Search Results - "Hanrahan, Jane R."

GABA allosteric modulators: An overview of recent developments in non-benzodiazepine modulators by Solomon, Viswas Raja, Tallapragada, Vikram J., Chebib, Mary, Johnston, G.A.R., Hanrahan, Jane R.

“…γ-Aminobutyric acid (GABA) is the major inhibitory transmitter controlling synaptic transmission and neuronal excitability. It is present in a high percentage…”
Get full text

Traditional Uses, Phytochemistry and Pharmacological Activities of Annonacae by Al Kazman, Bassam S M, Harnett, Joanna E, Hanrahan, Jane R

“…In 1789, the Annonaceae family was catalogued by de Jussieu. It encompasses tropical and subtropical plants which are widespread in distribution across various…”
Get full text

Kynurenine Aminotransferases and the Prospects of Inhibitors for the Treatment of Schizophrenia by Jayawickrama, Gayan S, Sadig, Richard R, Sun, Guanchen, Nematollahi, Alireza, Nadvi, Naveed A, Hanrahan, Jane R, Gorrell, Mark D, Church, W Bret

“…Schizophrenia is a complex neuropsychiatric disorder with limited treatment options and highly debilitating symptoms, leading to poor personal, social, and…”
Get more information

Ethnobotany, phytochemistry and pharmacology of the genus Caragana used in traditional Chinese medicine by Meng, Qiuxia, Niu, Yu, Niu, Xiwu, Roubin, Rebecca H., Hanrahan, Jane R.

“…The genus Caragana is a member of the family Fabaceae, subfamily Faboideae and is native to arid and semi-arid areas of the temperate zones of Asia and Eastern…”
Get full text

Ceramide Regulates Anti-Tumor Mechanisms of Erianin in Androgen-Sensitive and Castration-Resistant Prostate Cancers by Trapika, I Gusti Md Gde Surya C, Liu, Xin Tracy, Chung, Long Hoa, Lai, Felcia, Xie, Chanlu, Zhao, Yang, Cui, Shaohui, Chen, Jinbiao, Tran, Collin, Wang, Qian, Zhang, Shubiao, Don, Anthony S, Li, George Qian, Hanrahan, Jane R, Qi, Yanfei

“…Prostate cancer is the second most prevalent malignancy worldwide. In the early stages, the development of prostate cancer is dependent on androgens. Over time…”
Get full text

The Phytochemical Constituents and Pharmacological Activities of Annona atemoya: A Systematic Review by Kazman, Bassam S. M. Al, Harnett, Joanna E., Hanrahan, Jane R.

“…Annona atemoya also known as the custard apple is a hybrid between two Annonaceae species: Cherimoya (Annona cherimola) and the sugar apple (Annona squamosa)…”
Get full text

The Direct Actions of GABA, 2'-Methoxy-6-Methylflavone and General Anaesthetics at β3γ2L GABAA Receptors: Evidence for Receptors with Different Subunit Stoichiometries by Chua, Han Chow, Absalom, Nathan L, Hanrahan, Jane R, Viswas, Raja, Chebib, Mary

“…2'-Methoxy-6-methylflavone (2'MeO6MF) is an anxiolytic flavonoid which has been shown to display GABAA receptor (GABAAR) β2/3-subunit selectivity, a…”
Get full text

Pharmacological Effect of GABA Analogues on GABA-ϱ2 Receptors and Their Subtype Selectivity by Naffaa, Moawiah M., Hibbs, David E., Chebib, Mary, Hanrahan, Jane R.

“…GABAϱ receptors are distinctive GABAergic receptors from other ionotropic GABAA and metabotropic GABAB receptors in their pharmacological, biochemical, and…”
Get full text

Study of the Activity and Possible Mechanism of Action of a Reversible Inhibitor of Recombinant Human KAT-2: A Promising Lead in Neurodegenerative and Cognitive Disorders by Nematollahi, Alireza, Sun, Guanchen, Jayawickrama, Gayan S, Hanrahan, Jane R, Church, W Bret

“…Abnormal levels of kynurenic acid (KYNA) in the human brain are believed to be connected to several central nervous system (CNS) diseases, therefore compounds…”
Get full text

Structure of the PLP-Form of the Human Kynurenine Aminotransferase II in a Novel Spacegroup at 1.83 Å Resolution by Nematollahi, Alireza, Sun, Guanchen, Harrop, Stephen J, Hanrahan, Jane R, Church, W Bret

