Search Results - "Hanne, Jeungphill"
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Cascading MutS and MutL sliding clamps control DNA diffusion to activate mismatch repair
Published in Nature (London) (24-11-2016)“…MutS and MutL—the highly conserved core proteins responsible for the repair of mismatched DNA—form sequential stable sliding clamps that together modulate…”
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MutL sliding clamps coordinate exonuclease-independent Escherichia coli mismatch repair
Published in Nature communications (22-11-2019)“…A shared paradigm of mismatch repair (MMR) across biology depicts extensive exonuclease-driven strand-specific excision that begins at a distant…”
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ATP Alters the Diffusion Mechanics of MutS on Mismatched DNA
Published in Structure (London) (03-07-2012)“…The mismatch repair (MMR) initiation protein MutS forms at least two types of sliding clamps on DNA: a transient mismatch searching clamp (∼1 s) and an…”
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Dynamic control of strand excision during human DNA mismatch repair
Published in Proceedings of the National Academy of Sciences - PNAS (22-03-2016)“…Mismatch repair (MMR) is activated by evolutionarily conserved MutS homologs (MSH) and MutL homologs (MLH/PMS). MSH recognizes mismatched nucleotides and form…”
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Retroviral intasomes search for a target DNA by 1D diffusion which rarely results in integration
Published in Nature communications (25-04-2016)“…Retroviruses must integrate their linear viral cDNA into the host genome for a productive infection. Integration is catalysed by the retrovirus-encoded…”
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Repair of oxidative DNA base damage in the host genome influences the HIV integration site sequence preference
Published in PloS one (22-07-2014)“…Host base excision repair (BER) proteins that repair oxidative damage enhance HIV infection. These proteins include the oxidative DNA damage glycosylases…”
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DNA Mismatch Repair Relies Entirely on Stochastic Transactions
Published in Biophysical journal (01-02-2019)Get full text
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Dynamic unwrapping of nucleosomes by HsRAD51 that includes sliding and rotational motion of histone octamers
Published in Nucleic acids research (25-01-2017)“…Wrapping of genomic DNA into nucleosomes poses thermodynamic and kinetic barriers to biological processes such as replication, transcription, repair and…”
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Cascading MutS and MutL sliding clamps control DNA diffusion to activate mismatch repair
Published in Nature (London) (24-11-2016)“…Mismatched nucleotides arise from polymerase misincorporation errors, recombination between heteroallelic parents and chemical or physical DNA damage. Highly…”
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Muts Homolog Sliding Clamps Shield the DNA from Binding Proteins
Published in Biophysical journal (01-02-2019)Get full text
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MutS homolog sliding clamps shield the DNA from binding proteins
Published in The Journal of biological chemistry (14-09-2018)“…Sliding clamps on DNA consist of evolutionarily conserved enzymes that coordinate DNA replication, repair, and the cellular DNA damage response. MutS homolog…”
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Widespread nuclease contamination in commonly used oxygen-scavenging systems
Published in Nature methods (01-10-2015)Get full text
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13
Single-Molecule Studies on EXOI Excision during DNA Mismatch Repair
Published in Biophysical journal (16-02-2016)Get full text
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An Efficient Site-Specific Method for Irreversible Covalent Labeling of Proteins with a Fluorophore
Published in Scientific reports (19-11-2015)“…Fluorophore labeling of proteins while preserving native functions is essential for bulk Förster resonance energy transfer (FRET) interaction and single…”
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Mechanics of binding of a single integration-host-factor protein to DNA
Published in Physical review letters (25-03-2005)“…We report on a single-molecule experiment where we directly observe local bending of a 76 base pair DNA oligomer caused by specific binding of a single…”
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Plastic deformatin of protein monolayers
Published in Biophysical journal (01-10-2002)“…Globular proteins are peculiar solids that display both local stability of their conformation and the ability to undergo large cooperative changes of shape…”
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Plastic Deformation of Protein Monolayers
Published in Biophysical journal (01-10-2002)“…Globular proteins are peculiar solids that display both local stability of their conformation and the ability to undergo large cooperative changes of shape…”
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Opening rates of DNA hairpins: experiment and model
Published in Physical review. E, Statistical, nonlinear, and soft matter physics (01-07-2007)“…We present single-molecule measurements of the opening rate of DNA hairpins under mechanical tension and compare with the results obtained from a…”
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