Search Results - "Hannan, Nicholas RF"

Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells by Sampaziotis, Fotios, de Brito, Miguel Cardoso, Geti, Imbisaat, Bertero, Alessandro, Hannan, Nicholas RF, Vallier, Ludovic

“…This protocol describes how to recapitulate biliary development by differentiation of hPSCs into endoderm, foregut progenitor cells, hepatoblasts,…”
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Generation of functional hepatocytes from human embryonic stem cells under chemically defined conditions that recapitulate liver development by Touboul, Thomas, Hannan, Nicholas R. F., Corbineau, Sébastien, Martinez, Amélie, Martinet, Clémence, Branchereau, Sophie, Mainot, Sylvie, Strick‐Marchand, Hélène, Pedersen, Roger, Di Santo, James, Weber, Anne, Vallier, Ludovic

“…Generation of hepatocytes from human embryonic stem cells (hESCs) could represent an advantageous source of cells for cell therapy approaches as an alternative…”
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Optimized inducible shRNA and CRISPR/Cas9 platforms for in vitro studies of human development using hPSCs by Bertero, Alessandro, Pawlowski, Matthias, Ortmann, Daniel, Snijders, Kirsten, Yiangou, Loukia, Cardoso de Brito, Miguel, Brown, Stephanie, Bernard, William G, Cooper, James D, Giacomelli, Elisa, Gambardella, Laure, Hannan, Nicholas R F, Iyer, Dharini, Sampaziotis, Fotios, Serrano, Felipe, Zonneveld, Mariëlle C F, Sinha, Sanjay, Kotter, Mark, Vallier, Ludovic

“…Inducible loss of gene function experiments are necessary to uncover mechanisms underlying development, physiology and disease. However, current methods are…”
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hiPSC hepatocyte model demonstrates the role of unfolded protein response and inflammatory networks in α^sub 1^-antitrypsin deficiency by Segeritz, Charis-Patricia, Rashid, Sheikh Tamir, de Brito, Miguel Cardoso, Serra, Maria Paola, Ordonez, Adriana, Morell, Carola Maria, Kaserman, Joseph E, Madrigal, Pedro, Hannan, Nicholas RF, Gatto, Laurent, Tan, Lu, Wilson, Andrew A, Lilley, Kathryn, Marciniak, Stefan J, Gooptu, Bibek, Lomas, David A, Vallier, Ludovic

“…Background & Aims α1-Antitrypsin deficiency (A1ATD) is an autosomal recessive disorder caused by mutations in the SERPINA1 gene. Individuals with the Z variant…”
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Activation of the selenoprotein SEPS1 gene expression by pro-inflammatory cytokines in HepG2 cells by Gao, Yuan, Hannan, Nicholas R.F., Wanyonyi, Stephen, Konstantopolous, Nicky, Pagnon, Joanne, Feng, Helen C., Jowett, Jeremy B.M., Kim, Kee-Hong, Walder, Ken, Collier, Greg R.

“…SEPS1 (also called selenoprotein S, SelS) plays an important role in the production of inflammatory cytokines and its expression is activated by endoplasmic…”
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Targeted gene correction of alpha sub(1)-antitrypsin deficiency in induced pluripotent stem cells by Yusa, Kosuke, Rashid, STamir, Strick-Marchand, Helene, Varela, Ignacio, Liu, Pei-Qi, Paschon, David E, Miranda, Elena, Ordonez, Adriana, Hannan, Nicholas RF, Rouhani, Foad J, Darche, Sylvie, Alexander, Graeme, Marciniak, Stefan J, Fusaki, Noemi, Hasegawa, Mamoru, Holmes, Michael C, Di Santo, James P, Lomas, David A, Bradley, Allan, Vallier, Ludovic

“…Human induced pluripotent stem cells (iPSCs) represent a unique opportunity for regenerative medicine because they offer the prospect of generating unlimited…”
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