Search Results - "Hannam, Joanne C."

Thiyl radical induced isomerisations of maleate esters provide a convenient route to fumarates and furanones by Harrowven, David C., Hannam, Joanne C.

“…Maleate esters can be converted into fumarate esters in near quantitative yield through exposure to thiyl radicals generated in refluxing hexane by photolysis…”
Get full text

A thiyl radical mediated cascade sequence for the co-cyclisation of 1,6-hexadienes with sulfur atom transfer by Harrowven, David C, Hannam, Joanne C, Lucas, Matthew C, Newman, Nicola A, Howes, Peter D

“…The paper describes a method for effecting the co-cyclisation of 1,6-dienes with concomitant sulfur atom transfer. The key step is a cascade reaction involving…”
Get full text

Apoptosis in T Cell Acute Lymphoblastic Leukemia Cells after Cell Cycle Arrest Induced by Pharmacological Inhibition of Notch Signaling by Lewis, Huw D., Leveridge, Matthew, Strack, Peter R., Haldon, Christine D., O'Neil, Jennifer, Kim, Hellen, Madin, Andrew, Hannam, Joanne C., Look, A. Thomas, Kohl, Nancy, Draetta, Giulio, Harrison, Timothy, Kerby, Julie A., Shearman, Mark S., Beher, Dirk

“…In this report, inhibitors of the γ-secretase enzyme have been exploited to characterize the antiproliferative relationship between target inhibition and…”
Get full text

A short synthesis of α-herbertenol featuring the use of a dihydropyranone as a 1,5-diketone synthon by Harrowven, David C., Hannam, Joanne C.

“…The paper describes a short synthesis of α-herbertenol. Key features are the addition of dihyropyranone 5 to an aryllithium to give 1,5-diketone 7; a…”
Get full text

1,5-Diketones from 3,4-dihydropyranones: An application in the synthesis of (±)-α-herbertenol by Harrowven, David C., Hannam, Joanne C.

“…An approach to 1,5-diketones involving the addition of organolithium reagents to 3,4-dihydropyranones is described. Good yields are obtained when reactions are…”
Get full text