Search Results - "Hannan, Nicholas R.F"

Transplantation of Expanded Fetal Intestinal Progenitors Contributes to Colon Regeneration after Injury by Fordham, Robert P., Yui, Shiro, Hannan, Nicholas R.F., Soendergaard, Christoffer, Madgwick, Alison, Schweiger, Pawel J., Nielsen, Ole H., Vallier, Ludovic, Pedersen, Roger A., Nakamura, Tetsuya, Watanabe, Mamoru, Jensen, Kim B.

“…Regeneration and homeostasis in the adult intestinal epithelium is driven by proliferative resident stem cells, whose functional properties during organismal…”
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Generation of Multipotent Foregut Stem Cells from Human Pluripotent Stem Cells by Hannan, Nicholas R.F., Fordham, Robert P., Syed, Yasir A., Moignard, Victoria, Berry, Andrew, Bautista, Ruben, Hanley, Neil A., Jensen, Kim B., Vallier, Ludovic

“…Human pluripotent stem cells (hPSCs) could provide an infinite source of clinically relevant cells with potential applications in regenerative medicine…”
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Production of hepatocyte-like cells from human pluripotent stem cells by Hannan, Nicholas R F, Segeritz, Charis-Patricia, Touboul, Thomas, Vallier, Ludovic

“…Large-scale production of hepatocytes from a variety of genetic backgrounds would be beneficial for drug screening and to provide a source of cells to be used…”
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Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation by Sampaziotis, Fotios, Cardoso de Brito, Miguel, Madrigal, Pedro, Bertero, Alessandro, Saeb-Parsy, Kourosh, Soares, Filipa A C, Schrumpf, Elisabeth, Melum, Espen, Karlsen, Tom H, Bradley, J Andrew, Gelson, William T H, Davies, Susan, Baker, Alastair, Kaser, Arthur, Alexander, Graeme J, Hannan, Nicholas R F, Vallier, Ludovic

“…A protocol for generating biliary epithelial cells from human pluripotent stem cells facilitates disease modeling and drug screening. The study of biliary…”
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Regional Differences in Human Biliary Tissues and Corresponding In Vitro–Derived Organoids by Rimland, Casey A., Tilson, Samantha G., Morell, Carola M., Tomaz, Rute A., Lu, Wei‐Yu, Adams, Simone E., Georgakopoulos, Nikitas, Otaizo‐Carrasquero, Francisco, Myers, Timothy G., Ferdinand, John R., Gieseck, Richard L., Sampaziotis, Fotios, Tysoe, Olivia C., Ross, Alexander, Kraiczy, Judith M., Wesley, Brandon, Muraro, Daniele, Zilbauer, Matthias, Oniscu, Gabriel C., Hannan, Nicholas R.F., Forbes, Stuart J., Saeb‐Parsy, Kourosh, Wynn, Thomas A., Vallier, Ludovic

“…Background and Aims Organoids provide a powerful system to study epithelia in vitro. Recently, this approach was applied successfully to the biliary tree, a…”
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hiPSC hepatocyte model demonstrates the role of unfolded protein response and inflammatory networks in α1-antitrypsin deficiency by Segeritz, Charis-Patricia, Rashid, Sheikh Tamir, de Brito, Miguel Cardoso, Serra, Maria Paola, Ordonez, Adriana, Morell, Carola Maria, Kaserman, Joseph E., Madrigal, Pedro, Hannan, Nicholas R.F., Gatto, Laurent, Tan, Lu, Wilson, Andrew A., Lilley, Kathryn, Marciniak, Stefan J., Gooptu, Bibek, Lomas, David A., Vallier, Ludovic

