Search Results - "Hanna, Naeem B."

Elimination of transamination side product by the use of dCAc methylphosphonamidite in the synthesis of oligonucleoside methylphosphonates by Reddy, M.P, Farooqui, Firdous, Hanna, Naeem B

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Sulfinosine congeners: synthesis and antitumor activity in mice of certain N9-alkylpurines and purine ribonucleosides by Hanna, Naeem B, Bhattacharya, Birendra K, Robins, Roland K, Avery, Thomas L, Revankar, Ganapathi R

“…A number of N9-alkyl-substituted purines and purine ribonucleosides have been synthesized as congeners of sulfinosine and evaluated for their antileukemic…”
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Synthesis and antitumor evaluation in mice of certain 7-deazapurine (pyrrolo[2,3-d]pyrimidine) and 3-deazapurine (imidazo[4,5-c]pyridine) nucleosides structurally related to sulfenosine, sulfinosine, and sulfonosine by Ramasamy, Kandasamy, Imamura, Nobutaka, Hanna, Naeem B, Finch, Rick A, Avery, Thomas L, Robins, Roland K, Revankar, Ganapathi R

“…7-Deaza (pyrrolo[2,3-d]pyrimidine) and 3-deaza (imidazo[4,5-c]pyridine) congeners of sulfenosine (5a and 9), sulfinosine (6a and 10), and sulfonosine (7a) have…”
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Synthesis and in vivo antitumor activity of 2-amino-9H-purine-6-sulfenamide, -sulfinamide, and -sulfonamide and related purine ribonucleosides by Revankar, Ganapathi R, Hanna, Naeem B, Imamura, Nobutaka, Lewis, Arthur F, Larson, Steven B, Finch, Rick A, Avery, Thomas L, Robins, Roland K

“…A number of 6-sulfenamide, 6-sulfinamide, and 6-sulfonamide derivatives of 2-aminopurine and certain related purine ribonucleosides have been synthesized and…”
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Analysis of the in vitro antitumor activity of novel purine-6-sulfenamide, -sulfinamide, and -sulfonamide nucleosides and certain related compounds using a computer-aided receptor modeling procedure by Viswanadhan, Vellarkad N, Ghose, Arup K, Hanna, Naeem B, Matsumoto, Steven S, Avery, Thomas L, Revankar, Ganapathi R, Robins, Roland K

“…The comparative antileukemic activities of 21 novel nucleosides were determined in vitro by using cultured L1210 cells and analyzed for structure-related…”
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Synthesis and evaluation of 5-amino-1-.beta.-D-ribofuranosyl-1,2,4-triazole-3-carboxamidine and certain related nucleosides as inhibitors of purine nucleoside phosphorylase by Sanghvi, Yogesh S, Hanna, Naeem B, Larson, Steven B, Fujitaki, James M, Willis, Randall C, Smith, Roberts A, Robins, Roland K, Revankar, Ganapathi R

“…The 5-amino and certain related derivatives of the powerful purine nucleoside phosphorylase (PNPase) inhibitor…”
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Elimination of transamination side product by the use of dC Ac methylphosphonamidite in the synthesis of oligonucleoside methylphosphonates by Reddy, M.P, Farooqui, Firdous, Hanna, Naeem B

“…The transamination side product formed by the use of dC bz or dC ibu methylphosphonamidite upon treatment with ethylenediamine has been eliminated by the use…”
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Methylamine deprotection provides increased yield of oligoribonucleotides by Reddy, M.P., Farooqui, Firdous, Hanna, Naeem B.

“…Use of methylamine or methylamine/ammonium hydroxide as a cleavage and deprotection reagent for the solid phase synthesis of Oligoribonucleotides has…”
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Synthesis of N4-Amino and N4-Hydroxy Derivatives of 5-Azacytidine. A Facile Rearrangement of the N4-Amino Derivative to 5-(3-β-D-Ribofuranosylureido)-1H-1,2,4-triazole by Pískala, Alois, Hanna, Naeem B., Masojídková, Milena, Fiedler, Pavel, Votruba, Ivan

“…Treatment of methoxyribosyltriazinone 4 with hydrazine in methanol afforded crude 4-hydrazino-1-β-D-ribofuranosyl-1,3,5-triazin-2( 1H )-one ( N 4…”
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Synthesis of N4-Alkyl-5-azacytidines and Their Base-Pairing with Carbamoylguanidines - A Contribution to Explanation of the Mutagenicity of 2'-Deoxy-5-azacytidine by Pískala, Alois, Hanna, Naeem B., Masojídková, Milena, Otmar, Miroslav, Fiedler, Pavel, Ubik, Karel

“…A series of N 4 -alkyl-5-azacytidines 3a - 3h were prepared by treatment of the 4-methoxy analogue 4 with the respective amines. In the case of propyl-,…”
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Synthesis and Biological Activity of N4-Methyl-5-azacytidines by Hanna, Naeem B., Masojídková, Milena, Pískala, Alois

