Search Results - "Hanna, Courtney W."

Mechanisms of early placental development in mouse and humans by Hemberger, Myriam, Hanna, Courtney W., Dean, Wendy

“…The importance of the placenta in supporting mammalian development has long been recognized, but our knowledge of the molecular, genetic and epigenetic…”
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Placental imprinting: Emerging mechanisms and functions by Hanna, Courtney W

“…As the maternal-foetal interface, the placenta is essential for the establishment and progression of healthy pregnancy, regulating both foetal growth and…”
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Features and mechanisms of canonical and noncanonical genomic imprinting by Hanna, Courtney W, Kelsey, Gavin

“…Genomic imprinting is the monoallelic expression of a gene based on parent of origin and is a consequence of differential epigenetic marking between the male…”
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Multi-omics profiling of mouse gastrulation at single-cell resolution by Argelaguet, Ricard, Clark, Stephen J., Mohammed, Hisham, Stapel, L. Carine, Krueger, Christel, Kapourani, Chantriolnt-Andreas, Imaz-Rosshandler, Ivan, Lohoff, Tim, Xiang, Yunlong, Hanna, Courtney W., Smallwood, Sebastien, Ibarra-Soria, Ximena, Buettner, Florian, Sanguinetti, Guido, Xie, Wei, Krueger, Felix, Göttgens, Berthold, Rugg-Gunn, Peter J., Kelsey, Gavin, Dean, Wendy, Nichols, Jennifer, Stegle, Oliver, Marioni, John C., Reik, Wolf

“…Formation of the three primary germ layers during gastrulation is an essential step in the establishment of the vertebrate body plan and is associated with…”
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A DNMT3A PWWP mutation leads to methylation of bivalent chromatin and growth retardation in mice by Sendžikaitė, Gintarė, Hanna, Courtney W., Stewart-Morgan, Kathleen R., Ivanova, Elena, Kelsey, Gavin

“…DNA methyltransferases (DNMTs) deposit DNA methylation, which regulates gene expression and is essential for mammalian development. Histone post-translational…”
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Genomic imprinting beyond DNA methylation: a role for maternal histones by Hanna, Courtney W, Kelsey, Gavin

“…Inheritance of DNA methylation states from gametes determines genomic imprinting in mammals. A new study shows that repressive chromatin in oocytes can also…”
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Mechanisms and function of de novo DNA methylation in placental development reveals an essential role for DNMT3B by Andrews, Simon, Krueger, Christel, Mellado-Lopez, Maravillas, Hemberger, Myriam, Dean, Wendy, Perez-Garcia, Vicente, Hanna, Courtney W.

“…DNA methylation is a repressive epigenetic modification that is essential for development, exemplified by the embryonic and perinatal lethality observed in…”
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Endogenous retroviral insertions drive non-canonical imprinting in extra-embryonic tissues by Hanna, Courtney W, Pérez-Palacios, Raquel, Gahurova, Lenka, Schubert, Michael, Krueger, Felix, Biggins, Laura, Andrews, Simon, Colomé-Tatché, Maria, Bourc'his, Deborah, Dean, Wendy, Kelsey, Gavin

“…Genomic imprinting is an epigenetic phenomenon that allows a subset of genes to be expressed mono-allelically based on the parent of origin and is typically…”
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Pervasive polymorphic imprinted methylation in the human placenta by Hanna, Courtney W, Peñaherrera, Maria S, Saadeh, Heba, Andrews, Simon, McFadden, Deborah E, Kelsey, Gavin, Robinson, Wendy P

“…The maternal and paternal copies of the genome are both required for mammalian development, and this is primarily due to imprinted genes, those that are…”
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Primitive haematopoiesis in the human placenta gives rise to macrophages with epigenetically silenced HLA-DR by Thomas, Jake R., Appios, Anna, Calderbank, Emily F., Yoshida, Nagisa, Zhao, Xiaohui, Hamilton, Russell S., Moffett, Ashley, Sharkey, Andrew, Laurenti, Elisa, Hanna, Courtney W., McGovern, Naomi

