Search Results - "Hannam, Jeffrey S."

Expanding the Toolbox of Photoswitches for DNA Nanotechnology Using Arylazopyrazoles by Adam, Volker, Prusty, Deepak K., Centola, Mathias, Škugor, Marko, Hannam, Jeffrey S., Valero, Julián, Klöckner, Bernhard, Famulok, Michael

“…Photoregulation is among the most promising tools for development of dynamic DNA nanosystems, due to its high spatiotemporal precision, biocompatibility, and…”
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Anti-proliferative effect of cytohesin inhibition in gefitinib-resistant lung cancer cells by Bill, Anke, Schmitz, Anton, König, Katharina, Heukamp, Lukas C, Hannam, Jeffrey S, Famulok, Michael

“…Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI), such as gefitinib, have been proven to efficiently inhibit the proliferation of a…”
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Shaping of a Conformationally Flexible Molecular Structure for Spectroscopy by Rijs, Anouk M, Crews, Bridgit O, de Vries, Mattanjah S, Hannam, Jeffrey S, Leigh, David A, Fanti, Marianna, Zerbetto, Francesco, Buma, Wybren J

“…Chaperones for wild molecules: A molecule's conformational flexibility can be eliminated by enclosing it with a macrocyclic mold as a [2]rotaxane (see picture)…”
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Controlled Submolecular Translational Motion in Synthesis: A Mechanically Interlocking Auxiliary by Hannam, Jeffrey S., Lacy, Stephen M., Leigh, David A., Saiz, Carlos G., Slawin, Alexandra M. Z., Stitchell, Sheila G.

“…Sew simple: How can you put a molecular bead on a thread when no recognition elements exist between them? A mechanically interlocking auxiliary assembles the…”
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Studying the Conformation of a Receptor Tyrosine Kinase in Solution by Inhibitor‐Based Spin Labeling by Yin, Dongsheng M., Hannam, Jeffrey S., Schmitz, Anton, Schiemann, Olav, Hagelueken, Gregor, Famulok, Michael

“…The synthesis of a spin label based on PD168393, a covalent inhibitor of a major anticancer drug target, the epidermal growth factor receptor (EGFR), is…”
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Studying the Conformation of a Receptor Tyrosine Kinase in Solution by Inhibitor‐Based Spin Labeling by Yin, Dongsheng M., Hannam, Jeffrey S., Schmitz, Anton, Schiemann, Olav, Hagelueken, Gregor, Famulok, Michael

“…The synthesis of a spin label based on PD168393, a covalent inhibitor of a major anticancer drug target, the epidermal growth factor receptor (EGFR), is…”
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“Magic Rod” Rotaxanes:  The Hydrogen Bond-Directed Synthesis of Molecular Shuttles under Thermodynamic Control by Hannam, Jeffrey S, Kidd, Timothy J, Leigh, David A, Wilson, Andrew J

“…Peptide [2]- and [3]rotaxanes are assembled in high yields under thermodynamic control using hydrogen bonding interactions and reversible cross olefin…”
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Probing the Structure of a Rotaxane with Two-Dimensional Infrared Spectroscopy by Olaf F. A. Larsen, Bodis, Pavol, Buma, Wybren Jan, Hannam, Jeffrey S., Leigh, David A., Woutersen, Sander, Crim, F. Fleming

“…Femtosecond 2D-IR spectroscopy has been used to study the structure of a [2]rotaxane composed of a benzylic amide macrocycle that is mechanically interlocked…”
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A double-stranded DNA rotaxane by Ackermann, Damian, Schmidt, Thorsten L., Hannam, Jeffrey S., Purohit, Chandra S., Heckel, Alexander, Famulok, Michael

“…Mechanically interlocked molecules such as rotaxanes and catenanes have potential as components of molecular machinery. Rotaxanes consist of a dumb-bell-shaped…”
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Controlled Hydrogen-Bond Breaking in a Rotaxane by Discrete Solvation by Rijs, Anouk M, Sändig, Nadja, Blom, Martine N, Oomens, Jos, Hannam, Jeffrey S, Leigh, David A, Zerbetto, Francesco, Buma, Wybren J

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A trifluoromethylphenyl diazirine-based SecinH3 photoaffinity probe by Albertoni, Barbara, Hannam, Jeffrey S, Ackermann, Damian, Schmitz, Anton, Famulok, Michael

