Extracorporeal Hyperoxygenation Therapy (EHT) for Carbon Monoxide Poisoning: In-Vitro Proof of Principle

Extracorporeal Hyperoxygenation Therapy (EHT) for Carbon Monoxide Poisoning: In-Vitro Proof of Principle

Carbon monoxide (CO) poisoning is the leading cause of poisoning-related deaths globally. The currently available therapy options are normobaric oxygen (NBO) and hyperbaric oxygen (HBO). While NBO lacks in efficacy, HBO is not available in all areas and countries. We present a novel method, extracor...

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Bibliographic Details
Published in:Membranes (Basel) Vol. 12; no. 1; p. 56
Main Authors: Steuer, Niklas B, Schlanstein, Peter C, Hannig, Anke, Sibirtsev, Stephan, Jupke, Andreas, Schmitz-Rode, Thomas, Kopp, Rüdger, Steinseifer, Ulrich, Wagner, Georg, Arens, Jutta
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 31-12-2021
MDPI
Subjects:
Blood
Carbon monoxide
Carbon monoxide poisoning
Carboxyhemoglobin
Chronic obstructive pulmonary disease
Experiments
Extracorporeal membrane oxygenation
extracorporeal therapy
Hemoglobin
Hollow fiber membranes
hollow fibre membrane oxygenator
Hyperbaric oxygen
hyperoxygenation
In vitro methods and tests
Lungs
Oxygen
oxygenator
Partial pressure
Poisoning
Respiration
Surgical apparatus & instruments
Therapy
Velocity
Netherlands
United States > US
Europe
Germany
extracorporeal therapy
poisoning
hyperoxygenation
bubble oxygenator
oxygenator
carbon monoxide
hollow fibre membrane oxygenator
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Summary:Carbon monoxide (CO) poisoning is the leading cause of poisoning-related deaths globally. The currently available therapy options are normobaric oxygen (NBO) and hyperbaric oxygen (HBO). While NBO lacks in efficacy, HBO is not available in all areas and countries. We present a novel method, extracorporeal hyperoxygenation therapy (EHT), for the treatment of CO poisoning that eliminates the CO by treating blood extracorporeally at elevated oxygen partial pressure. In this study, we proof the principle of the method in vitro using procine blood: Firstly, we investigated the difference in the CO elimination of a hollow fibre membrane oxygenator and a specifically designed batch oxygenator based on the bubble oxygenator principle at elevated pressures (1, 3 bar). Secondly, the batch oxygenator was redesigned and tested for a broader range of pressures (1, 3, 5, 7 bar) and temperatures (23, 30, 37 °C). So far, the shortest measured carboxyhemoglobin half-life in the blood was 21.32 min. In conclusion, EHT has the potential to provide an easily available and effective method for the treatment of CO poisoning.
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ISSN:2077-0375
2077-0375
DOI:10.3390/membranes12010056