“…[Display omitted] •Modelling liver disease due to α1-antitrypsin deficiency reveals disruption of the ER into isolated cisternae.•Comparative ‘omics’ between…”
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Identification and characterisation of a rare MTTP variant underlying hereditary non-alcoholic fatty liver disease by Grove, Jane I., Lo, Peggy C.K., Shrine, Nick, Barwell, Julian, Wain, Louise V., Tobin, Martin D., Salter, Andrew M., Borkar, Aditi N., Cuevas-Ocaña, Sara, Bennett, Neil, John, Catherine, Ntalla, Ioanna, Jones, Gabriela E., Neal, Christopher P., Thomas, Mervyn G., Kuht, Helen, Gupta, Pankaj, Vemala, Vishwaraj M., Grant, Allister, Adewoye, Adeolu B., Shenoy, Kotacherry T., Balakumaran, Leena K., Hollox, Edward J., Hannan, Nicholas R.F., Aithal, Guruprasad P.

“…Non-alcoholic fatty liver disease (NAFLD) is a complex trait with an estimated prevalence of 25% globally. We aimed to identify the genetic variant underlying…”
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Adipocyte differentiation in human embryonic stem cells transduced with Oct4 shRNA lentivirus by Hannan, Nicholas R F, Wolvetang, Ernst J

“…Oct4 is one of the master pluripotency genes that controls differentiation of human embryonic stem cells (hESCs). We generated HES2 and HES3 hESC lines stably…”
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Intestinal organoids for modelling intestinal development and disease by Fair, Kathryn L., Colquhoun, Jennifer, Hannan, Nicholas R. F.

“…Gastrointestinal diseases are becoming increasingly prevalent in developed countries. Immortalized cells and animal models have delivered important but limited…”
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Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells by Sampaziotis, Fotios, de Brito, Miguel Cardoso, Geti, Imbisaat, Bertero, Alessandro, Hannan, Nicholas RF, Vallier, Ludovic

“…This protocol describes how to recapitulate biliary development by differentiation of hPSCs into endoderm, foregut progenitor cells, hepatoblasts,…”
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Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids by Sampaziotis, Fotios, Justin, Alexander W, Tysoe, Olivia C, Sawiak, Stephen, Godfrey, Edmund M, Upponi, Sara S, Gieseck, Richard L, de Brito, Miguel Cardoso, Berntsen, Natalie Lie, Gómez-Vázquez, María J, Ortmann, Daniel, Yiangou, Loukia, Ross, Alexander, Bargehr, Johannes, Bertero, Alessandro, Zonneveld, Mariëlle C F, Pedersen, Marianne T, Pawlowski, Matthias, Valestrand, Laura, Madrigal, Pedro, Georgakopoulos, Nikitas, Pirmadjid, Negar, Skeldon, Gregor M, Casey, John, Shu, Wenmiao, Materek, Paulina M, Snijders, Kirsten E, Brown, Stephanie E, Rimland, Casey A, Simonic, Ingrid, Davies, Susan E, Jensen, Kim B, Zilbauer, Matthias, Gelson, William T H, Alexander, Graeme J, Sinha, Sanjay, Hannan, Nicholas R F, Wynn, Thomas A, Karlsen, Tom H, Melum, Espen, Markaki, Athina E, Saeb-Parsy, Kourosh, Vallier, Ludovic

“…Repair of defects in the common bile duct is hampered by a lack of healthy donor tissue. Developing human extrahepatic cholangiocyte organoids and testing them…”
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Generation of functional hepatocytes from human embryonic stem cells under chemically defined conditions that recapitulate liver development by Touboul, Thomas, Hannan, Nicholas R. F., Corbineau, Sébastien, Martinez, Amélie, Martinet, Clémence, Branchereau, Sophie, Mainot, Sylvie, Strick‐Marchand, Hélène, Pedersen, Roger, Di Santo, James, Weber, Anne, Vallier, Ludovic

“…Generation of hepatocytes from human embryonic stem cells (hESCs) could represent an advantageous source of cells for cell therapy approaches as an alternative…”
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Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells by Yusa, Kosuke, Rashid, S. Tamir, Strick-Marchand, Helene, Varela, Ignacio, Liu, Pei-Qi, Paschon, David E., Miranda, Elena, Ordóñez, Adriana, Hannan, Nicholas R. F., Rouhani, Foad J., Darche, Sylvie, Alexander, Graeme, Marciniak, Stefan J., Fusaki, Noemi, Hasegawa, Mamoru, Holmes, Michael C., Di Santo, James P., Lomas, David A., Bradley, Allan, Vallier, Ludovic

