Search Results - "Hannemann, Nicole"
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The Transcription Factor FRA-1/AP-1 Controls Lipocalin-2 Expression and Inflammation in Sepsis Model
Published in Frontiers in immunology (12-10-2021)“…Sepsis is a life-threatening condition characterized by excessive inflammation in its early phase. This is followed by an aberrant resolution phase associated…”
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Inhibition of Osteoarthritis by Adipose‐Derived Stromal Cells Overexpressing Fra‐1 in Mice
Published in Arthritis & rheumatology (Hoboken, N.J.) (01-01-2016)“…Objective To determine whether overexpression of the activator protein 1 (AP‐1) transcription factor Fra‐1 in adipose‐derived stromal cells (ADSCs) is an…”
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Utilizing Pediatric Chief Residents in Patient Flow Management: A Systems-Based Practice
Published in Academic pediatrics (01-08-2016)Get full text
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4
Synovial macrophages: from ordinary eaters to extraordinary multitaskers
Published in Trends in immunology (01-05-2021)“…Like other tissues, joints contain resident macrophages, and their diversity is only beginning to be characterized. Based on the highlights of recent studies,…”
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New insights into macrophage heterogeneity in rheumatoid arthritis
Published in Joint, bone, spine : revue du rhumatisme (01-01-2021)“…•Recent single cell RNA sequencing studies of human and mouse joint tissue revealed high heterogeneity of lining and interstitial macrophages in health and…”
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Microbiota from Obese Mice Regulate Hematopoietic Stem Cell Differentiation by Altering the Bone Niche
Published in Cell metabolism (03-11-2015)“…The effect of metabolic stress on the bone marrow microenvironment is poorly defined. We show that high-fat diet (HFD) decreased long-term Lin−Sca-1+c-Kit+…”
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Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
Published in Journal of visualized experiments (03-06-2016)“…Considering that adipose tissue (AT) is an endocrine organ, it can influence whole body metabolism. Excessive energy storage leads to the dysregulation of…”
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Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
Published in Journal of visualized experiments (03-06-2016)Get full text
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Transcription factor Fra-1 targets arginase-1 to enhance macrophage-mediated inflammation in arthritis
Published in The Journal of clinical investigation (01-07-2019)“…The polarization of macrophages is regulated by transcription factors such as nuclear factor kappa B (NF-κB) and activator protein 1 (AP-1). In this…”
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The AP-1 Transcription Factor c-Jun Promotes Arthritis by Regulating Cyclooxygenase-2 and Arginase-1 Expression in Macrophages
Published in The Journal of immunology (1950) (01-05-2017)“…Activation of proinflammatory macrophages is associated with the inflammatory state of rheumatoid arthritis. Their polarization and activation are controlled…”
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Anti-inflammatory, but not osteoprotective, effect of the TRAF6/CD40 inhibitor 6877002 in rodent models of local and systemic osteolysis
Published in Biochemical pharmacology (01-01-2022)“…[Display omitted] NFκB plays a key role in inflammation and skeletal disorders. Previously, we reported that pharmacological inhibition of NFκB at the level of…”
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Fra-2 Expression in Osteoblasts Regulates Systemic Inflammation and Lung Injury through Osteopontin
Published in Molecular and cellular biology (01-11-2018)“…Inflammatory responses require mobilization of innate immune cells from the bone marrow. The functionality of this process depends on the state of the bone…”
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Changes in mechanical loading affect arthritis-induced bone loss in mice
Published in Bone (New York, N.Y.) (01-02-2020)“…Arthritis induces bone loss by inflammation-mediated disturbance of bone homeostasis. On the other hand, pain and impaired locomotion are highly prevalent in…”
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Fever : Pathogenesis and Treatment
Published in Feigin and Cherry's Textbook of Pediatric Infectious Diseases (01-01-2019)Get full text
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