Search Results - "Hannan, A J"

Chronically high stress hormone levels dysregulate sperm long noncoding RNAs and their embryonic microinjection alters development and affective behaviours by Hoffmann, L. B., Li, B., Zhao, Q., Wei, W., Leighton, L. J., Bredy, T. W., Pang, T. Y., Hannan, A. J.

“…Previous studies on paternal epigenetic inheritance have shown that sperm RNAs play a role in this type of inheritance. The microinjection of sperm small…”
Get full text

Review: Environmental enrichment and brain repair: harnessing the therapeutic effects of cognitive stimulation and physical activity to enhance experience-dependent plasticity by Hannan, A. J.

“…Environmental enrichment (EE) increases levels of novelty and complexity, inducing enhanced sensory, cognitive and motor stimulation. In wild‐type rodents, EE…”
Get full text

Differential effects of voluntary physical exercise on behavioral and brain-derived neurotrophic factor expression deficits in huntington’s disease transgenic mice by Pang, T.Y.C., Stam, N.C., Nithianantharajah, J., Howard, M.L., Hannan, A.J.

“…Huntington’s disease is a fatal neurodegenerative disorder caused by a mutation of the huntingtin gene and involves progressive motor abnormalities (including…”
Get full text

Phospholipase C-β1 knockout mice exhibit endophenotypes modeling schizophrenia which are rescued by environmental enrichment and clozapine administration by McOmish, C E, Burrows, E, Howard, M, Scarr, E, Kim, D, Shin, H-S, Dean, B, van den Buuse, M, Hannan, A J

“…Phospholipase C- β 1 (PLC- β 1) is a rate-limiting enzyme implicated in postnatal-cortical development and neuronal plasticity. PLC- β 1 transduces…”
Get full text

Delayed onset of Huntington's disease in mice in an enriched environment correlates with delayed loss of cannabinoid CB1 receptors by GLASS, M, VAN DELLEN, A, BLAKEMORE, C, HANNAN, A. J, FAULL, R. L. M

“…Huntington's disease (HD) is a late onset progressive genetic disorder characterised by motor dysfunction, personality changes, dementia and premature death…”
Get full text

Altered CB1 receptor and endocannabinoid levels precede motor symptom onset in a transgenic mouse model of Huntington's disease by Dowie, M.J, Bradshaw, H.B, Howard, M.L, Nicholson, L.F.B, Faull, R.L.M, Hannan, A.J, Glass, M

“…Abstract Huntington's disease (HD) is an inherited neurodegenerative disease characterised by cell dysfunction and death in the basal ganglia and cortex…”
Get full text

Therapeutic Potential of Cannabinoids on Tumor Microenvironment: A Molecular Switch in Neoplasia Transformation by Bakshi, Hamid A., Faruck, Hakkim L., Ravesh, Zeinab, Ansari, Prawej, Hannan, J. M. A., Hashimoto, Rina, Takayama, Kazuo, Farzand, Rabia, Nasef, Mohamed M., Mensah, Adelaide, Aljabali, Alaa A. A., Mishra, Vijay, Charbe, Nitin B., Goyal, Rohit, Negi, Poonam, Serrano-Aroca, Ángel, Bahar, Bojlul, El-Tanani, Mohamed, Courtenay, Aaron J., McCarron, Paul, Jack, Iain G., Tambuwala, Murtaza M.

“…The efficacy of chemotherapy depends on the tumor microenvironment. This microenvironment consists of a complex cellular network that can exert both…”
Get full text

Deficits in Spermatogenesis but not Neurogenesis are Alleviated by Chronic Testosterone Therapy in R6/1 Huntington's Disease Mice by Hannan, A. J., Ransome, M. I.

“…Despite the well established central pathophysiology of Huntington’s disease (HD), less is known about systemic impairments that are emerging as significant…”
Get full text

Aqueous fraction of Beta vulgaris ameliorates hyperglycemia in diabetic mice due to enhanced glucose stimulated insulin secretion, mediated by acetylcholine and GLP-1, and elevated glucose uptake via increased membrane bound GLUT4 transporters by Ul Kabir, Ashraf, Samad, Mehdi Bin, Ahmed, Arif, Jahan, Mohammad Rajib, Akhter, Farjana, Tasnim, Jinat, Hasan, S M Nageeb, Sayfe, Sania Sarker, Hannan, J M A

“…The study was designed to investigate the probable mechanisms of anti-hyperglycemic activity of B. Vulgaris. Aqueous fraction of B. Vulgaris extract was the…”
Get full text