“…The synthesis of a trifluoromethylphenyl diazirine photoaffinity probe of the cytohesin inhibitor SecinH3 is described. The probe exhibits improved labelling…”
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Stiff, and Sticky in the Right Places: Binding Interactions in Isolated Mechanically Interlocked Molecules Probed by Mid-Infrared Spectroscopy by Rijs, Anouk M, Compagnon, Isabelle, Oomens, Jos, Hannam, Jeffrey S, Leigh, David A, Buma, Wybren J

“…We report the results of high-resolution spectroscopic studies on isolated, jet-cooled [2]rotaxanes. Employing IR absorption spectroscopy, we show how these…”
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Cyplecksins Are Covalent Inhibitors of the Pleckstrin Homology Domain of Cytohesin by Hussein, Mohamed, Bettio, Martina, Schmitz, Anton, Hannam, Jeffrey S., Theis, Julian, Mayer, Günter, Dosa, Stefan, Gütschow, Michael, Famulok, Michael

“…The covalent grip: A new class of 5‐bromobarbiturates (Cyplecksins; see structure) act by a covalent mechanism to inhibit the biological function of the…”
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wALADin Benzimidazoles Differentially Modulate the Function of Porphobilinogen Synthase Orthologs by Lentz, Christian S, Halls, Victoria S, Hannam, Jeffrey S, Strassel, Silke, Lawrence, Sarah H, Jaffe, Eileen K, Famulok, Michael, Hoerauf, Achim, Pfarr, Kenneth M

“…The heme biosynthesis enzyme porphobilinogen synthase (PBGS) is a potential drug target in several human pathogens. wALADin1 benzimidazoles have emerged as…”
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In vitro activity of wALADin benzimidazoles against different life cycle stages of Plasmodium parasites by Lentz, Christian S, Sattler, Julia M, Fendler, Martina, Gottwalt, Simon, Halls, Victoria S, Strassel, Silke, Arriens, Sandra, Hannam, Jeffrey S, Specht, Sabine, Famulok, Michael, Mueller, Ann-Kristin, Hoerauf, Achim, Pfarr, Kenneth M

“…wALADin1 benzimidazoles are specific inhibitors of δ-aminolevulinic acid dehydratase from Wolbachia endobacteria of filarial nematodes. We report that wALADin1…”
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Conformational Flexibility of a Rotaxane Thread Probed by Electronic Spectroscopy in Helium Nanodroplets by Smolarek, Szymon, Rijs, Anouk M, Hannam, Jeffrey S, Leigh, David A, Drabbels, Marcel, Buma, Wybren J

“…Ultrahigh-resolution spectroscopic studies have been performed to elucidate the conformational landscape of the succinamide-based thread 1 that is frequently…”
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Heterovibrational Interactions, Cooperative Hydrogen Bonding, and Vibrational Energy Relaxation Pathways in a Rotaxane by Bodis, Pavol, Timmer, Rutger, Yeremenko, Sergey, Buma, Wybren Jan, Hannam, Jeffrey S, Leigh, David A, Woutersen, Sander

“…Femtosecond two-color vibrational pump−probe spectroscopy is used to investigate the interaction between the NH- and CO-stretch vibrations in a rotaxane…”
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A Selective Inhibitor of Heme Biosynthesis in Endosymbiotic Bacteria Elicits Antifilarial Activity In Vitro by Lentz, Christian S., Halls, Victoria, Hannam, Jeffrey S., Niebel, Björn, Strübing, Uta, Mayer, Günter, Hoerauf, Achim, Famulok, Michael, Pfarr, Kenneth M.

“…Lymphatic filariasis and onchocerciasis are severe diseases caused by filarial worms and affect more than 150 million people worldwide. Endosymbiotic…”
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Kovalente Inhibition der Pleckstrin-Homologiedomäne von Cytohesinen durch Cyplecksine by Hussein, Mohamed, Bettio, Martina, Schmitz, Anton, Hannam, Jeffrey S., Theis, Julian, Mayer, Günter, Dosa, Stefan, Gütschow, Michael, Famulok, Michael

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Controlled Submolecular Translational Motion in Synthesis: A Mechanically Interlocking Auxiliary by Hannam, Jeffrey S., Lacy, Stephen M., Leigh, David A., Saiz, Carlos G., Slawin, Alexandra M. Z., Stitchell, Sheila G.

“…Geschickt eingefädelt: Keine Erkennung zwischen den Komponenten ist für das hier beschriebene molekulare Einfädeln nötig. Ein Auxiliar fixiert den Makrocyclus…”
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