points The gastrointestinal tract (GIT) and respiratory tract, although separate organs, are part of a shared mucosal immune system termed the gut–lung…”
Get full text

Disease-associated gut microbiome and metabolome changes in patients with chronic obstructive pulmonary disease by Bowerman, Kate L., Rehman, Saima Firdous, Vaughan, Annalicia, Lachner, Nancy, Budden, Kurtis F., Kim, Richard Y., Wood, David L. A., Gellatly, Shaan L., Shukla, Shakti D., Wood, Lisa G., Yang, Ian A., Wark, Peter A., Hugenholtz, Philip, Hansbro, Philip M.

“…Chronic obstructive pulmonary disease (COPD) is the third commonest cause of death globally, and manifests as a progressive inflammatory lung disease with no…”
Get full text

Biomedical applications of metallic nanoparticles in cancer: Current status and future perspectives by Khursheed, Rubiya, Dua, Kamal, Vishwas, Sukriti, Gulati, Monica, Jha, Niraj Kumar, Aldhafeeri, Ghalib Mohammed, Alanazi, Fayez Ghadeer, Goh, Bey Hing, Gupta, Gaurav, Paudel, Keshav Raj, Hansbro, Philip M., Chellappan, Dinesh Kumar, Singh, Sachin Kumar

“…The current advancements in nanotechnology are as an outcome of the development of engineered nanoparticles. Various metallic nanoparticles have been…”
Get full text

Functional effects of the microbiota in chronic respiratory disease by Budden, Kurtis F, Shukla, Shakti D, Rehman, Saima Firdous, Bowerman, Kate L, Keely, Simon, Hugenholtz, Philip, Armstrong-James, Darius P H, Adcock, Ian M, Chotirmall, Sanjay H, Chung, Kian Fan, Hansbro, Philip M

“…The composition of the lung microbiome is increasingly well characterised, with changes in microbial diversity or abundance observed in association with…”
Get full text

Abnormal M1/M2 macrophage phenotype profiles in the small airway wall and lumen in smokers and chronic obstructive pulmonary disease (COPD) by Eapen, Mathew Suji, Hansbro, Philip M., McAlinden, Kielan, Kim, Richard Y., Ward, Chris, Hackett, Tillie-Louise, Walters, Eugene H., Sohal, Sukhwinder Singh

“…We explore potential dysregulation of macrophage phenotypes in COPD pathogenesis through integrated study of human small airway tissue, bronchoalveolar lavage…”
Get full text

Animal models of chronic obstructive pulmonary disease by Fricker, Michael, Deane, Andrew, Hansbro, Philip M

“…Chronic obstructive pulmonary disease (COPD) is a leading global cause of mortality and chronic morbidity. Inhalation of cigarette smoke is the principal risk…”
Get more information

Stinging Nettle (Urtica dioica L.): Nutritional Composition, Bioactive Compounds, and Food Functional Properties by Devkota, Hari Prasad, Paudel, Keshav Raj, Khanal, Shristi, Baral, Ananda, Panth, Nisha, Adhikari-Devkota, Anjana, Jha, Niraj Kumar, Das, Niranjan, Singh, Sachin Kumar, Chellappan, Dinesh Kumar, Dua, Kamal, Hansbro, Philip M

“…Stinging nettle (Urtica dioica L., Urticaceae) is commonly found in Asia, Africa, and Europe and has a long history of being used as food and traditional…”
Get full text

Microbiome effects on immunity, health and disease in the lung by Shukla, Shakti D, Budden, Kurtis F, Neal, Rachael, Hansbro, Philip M

“…Chronic respiratory diseases, including asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF), are among the leading causes of…”
Get full text

Saturated fatty acids, obesity, and the nucleotide oligomerization domain–like receptor protein 3 (NLRP3) inflammasome in asthmatic patients by Wood, Lisa G., Li, Qian, Scott, Hayley A., Rutting, Sandra, Berthon, Bronwyn S., Gibson, Peter G., Hansbro, Philip M., Williams, Evan, Horvat, Jay, Simpson, Jodie L., Young, Paul, Oliver, Brian G., Baines, Katherine J.

“…Both obesity and high dietary fat intake activate the nucleotide oligomerization domain–like receptor protein 3 (NLRP3) inflammasome. We aimed to examine NLRP3…”
Get full text

Airway epithelial regulation of pulmonary immune homeostasis and inflammation by Hallstrand, Teal S, Hackett, Tillie L, Altemeier, William A, Matute-Bello, Gustavo, Hansbro, Philip M, Knight, Darryl A

“…Abstract Recent genetic, structural and functional studies have identified the airway and lung epithelium as a key orchestrator of the immune response…”
Get full text

Elastin is a key factor of tumor development in colorectal cancer by Li, Jinzhi, Xu, Xiaoyue, Jiang, Yanyan, Hansbro, Nicole G, Hansbro, Philip M, Xu, Jincheng, Liu, Gang

“…Colorectal cancer (CRC) is the most common cancer and a leading cause of death worldwide. Extracellular matrix (ECM) proteins regulate tumor growth and…”
Get full text

The role of acute and chronic respiratory colonization and infections in the pathogenesis of COPD by Leung, Janice M., Tiew, Pei Yee, Mac Aogáin, Micheál, Budden, Kurtis F., Yong, Valerie Fei Lee, Thomas, Sangeeta S., Pethe, Kevin, Hansbro, Philip M., Chotirmall, Sanjay H.