“…Fixing the genes in iPS cells Before human induced pluripotent stem (iPS) cells can be used to treat genetically inherited human disease, it will be necessary…”
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Maturation of induced pluripotent stem cell derived hepatocytes by 3D-culture by Gieseck, 3rd, Richard L, Hannan, Nicholas R F, Bort, Roque, Hanley, Neil A, Drake, Rosemary A L, Cameron, Grant W W, Wynn, Thomas A, Vallier, Ludovic

“…Induced pluripotent stem cell derived hepatocytes (IPSC-Heps) have the potential to reduce the demand for a dwindling number of primary cells used in…”
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In Vitro and in Vivo Assays for Testing Retinoids Effect on Intestinal Progenitors' Lineage Commitments by Gajera, Krishna R, Fair, Kathryn L, Moran, Gordon W, Hannan, Nicholas R F, Huelsken, Joerg, Ordóñez-Morán, Paloma

“…The intestine consists of epithelial cells surrounded by a complex environment as mesenchymal cells and the gut microbiota. With its impressive stem cell…”
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Optimized inducible shRNA and CRISPR/Cas9 platforms for in vitro studies of human development using hPSCs by Bertero, Alessandro, Pawlowski, Matthias, Ortmann, Daniel, Snijders, Kirsten, Yiangou, Loukia, Cardoso de Brito, Miguel, Brown, Stephanie, Bernard, William G, Cooper, James D, Giacomelli, Elisa, Gambardella, Laure, Hannan, Nicholas R F, Iyer, Dharini, Sampaziotis, Fotios, Serrano, Felipe, Zonneveld, Mariëlle C F, Sinha, Sanjay, Kotter, Mark, Vallier, Ludovic

“…Inducible loss of gene function experiments are necessary to uncover mechanisms underlying development, physiology and disease. However, current methods are…”
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A Cell-Based Optimised Approach for Rapid and Efficient Gene Editing of Human Pluripotent Stem Cells by Cuevas-Ocaña, Sara, Yang, Jin Ye, Aushev, Magomet, Schlossmacher, George, Bear, Christine E, Hannan, Nicholas R F, Perkins, Neil D, Rossant, Janet, Wong, Amy P, Gray, Michael A

“…Introducing or correcting disease-causing mutations through genome editing in human pluripotent stem cells (hPSCs) followed by tissue-specific differentiation…”
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Generation of Distal Airway Epithelium from Multipotent Human Foregut Stem Cells by Hannan, Nicholas R F, Sampaziotis, Fotios, Segeritz, Charis-Patricia, Hanley, Neil A, Vallier, Ludovic

“…Collectively, lung diseases are one of the largest causes of premature death worldwide and represent a major focus in the field of regenerative medicine…”
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Disease modeling using human induced pluripotent stem cells: Lessons from the liver by Gieseck, Richard L., Colquhoun, Jennifer, Hannan, Nicholas R.F.

“…Human pluripotent stem cells (hPSCs) have the capacity to differentiate into any of the hundreds of distinct cell types that comprise the human body. This…”
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Dynamics of 5-carboxylcytosine during hepatic differentiation: Potential general role for active demethylation by DNA repair in lineage specification by Lewis, Lara C., Lo, Peggy Cho Kiu, Foster, Jeremy M., Dai, Nan, Corrêa, Ivan R., Durczak, Paulina M., Duncan, Gary, Ramsawhook, Ashley, Aithal, Guruprasad Padur, Denning, Chris, Hannan, Nicholas R. F., Ruzov, Alexey

“…Patterns of DNA methylation (5-methylcytosine, 5mC) are rearranged during differentiation contributing to the regulation of cell type-specific gene expression…”
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