“…The earliest macrophages are generated during embryonic development from erythro-myeloid progenitors (EMPs) via primitive haematopoiesis. Although this process…”
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DNA Methylation Profiling of Placental Villi from Karyotypically Normal Miscarriage and Recurrent Miscarriage by Hanna, Courtney W, McFadden, Deborah E, Robinson, Wendy P

“…Miscarriage occurs in 15% of clinical pregnancies. Although chromosomal errors are observed in >50%, causes of karyotypically normal losses are poorly…”
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Number of Children and Telomere Length in Women: A Prospective, Longitudinal Evaluation by Barha, Cindy K, Hanna, Courtney W, Salvante, Katrina G, Wilson, Samantha L, Robinson, Wendy P, Altman, Rachel M, Nepomnaschy, Pablo A

“…Life history theory (LHT) predicts a trade-off between reproductive effort and the pace of biological aging. Energy invested in reproduction is not available…”
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Epigenetic regulation in development: is the mouse a good model for the human? by Hanna, Courtney W, Demond, Hannah, Kelsey, Gavin

“…Abstract BACKGROUND Over the past few years, advances in molecular technologies have allowed unprecedented mapping of epigenetic modifications in gametes and…”
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No evidence for association of MTHFR 677C>T and 1298A>C variants with placental DNA methylation by Del Gobbo, Giulia F, Price, E Magda, Hanna, Courtney W, Robinson, Wendy P

“…5,10-Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in one-carbon metabolism that ensures the availability of methyl groups for methylation…”
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Loss of DNA methylation disrupts syncytiotrophoblast development: Proposed consequences of aberrant germline gene activation by Lea, Georgia, Hanna, Courtney W.

“…DNA methylation is a repressive epigenetic modification that is essential for development and its disruption is widely implicated in disease. Yet, remarkably,…”
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Child mortality, hypothalamic-pituitary-adrenal axis activity and cellular aging in mothers by Barha, Cindy K, Salvante, Katrina G, Hanna, Courtney W, Wilson, Samantha L, Robinson, Wendy P, Altman, Rachel M, Nepomnaschy, Pablo A

“…Psychological challenges, including traumatic events, have been hypothesized to increase the age-related pace of biological aging. Here we test the hypothesis…”
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Estrogen receptor α gene polymorphisms are associated with idiopathic premature ovarian failure by Bretherick, Karla L., B.Sc, Hanna, Courtney W., B.Sc, Currie, Lauren M., B.Sc, Fluker, Margo R., M.D, Hammond, Geoffrey L., Ph.D, Robinson, Wendy P., Ph.D

“…Objective To assess the role of hormone receptor/binding protein variants in genetic predisposition to premature ovarian failure (POF). Design Case-control…”
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MLL2 conveys transcription-independent H3K4 trimethylation in oocytes by Hanna, Courtney W., Taudt, Aaron, Huang, Jiahao, Gahurova, Lenka, Kranz, Andrea, Andrews, Simon, Dean, Wendy, Stewart, A. Francis, Colomé-Tatché, Maria, Kelsey, Gavin

“…Histone 3 K4 trimethylation (depositing H3K4me3 marks) is typically associated with active promoters yet paradoxically occurs at untranscribed domains…”
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Sex-specific chromatin remodelling safeguards transcription in germ cells by Huang, Tien-Chi, Wang, Yi-Fang, Vazquez-Ferrer, Eric, Theofel, Ina, Requena, Cristina E., Hanna, Courtney W., Kelsey, Gavin, Hajkova, Petra

“…Stability of the epigenetic landscape underpins maintenance of the cell-type-specific transcriptional profile. As one of the main repressive epigenetic…”
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Increased transcriptome variation and localised DNA methylation changes in oocytes from aged mice revealed by parallel single‐cell analysis by Castillo‐Fernandez, Juan, Herrera‐Puerta, Erika, Demond, Hannah, Clark, Stephen J., Hanna, Courtney W., Hemberger, Myriam, Kelsey, Gavin

“…Advancing maternal age causes a progressive reduction in fertility. The decline in developmental competence of the oocyte with age is likely to be a…”
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