Search Results - "Hanna, Kozłowska"
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Cannabidiol Improves Antioxidant Capacity and Reduces Inflammation in the Lungs of Rats with Monocrotaline-Induced Pulmonary Hypertension
Published in Molecules (Basel, Switzerland) (22-05-2022)“…Cannabidiol (CBD) is a plant-derived compound with antioxidant and anti-inflammatory properties. Pulmonary hypertension (PH) is still an incurable disease. CBD…”
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2
Modulation of Cardiovascular Function in Primary Hypertension in Rat by SKA-31, an Activator of KCa2.x and KCa3.1 Channels
Published in International journal of molecular sciences (23-08-2019)“…The aim of this study was to investigate the hemodynamic effects of SKA-31, an activator of the small (KCa2.x) and intermediate (KCa3.1) conductance…”
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3
Cellular Vaccines Modified with Hyper IL6 or Hyper IL11 Combined with Docetaxel in an Orthotopic Prostate Cancer Model
Published in Anticancer research (01-06-2015)“…Whole-cell-based vaccines modified with Hyper-IL-6 (H6) and Hyper-IL-11 (H11) have demonstrated high activity in murine melanoma and renal cancer models. H6…”
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4
Endotoxin reduction from biotech silk material inhibits the production of anti‐silk antibodies in mice
Published in Journal of biomedical materials research. Part A (01-03-2024)“…Eliminating endotoxins is a common problem in the development of biotechnologically produced pharmaceuticals or biomaterials. Residual endotoxins in the final…”
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5
The potential of cannabinoids and inhibitors of endocannabinoid degradation in respiratory diseases
Published in European journal of pharmacology (15-11-2021)“…The global incidence of respiratory diseases and complications is increasing. Therefore, new methods of treatment, as well as prevention, need to be…”
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Cannabidiol alleviates right ventricular fibrosis by inhibiting the transforming growth factor β pathway in monocrotaline-induced pulmonary hypertension in rats
Published in Biochimica et biophysica acta. Molecular basis of disease (01-08-2023)“…Cannabidiol (CBD) is a non-intoxicating compound of Cannabis with anti-fibrotic properties. Pulmonary hypertension (PH) is a disease that can lead to right…”
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7
Neuron-derived factors negatively modulate ryanodine receptor-mediated calcium release in cultured mouse astrocytes
Published in Cell calcium (Edinburgh) (01-12-2020)“…[Display omitted] •RyR agonist caffeine (caf) evoked [Ca2+]i rise in cultured mouse astrocytes.•A 24 h incubation in neuron-conditioned medium (NCM) abolished…”
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Vasodilatory effects of cannabidiol in human pulmonary and rat small mesenteric arteries: modification by hypertension and the potential pharmacological opportunities
Published in Journal of hypertension (01-05-2020)“…OBJECTIVE:Cannabidiol (CBD) has been suggested as a potential antihypertensive drug. The aim of our study was to investigate its vasodilatory effect in…”
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Cannabidiol inhibits lung proliferation in monocrotaline-induced pulmonary hypertension in rats
Published in Biomedicine & pharmacotherapy (01-03-2023)“…Cannabidiol (CBD) is a safe and well-tolerated plant-derived drug with anti-proliferative properties. Pulmonary hypertension (PH) is a rapidly progressive and…”
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10
Cannabinoids—A New Perspective in Adjuvant Therapy for Pulmonary Hypertension
Published in International journal of molecular sciences (17-09-2021)“…Currently, no treatment can completely cure pulmonary hypertension (PH), which can lead to right ventricular failure and, consequently, death. Therefore,…”
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11
Optimization of spider silk sphere formation processing conditions to obtain carriers with controlled characteristics
Published in Journal of biomedical materials research. Part A (01-12-2018)“…Bioengineered spider silk is a focus of research due to its biocompatibility, biodegradability, and excellent mechanical properties. Functionalized silk can be…”
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Weak Hypotensive Effect of Chronic Administration of the Dual FAAH/MAGL Inhibitor JZL195 in Spontaneously Hypertensive Rats as Revealed by Area under the Curve Analysis
Published in International journal of molecular sciences (30-06-2023)“…The enhancement of the endocannabinoid tone might have a beneficial influence on hypertension. Polypharmacology proposes multi-target-directed ligands (MTDLs)…”
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13
Cannabidiol Ameliorates Monocrotaline-Induced Pulmonary Hypertension in Rats
Published in International journal of molecular sciences (01-10-2020)“…Cannabidiol (CBD) is known for its vasorelaxant (including in the human pulmonary artery), anti-proliferative and anti-inflammatory properties. The aim of our…”
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14
Cannabidiol may prevent the development of congestive hepatopathy secondary to right ventricular hypertrophy associated with pulmonary hypertension in rats
Published in Pharmacological reports (01-04-2024)“…Pulmonary hypertension (PH) can cause right ventricular (RV) failure and subsequent cardiohepatic syndrome referred to as congestive hepatopathy (CH). Passive…”
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Beneficial Changes in Rat Vascular Endocannabinoid System in Primary Hypertension and under Treatment with Chronic Inhibition of Fatty Acid Amide Hydrolase by URB597
Published in International journal of molecular sciences (02-05-2021)“…Our study aimed to examine the effects of hypertension and the chronic administration of the fatty acid amide hydrolase (FAAH) inhibitor URB597 on vascular…”
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16
GPR18-Mediated Relaxation of Human Isolated Pulmonary Arteries
Published in International journal of molecular sciences (26-01-2022)“…GPR18 receptor protein was detected in the heart and vasculature and appears to play a functional role in the cardiovascular system. We investigated the…”
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17
Implementation of a dynamic culture condition to the heterotypic 3D breast cancer model
Published in Journal of biomedical materials research. Part B, Applied biomaterials (01-05-2020)“…Cell culture system is used for a wide range of research and biotechnology production. Majority of in vitro cell studies are conducted as static, two…”
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Vasoprotective Endothelial Effects of Chronic Cannabidiol Treatment and Its Influence on the Endocannabinoid System in Rats with Primary and Secondary Hypertension
Published in Pharmaceuticals (Basel, Switzerland) (31-10-2021)“…Our study aimed to examine the endothelium (vascular)-protecting effects of chronic cannabidiol (CBD) administration (10 mg/kg once daily for 2 weeks) in…”
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Engineered spider silk: the intelligent biomaterial of the future. Part II
Published in Postȩpy higieny i medycyny doświadczalnej (17-06-2011)“…The development and progress in engineered spider silk manufacturing has enabled its practical application. Recombinant spider silk can assemble in several…”
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Engineered spider silk: the intelligent biomaterial of the future. Part I
Published in Postȩpy higieny i medycyny doświadczalnej (17-06-2011)“…The unique properties of spider silk such as strength, extensibility, toughness, biocompatibility and biodegradability are the reasons for the recent…”
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