“…ABSTRACT COPD is a major global concern, increasingly so in the context of ageing populations. The role of infections in disease pathogenesis and progression…”
Get full text

Modeling TH2 responses and airway inflammation to understand fundamental mechanisms regulating the pathogenesis of asthma by Foster, Paul S., Maltby, Steven, Rosenberg, Helene F., Tay, Hock L., Hogan, Simon P., Collison, Adam M., Yang, Ming, Kaiko, Gerard E., Hansbro, Philip M., Kumar, Rakesh K., Mattes, Joerg

“…Summary In this review, we highlight experiments conducted in our laboratories that have elucidated functional roles for CD4+ T‐helper type‐2 lymphocytes (TH2…”
Get full text

Genomic characterization of the uncultured Bacteroidales family S24-7 inhabiting the guts of homeothermic animals by Ormerod, Kate L, Wood, David L A, Lachner, Nancy, Gellatly, Shaan L, Daly, Joshua N, Parsons, Jeremy D, Dal'Molin, Cristiana G O, Palfreyman, Robin W, Nielsen, Lars K, Cooper, Matthew A, Morrison, Mark, Hansbro, Philip M, Hugenholtz, Philip

“…Our view of host-associated microbiota remains incomplete due to the presence of as yet uncultured constituents. The Bacteroidales family S24-7 is a prominent…”
Get full text

Targeting Cancer using Curcumin Encapsulated Vesicular Drug Delivery Systems by Hardwick, Joel, Taylor, Jack, Mehta, Meenu, Satija, Saurabh, Paudel, Keshav R, Hansbro, Philip M, Chellappan, Dinesh K, Bebawy, Mary, Dua, Kamal

“…Curcumin is a major curcuminoid present in turmeric. The compound is attributed to various therapeutic properties, which include anti-oxidant,…”
Get more information

Mechanisms and treatments for severe, steroid‐resistant allergic airway disease and asthma by Hansbro, Philip M., Kim, Richard Y., Starkey, Malcolm R., Donovan, Chantal, Dua, Kamal, Mayall, Jemma R., Liu, Gang, Hansbro, Nicole G., Simpson, Jodie L., Wood, Lisa G., Hirota, Jeremy A., Knight, Darryl A., Foster, Paul S., Horvat, Jay C.

“…Summary Severe, steroid‐resistant asthma is clinically and economically important since affected individuals do not respond to mainstay corticosteroid…”
Get full text

Recent Developments in Alpha-Glucosidase Inhibitors for Management of Type-2 Diabetes: An Update by Usman, Bashir, Sharma, Neha, Satija, Saurabh, Mehta, Meenu, Vyas, Manish, Khatik, Gopal L, Khurana, Navneet, Hansbro, Philip M, Williams, Kylie, Dua, Kamal

“…The incidence of diabetes has increased globally in recent years and figures of diabetic patients were estimated to rise up to 642 million by 2040. The…”
Get more information

Critical role for iron accumulation in the pathogenesis of fibrotic lung disease by Ali, Md Khadem, Kim, Richard Y, Brown, Alexandra C, Donovan, Chantal, Vanka, Kanth S, Mayall, Jemma R, Liu, Gang, Pillar, Amber L, Jones‐Freeman, Bernadette, Xenaki, Dikaia, Borghuis, Theo, Karim, Rafia, Pinkerton, James W, Aryal, Ritambhara, Heidari, Moones, Martin, Kristy L, Burgess, Janette K, Oliver, Brian G, Trinder, Debbie, Johnstone, Daniel M, Milward, Elizabeth A, Hansbro, Philip M, Horvat, Jay C

“…Increased iron levels and dysregulated iron homeostasis, or both, occur in several lung diseases. Here, the effects of iron accumulation on the pathogenesis of…”
Get full text

ZAP‐70 Genotype Disrupts the Relationship Between Microbiota and Host, Leading to Spondyloarthritis and Ileitis in SKG Mice by Rehaume, Linda M., Mondot, Stanislas, Aguirre de Cárcer, Daniel, Velasco, Jared, Benham, Helen, Hasnain, Sumaira Z., Bowman, Jaclyn, Ruutu, Merja, Hansbro, Philip M., McGuckin, Michael A., Morrison, Mark, Thomas, Ranjeny

“…Objective The spondyloarthritides share genetic susceptibility, interleukin‐23 (IL‐23) dependence, and the involvement of microbiota. The aim of the current…”
Get full text