“…Protected N 4 -methyl and N 4 , N 4 -dimethyl derivatives of 5-azacytidine 3 and 4 were prepared by selective aminolysis of benzoylated…”
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Synthesis of Some 6-Substituted 5-Azacytidines by Hanna, Naeem B., Masojídková, Milena, Fiedler, Pavel, Pískala, Alois

“…Protected 6-substituted benzyl, phenyl and chloromethyl derivatives of 5-azacytidine 8-10 have been prepared by addition of phenylacetyl- ( 2 ), benzoyl- ( 3 )…”
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Chemotherapeutic characterization in mice of 2-amino-9-β-D-ribofuranosylpurine-6-sulfinamide (sulfinosine), a novel purine nucleoside with unique antitumor properties by AVERY, T. L, FINCH, R. A, VASQUEZ, K. M, RADPARVAR, S, HANNA, N. B, REVANKAR, G. R, ROBINS, R. K

“…In preclinical investigations performed in mice, 2-amino-9-beta-D-ribofuranosyl purine-6-sulfinamide (sulfinosine), a novel derivative of 6-thioguanosine…”
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A convenient synthesis of 2′-deoxy-6-thioguanosine, ara-guanine, ara-6-thioguanine and certain related purine nucleosides by the stereospecific sodium salt glycosylation procedure by Hanna, Naeem B., Ramasamy, Kandasamy, Robins, Roland K., Revankar, Ganapathi R.

“…A simple and high‐yield synthesis of biologically significant 2′‐deoxy‐6‐thioguanosine (11), ara‐6‐thioguanine (16) and araG (17) has been accomplished…”
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Synthesis and single-crystal X-ray diffraction studies of 1-β-D-ribofuranosyl-1,2,4-triazole-3-sulfonamide and certain related nucleosides by Hanna, Naeem B., Dimitrijevich, Slobodan D., Larson, Steven B., Robins, Roland K., Revankar, Ganapathi R.

“…1‐β‐D‐Ribofuranosyl‐ 21, 1‐(2‐deoxy‐β‐D‐erytftro‐pentofuranosyl)‐ 27 and 1‐β‐D‐arabinofuranosyl‐ 29 derivatives of 1,2,4‐triazole‐3‐sulfonamide (19) have been…”
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Synthesis of 5'-O-beta-D-glucopyranosyl and 5'-O-beta-D-galactopyranosyl derivatives of ribavirin by Hanna, N B, Robins, R K, Revankar, G R

“…The synthesis of 5'-O-beta-D-glucopyranosyl and 5'-O-beta-D-galactopyranosyl derivatives (13 and 15, respectively) of the antiviral agent ribavirin are…”
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Synthesis and In Vivo antitumor and antiviral activities of 2′-deoxyribofuranosyl and arabinofuranosyl nucleosides of certain purine-6-sulfenamides, sulfinamides and sulfonamides by Revankar, Ganapathi R., Hanna, Naeem B., Ramasamy, Kandasamy, Larson, Steven B., Smee, Donald F., Finch, Rick A., Avery, Thomas L., Robins, Roland K.

“…2′‐Deoxyribofuranosyl and arabinofuranosyl nucleosides of certain purine‐6‐sulfenamides, sulfinamides and sulfonamides have been prepared by sequential…”
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Synthesis and single-crystal X-ray diffraction analysis of 2-sulfamoyladenosine (6-amino-9-β-D-ribofuranosylpurine-2-sulfonamide) by Hanna, Naeem B., Larson, Steven B., Robins, Roland K., Revankar, Ganapathi R.

“…2‐Amino‐9‐β‐D‐ribofuranosylpurine‐2‐sulfonamide (2‐sulfamoyladenosine, 4), a congener of sulfonosine (3), was synthesized by four different routes. Acid…”
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Synthesis, molecular conformation and biological activity of 6-amino-5-azacytidine by PISKALA, A, HANNA, N. B, ZAJICEK, J, CIHAK, A

“…Reaction of N-ethoxycarbonylguanidine III with 2,3,5-tri-O-benzoyl-β-D-ribosyl isocyanate ( II ) afforded N-ethoxycarbonylamidinourea IV , which was cyclized…”
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Synthesis of certain 1-β-D-ribofuranosyl-1,2-dihydro-2-oxopyridines structurally related to nicotinamide ribonucleoside by Hanna, Naeem B., Joshi, Ramachandra V., Larson, Steven B., Robins, Roland K., Revankar, Ganapathi R.

“…Several substituted 1‐β‐D‐ribofuranosyl‐1,2‐dihydro‐2‐oxopyridines have been prepared as congeners of nicotinamide ribonucleoside. Direct glycosylation of the…”
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