Search Results - "Hann, Christopher E"
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A physiological Intensive Control Insulin-Nutrition-Glucose (ICING) model validated in critically ill patients
Published in Computer methods and programs in biomedicine (01-05-2011)“…Abstract Intensive insulin therapy (IIT) and tight glycaemic control (TGC), particularly in intensive care unit (ICU), are the subjects of increasing and…”
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Integral-based parameter identification for long-term dynamic verification of a glucose–insulin system model
Published in Computer methods and programs in biomedicine (01-03-2005)“…Hyperglycaemia in critically ill patients increases the risk of further complications and mortality. This paper introduces a model capable of capturing the…”
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Beat-to-beat estimation of the continuous left and right cardiac elastance from metrics commonly available in clinical settings
Published in Biomedical engineering online (21-09-2012)“…Functional time-varying cardiac elastances (FTVE) contain a rich amount of information about the specific cardiac state of a patient. However, a FTVE waveform…”
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Algorithmic processing of pressure waveforms to facilitate estimation of cardiac elastance
Published in Biomedical engineering online (15-06-2012)“…Cardiac elastances are highly invasive to measure directly, but are clinically useful due to the amount of information embedded in them. Information about the…”
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Integral-based filtering of continuous glucose sensor measurements for glycaemic control in critical care
Published in Computer methods and programs in biomedicine (01-06-2006)“…Hyperglycaemia is prevalent in critical illness and increases the risk of further complications and mortality, while tight control can reduce mortality up to…”
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Model-based insulin sensitivity as a sepsis diagnostic in critical care
Published in Journal of diabetes science and technology (01-05-2008)“…Timely diagnosis and treatment of sepsis in critical care require significant clinical effort, experience, and resources. Insulin sensitivity is known to…”
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Measuring facial grimacing for quantifying patient agitation in critical care
Published in Computer methods and programs in biomedicine (01-08-2007)“…Abstract The effective delivery of sedation in critical care relies primarily on an accurate and consistent measure of a patient's agitation level. However,…”
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Cardiac output estimation using pulmonary mechanics in mechanically ventilated patients
Published in Biomedical engineering online (25-11-2010)“…The application of positive end expiratory pressure (PEEP) in mechanically ventilated (MV) patients with acute respiratory distress syndrome (ARDS) decreases…”
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A three-compartment model of the C-peptide–insulin dynamic during the DIST test
Published in Mathematical biosciences (01-12-2010)“…Dynamic insulin sensitivity ( SI) tests often utilise model-based parameter estimation. This research analyses the impact of expanding the typically used…”
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Tight glycemic control in critical care – The leading role of insulin sensitivity and patient variability: A review and model-based analysis
Published in Computer methods and programs in biomedicine (01-05-2011)“…Abstract Tight glycemic control (TGC) has emerged as a major research focus in critical care due to its potential to simultaneously reduce both mortality and…”
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Stochastic modelling of insulin sensitivity and adaptive glycemic control for critical care
Published in Computer methods and programs in biomedicine (01-02-2008)“…Abstract Targeted, tight model-based glycemic control in critical care patients that can reduce mortality 18–45% is enabled by prediction of insulin…”
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In silico simulation of long-term type 1 diabetes glycemic control treatment outcomes
Published in Journal of diabetes science and technology (01-05-2008)“…The goals of this study were to develop (1) a safe and effective protocol for the clinical control of type 1 diabetes using conventional self-monitoring blood…”
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A minimal model of lung mechanics and model-based markers for optimizing ventilator treatment in ARDS patients
Published in Computer methods and programs in biomedicine (01-08-2009)“…Abstract A majority of patients admitted to the Intensive Care Unit (ICU) require some form of respiratory support. In the case of Acute Respiratory Distress…”
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The impact of parameter identification methods on drug therapy control in an intensive care unit
Published in The open medical informatics journal (2008)“…This paper investigates the impact of fast parameter identification methods, which do not require any forward simulations, on model-based glucose control,…”
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Minimal Models to Capture the Dynamics of a Rotary Unmanned Aerial Vehicle
Published in Journal of intelligent & robotic systems (01-09-2014)“…This paper presents a method for characterising the primary dynamics of a rotary unmanned aerial vehicle. Based on first principles and basic aerodynamics, a…”
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Validation of subject-specific cardiovascular system models from porcine measurements
Published in Computer methods and programs in biomedicine (01-02-2013)“…Abstract A previously validated mathematical model of the cardiovascular system (CVS) is made subject-specific using an iterative, proportional gain-based…”
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A simple insulin-nutrition protocol for tight glycemic control in critical illness: development and protocol comparison
Published in Diabetes technology & therapeutics (01-04-2006)“…Hyperglycemia is prevalent in critical care, and tight control can significantly reduce mortality. However, current protocols have been considered taxing to…”
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A pilot study of the SPRINT protocol for tight glycemic control in critically Ill patients
Published in Diabetes technology & therapeutics (01-08-2006)“…Stress-induced hyperglycemia is prevalent in critical care, even in patients with no history of diabetes. Increased counter-regulatory hormone response…”
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Design and clinical pilot testing of the model-based dynamic insulin sensitivity and secretion test (DISST)
Published in Journal of diabetes science and technology (01-11-2010)“…Insulin resistance is a significant risk factor in the pathogenesis of type 2 diabetes. This article presents pilot study results of the dynamic insulin…”
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Identification of Relaxation Functions in Glass by Mean of a Simple Experiment
Published in Journal of the American Ceramic Society (01-09-2007)“…This communication discusses the possibility of identifying the shear and structure relaxation functions in inorganic glass by means of a single, simple, and…”
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