Behavioural and molecular consequences of chronic cannabinoid treatment in Huntington's disease transgenic mice by Dowie, M.J, Howard, M.L, Nicholson, L.F.B, Faull, R.L.M, Hannan, A.J, Glass, M

“…Abstract Early loss of CB1 receptors is a hallmark of human Huntington's disease. Data from rodent studies suggest that preservation and activation of CB1…”
Get full text

Dissociating the therapeutic effects of environmental enrichment and exercise in a mouse model of anxiety with cognitive impairment by Rogers, J, Vo, U, Buret, LS, Pang, TY, Meiklejohn, H, Zeleznikow-Johnston, A, Churilov, L, van den Buuse, M, Hannan, AJ, Renoir, T

“…Clinical evidence indicates that serotonin-1A receptor (5-HT 1A R) gene polymorphisms are associated with anxiety disorders and deficits in cognition. In…”
Get full text

Pharmacologically Active Phytomolecules Isolated from Traditional Antidiabetic Plants and Their Therapeutic Role for the Management of Diabetes Mellitus by Ansari, Prawej, Akther, Samia, Hannan, J. M. A., Seidel, Veronique, Nujat, Nusrat Jahan, Abdel-Wahab, Yasser H. A.

“…Diabetes mellitus is a chronic complication that affects people of all ages. The increased prevalence of diabetes worldwide has led to the development of…”
Get full text

Social Isolation Alters Social and Mating Behavior in the R451C Neuroligin Mouse Model of Autism by Hannan, Anthony J., McLachlan, N. M., Hill, T., Kolbe, Scott C., May, C., Eastwood, A. F., Burrows, E. L., Churilov, Leonid

“…Autism spectrum disorder (ASD) is a neurodevelopmental disorder typified by impaired social communication and restrictive and repetitive behaviors. Mice serve…”
Get full text

Metabotropic glutamate receptors as targets for novel antipsychotic treatments by Gray, L J, Hannan, A J, Zhang, X

“…In recent years metabotropic glutamate receptors have emerged as key targets for the design of new antipsychotic medications for schizophrenia, in particular…”
Get more information

Insulin secretory actions of extracts of Asparagus racemosus root in perfused pancreas, isolated islets and clonal pancreatic β-cells by Hannan, J M A, Marenah, Lamin, Ali, Liaquat, Rokeya, Begum, Flatt, Peter R, Abdel-Wahab, Yasser H

“…Asparagus racemosus root has previously been reported to reduce blood glucose in rats and rabbits. In the present study, the effects of the ethanol extract and…”
Get full text

Attenuated responses to attention-modulating drugs in the neuroligin-3 R451C mouse model of autism by Dingwall, R, May, C, Letschert, J, Renoir, T, Hannan, A J, Burrows, E L

“…Attention deficits are frequently reported within the clinical autism population. Despite not being a core diagnostic feature, some aetiological theories place…”
Get full text

Attenuated responses to attention‐modulating drugs in the neuroligin‐3R451C mouse model of autism by Dingwall, R., May, C., Letschert, J., Renoir, T., Hannan, A. J., Burrows, E. L.

“…Attention deficits are frequently reported within the clinical autism population. Despite not being a core diagnostic feature, some aetiological theories place…”
Get full text

Therapeutic Potential of Quercetin in the Management of Type-2 Diabetes Mellitus by Ansari, Prawej, Choudhury, Samara T., Seidel, Veronique, Rahman, Akib Bin, Aziz, Md. Abdul, Richi, Anika E., Rahman, Ayesha, Jafrin, Umme H., Hannan, J. M. A., Abdel-Wahab, Yasser H. A.

“…Diabetes Mellitus (DM) is a metabolic disorder that is spreading alarmingly around the globe. Type-2 DM (T2DM) is characterized by low-grade inflammation and…”
Get full text

Dysregulation of synaptic proteins, dendritic spine abnormalities and pathological plasticity of synapses as experience-dependent mediators of cognitive and psychiatric symptoms in Huntington’s disease by Nithianantharajah, J, Hannan, A.J

“…Highlights ► Transgenic mouse models of Huntington’s disease (HD) exhibit abnormalities at dendritic spines and synapses. ► Evidence for HD as a ‘synaptopathy’…”
Get full text

Assessing attention orienting in mice: a novel touchscreen adaptation of the Posner-style cueing task by Li, S, May, C, Hannan, A J, Johnson, K A, Burrows, E L

“…Atypical attention orienting has been found to be impaired in many neuropsychological disorders, but the underlying neural mechanism remains unclear. Attention…”
Get full text