Search Results - "Hannigan, Molly M"
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Ptbp2 Controls an Alternative Splicing Network Required for Cell Communication during Spermatogenesis
Published in Cell reports (Cambridge) (20-06-2017)“…Alternative splicing has essential roles in development. Remarkably, spermatogenic cells express more alternatively spliced RNAs compared to most whole…”
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Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane
Published in Molecular & cellular proteomics (01-11-2020)“…Hannigan et al. characterize the protein interactomes of four candidate ER ribosome-binding proteins, providing evidence that ER-bound ribosomes reside in…”
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DAZL Regulates Germ Cell Survival through a Network of PolyA-Proximal mRNA Interactions
Published in Cell reports (Cambridge) (30-10-2018)“…The RNA binding protein DAZL is essential for gametogenesis, but its direct in vivo functions, RNA targets, and the molecular basis for germ cell loss…”
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DAZL Regulates Germ Cell Survival through a Network of PolyA-Proximal mRNA Interactions
Published in Cell reports (Cambridge) (01-10-2018)Get full text
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The transcriptional repressor BCL11A promotes breast cancer metastasis
Published in The Journal of biological chemistry (14-08-2020)“…The phenotypes of each breast cancer subtype are defined by their transcriptomes. However, the transcription factors that regulate differential patterns of…”
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Examining SRP pathway function in mRNA localization to the endoplasmic reticulum
Published in RNA (Cambridge) (01-11-2023)“…Signal recognition particle (SRP) pathway function in protein translocation across the endoplasmic reticulum (ER) is well established; its role in RNA…”
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RNA Binding Protein Ptbp2 Is Essential for Male Germ Cell Development
Published in Molecular and cellular biology (01-12-2015)“…RNA binding proteins (RBPs) are increasingly recognized as essential factors in tissue development and homeostasis. The polypyrimidine tract binding (PTB)…”
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Abstract 32: BCL11A is necessary for the expression of extracellular matrix genes and metastatic progression of triple-negative breast cancer
Published in Cancer research (Chicago, Ill.) (01-07-2018)“…Abstract Cancer stem cells (CSC) contribute to the high incidence of metastatic recurrence in triple-negative breast cancer (TNBC) and elucidating the…”
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The Functions and Regulation of mRNA Processing During Male Germ Cell Development
Published 01-01-2019“…Alternative RNA processing is a critical factor in increasing transcriptome complexity during cell differentiation and tissue development. Remarkably,…”
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Dissertation