Search Results - "Hannezo, Edouard"
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Theory of mechanochemical patterning and optimal migration in cell monolayers
Published in Nature physics (01-02-2021)“…Collective cell migration offers a rich field of study for non-equilibrium physics and cellular biology, revealing phenomena such as glassy dynamics, pattern…”
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Morphogen gradient orchestrates pattern-preserving tissue morphogenesis via motility-driven unjamming
Published in Nature physics (01-12-2022)“…Embryo development requires biochemical signalling to generate patterns of cell fates and active mechanical forces to drive tissue shape changes. However, how…”
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3
Cell fate coordinates mechano-osmotic forces in intestinal crypt formation
Published in Nature cell biology (01-07-2021)“…Intestinal organoids derived from single cells undergo complex crypt–villus patterning and morphogenesis. However, the nature and coordination of the…”
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Physics of active jamming during collective cellular motion in a monolayer
Published in Proceedings of the National Academy of Sciences - PNAS (15-12-2015)“…Although collective cell motion plays an important role, for example during wound healing, embryogenesis, or cancer progression, the fundamental rules…”
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Theory of epithelial sheet morphology in three dimensions
Published in Proceedings of the National Academy of Sciences - PNAS (07-01-2014)“…Morphogenesis during embryo development requires the coordination of mechanical forces to generate the macroscopic shapes of organs. We propose a minimal…”
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Rigidity percolation uncovers a structural basis for embryonic tissue phase transitions
Published in Cell (01-04-2021)“…Embryo morphogenesis is impacted by dynamic changes in tissue material properties, which have been proposed to occur via processes akin to phase transitions…”
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Cell monolayers sense curvature by exploiting active mechanics and nuclear mechanoadaptation
Published in Nature physics (01-12-2021)“…The early development of many organisms involves the folding of cell monolayers, but this behaviour is difficult to reproduce in vitro; therefore, both…”
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Alignment of cellular motility forces with tissue flow as a mechanism for efficient wound healing
Published in Proceedings of the National Academy of Sciences - PNAS (12-02-2013)“…Recent experiments have shown that spreading epithelial sheets exhibit a long-range coordination of motility forces that leads to a buildup of tension in the…”
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Active cell migration is critical for steady-state epithelial turnover in the gut
Published in Science (American Association for the Advancement of Science) (16-08-2019)“…Steady-state turnover is a hallmark of epithelial tissues throughout adult life. Intestinal epithelial turnover is marked by continuous cell migration, which…”
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A Unifying Theory of Branching Morphogenesis
Published in Cell (21-09-2017)“…The morphogenesis of branched organs remains a subject of abiding interest. Although much is known about the underlying signaling pathways, it remains unclear…”
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Glass-like dynamics of collective cell migration
Published in Proceedings of the National Academy of Sciences - PNAS (22-03-2011)“…Collective cell migration in tissues occurs throughout embryonic development, during wound healing, and in cancerous tumor invasion, yet most detailed…”
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Emergence of an Apical Epithelial Cell Surface In Vivo
Published in Developmental cell (11-01-2016)“…Epithelial sheets are crucial components of all metazoan animals, enclosing organs and protecting the animal from its environment. Epithelial homeostasis poses…”
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Tracing the origin of adult intestinal stem cells
Published in Nature (London) (01-06-2019)“…Adult intestinal stem cells are located at the bottom of crypts of Lieberkühn, where they express markers such as LGR5 1 , 2 and fuel the constant…”
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Balance between Apical Membrane Growth and Luminal Matrix Resistance Determines Epithelial Tubule Shape
Published in Cell reports (Cambridge) (01-05-2014)“…The morphological stability of biological tubes is crucial for the efficient circulation of fluids and gases. Failure of this stability causes irregularly…”
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Theory of branching morphogenesis by local interactions and global guidance
Published in Nature communications (24-11-2021)“…Branching morphogenesis governs the formation of many organs such as lung, kidney, and the neurovascular system. Many studies have explored system-specific…”
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Transmission of cytokinesis forces via E-cadherin dilution and actomyosin flows
Published in Nature (London) (04-05-2017)“…Under physiological forces, resulting from cytokinesis, the mechanosensitivity of adherens junction arises from a local decrease in E-cadherin concentration…”
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Bulk Actin Dynamics Drive Phase Segregation in Zebrafish Oocytes
Published in Cell (30-05-2019)“…Segregation of maternal determinants within the oocyte constitutes the first step in embryo patterning. In zebrafish oocytes, extensive ooplasmic streaming…”
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18
Cortical instability drives periodic supracellular actin pattern formation in epithelial tubes
Published in Proceedings of the National Academy of Sciences - PNAS (14-07-2015)“…An essential question of morphogenesis is how patterns arise without preexisting positional information, as inspired by Turing. In the past few years,…”
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Identity and dynamics of mammary stem cells during branching morphogenesis
Published in Nature (London) (16-02-2017)“…During puberty, the mouse mammary gland develops into a highly branched epithelial network. Owing to the absence of exclusive stem cell markers, the location,…”
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Self-organized and directed branching results in optimal coverage in developing dermal lymphatic networks
Published in Nature communications (21-09-2023)“…Branching morphogenesis is a ubiquitous process that gives rise to high exchange surfaces in the vasculature and epithelial organs. Lymphatic capillaries form…”
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