“…Kynurenine aminotransferase II (KAT-II) is a 47 kDa pyridoxal phosphate (PLP)-dependent enzyme, active as a homodimer, which catalyses the transamination of…”
Get full text

Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin‐Q by Yow, Tin T, Pera, Elena, Absalom, Nathan, Heblinski, Marika, Johnston, Graham AR, Hanrahan, Jane R, Chebib, Mary

“…BACKGROUND G protein‐coupled inwardly rectifying potassium (KIR3) channels are important proteins that regulate numerous physiological processes including…”
Get full text

Investigating the Role of Loop C Hydrophilic Residue 'T244' in the Binding Site of ρ1 GABAC Receptors via Site Mutation and Partial Agonism by Naffaa, Moawiah M, Absalom, Nathan, Solomon, V Raja, Chebib, Mary, Hibbs, David E, Hanrahan, Jane R

“…The loop C hydrophilic residue, threonine 244 lines the orthosteric binding site of ρ1 GABAC receptors was studied by point mutation into serine, alanine and…”
Get full text

Novel, potent, and selective GABAC antagonists inhibit myopia development and facilitate learning and memory by Chebib, Mary, Hinton, Tina, Schmid, Katrina L, Brinkworth, Darren, Qian, Haohua, Matos, Susana, Kim, Hye-Lim, Abdel-Halim, Heba, Kumar, Rohan J, Johnston, Graham A R, Hanrahan, Jane R

“…This study reports pharmacological and physiological effects of cis- and trans-(3-aminocyclopentanyl)butylphosphinic acid (cis- and trans-3-ACPBPA). These…”
Get more information

Targeting GABAC Receptors Improves Post-Stroke Motor Recovery by van Nieuwenhuijzen, Petra S., Parker, Kim, Liao, Vivian, Houlton, Josh, Kim, Hye-Lim, Johnston, Graham A. R., Hanrahan, Jane R., Chebib, Mary, Clarkson, Andrew N.

“…Ischemic stroke remains a leading cause of disability worldwide, with limited treatment options available. This study investigates GABAC receptors as novel…”
Get full text

Crystal structure and mechanistic analysis of a novel human kynurenine aminotransferase-2 reversible inhibitor by Nematollahi, Alireza, Sun, Guanchen, Jayawickrama, Gayan S., Hanrahan, Jane R., Church, W. Bret

“…NS-1502 is a reversible inhibitor of human kynurenine aminotransferase-2 (hKAT-2), which is implicated in a number of central nervous system disorders…”
Get full text

Neurochemicals for the Investigation of GABAC Receptors by Johnston, Graham A. R., Chebib, Mary, Hanrahan, Jane R., Mewett, Kenneth N.

“…GABA C receptors are being investigated for their role in many aspects of nervous system function including memory, myopia, pain and sleep. There is evidence…”
Get full text

Flavonoid modulation of GABA(A) receptors by Hanrahan, Jane R, Chebib, Mary, Johnston, Graham A R

“…There has been a resurgence of interest in synthetic and plant-derived flavonoids as modulators of γ-amino butyric acid-A (GABA(A) ) receptor function…”
Get full text

Student‐led interprofessional influenza vaccination clinic in a time of coronavirus by Hanrahan, Jane R., Carroll, Peter R.

Get full text

GABAA receptors containing ρ1 subunits contribute to in vivo effects of ethanol in mice by Blednov, Yuri A, Benavidez, Jillian M, Black, Mendy, Leiter, Courtney R, Osterndorff-Kahanek, Elizabeth, Johnson, David, Borghese, Cecilia M, Hanrahan, Jane R, Johnston, Graham A R, Chebib, Mary, Harris, R Adron

“…GABAA receptors consisting of ρ1, ρ2, or ρ3 subunits in homo- or hetero-pentamers have been studied mainly in retina but are detected in many brain regions…”
Get full text

Molecular docking and antiamnesic effects of nepitrin isolated from Rosmarinus officinalis on scopolamine-induced memory impairment in mice by Karim, Nasiara, Khan, Imran, Abdelhalim, Abeer, Abdel-Halim, Heba, Hanrahan, Jane R.

“…[Display omitted] Rosmarinus officinalis has long been known as the herb of remembrance. The present study was undertaken to investigate the anti-amnesic…”
Get full text