Search Results - "Hann, C.L"

Epigenetic Analysis of Small Cell Lung Cancer Defines Distinct Disease Subsets by Rudin, C.M, Connis, N, Hann, C.L, Poirier, J.T

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A Prospective Study of FDG-PET Imaging in Assessment of Response to Therapy in Patients with Relapsed or Refractory Non-Hodgkin's Lymphoma Undergoing Salvage Chemotherapy and Autologous Stem Cell Transplant by Hann, C.L, Sussman, J

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DNA methylation in small cell lung cancer defines distinct disease subtypes and correlates with high expression of EZH2 by Poirier, J T, Gardner, E E, Connis, N, Moreira, A L, de Stanchina, E, Hann, C L, Rudin, C M

“…Small cell lung cancer (SCLC) is an aggressive malignancy characterized by early metastasis, rapid development of resistance to chemotherapy and genetic…”
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Investigating the Role of TNIK in the Pathogenesis of Lung Squamous Cell Carcinoma by Chang, J.H., Chowdhury, D.D., Council, D.N., Nguyen, T., Jagtap, S., Chan, A., Khan, M. Ajmal, Connis, N., Torres-Ayuso, P., Brognard, J., Rezaee, M., Lafargue, A., Hann, C.L., Tran, P.T.

“…Lung squamous cell carcinoma (LSCC) is the second most prevalent type of lung cancer with no FDA-approved targeted therapies. Platinum-based chemotherapy and…”
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Impact of TWIST1 Transactivation Domain towards Oncogene-Induced Senescence Suppression in Non-Small Cell Lung Cancer by Lafargue, A., Wang, H., Thiruganasambandam, S., Gajula, R.P., Shetty, A.C., Song, Y., Simons, B.W., Nguyen, T., Connis, N., Chowdhury, D.D., Chang, J.H., Council, D.N., Taparra, K., Rezaee, M., Zachara, N., Morris, Z., McFarland, C., Abdulkadir, S.A., Hann, C.L., Tran, P.T.

“…Non-small cell lung carcinoma (NSCLC) is a major cause of cancer mortality. High expression of the epithelial-to-mesenchymal transition transcription factor…”
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1550TiP Phase II, multicenter, randomized, open-label study of DS-7300 in patients (pts) with pre-treated extensive-stage small cell lung cancer (ES-SCLC) by Paz-Ares, L., Johnson, M.L., Girard, N., Hann, C.L., Ahn, M-J., Nishio, M., Godard, J., Laadem, A., Yoshizuka, N., Qian, M., Cheng, B., Rudin, C.M.

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Epigenetic Analysis of Small Cell Lung Cancer Defines Distinct Disease Subsets: Small Cell Lung Cancer by Rudin, C.M., Connis, N., Hann, C.L., Poirier, J.T.

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Preliminary safety and efficacy of rovalpituzumab tesirine in patients with delta-like protein 3-expressing advanced solid tumors by Aggarwal, R., Mansfield, A., Beltran, H., Farago, A.F., Hann, C.L., Kaye, F., Lewis, K., Niu, J., Richey, S., Smith, D., Soares, H.P., Spira, A., Taylor, M., Waqar, S.N., Lally, S., Rossi, M., Saunders, L., Dylla, S.J., Kavalerchik, E., Anthony, L.

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Clinical features and outcomes of advanced HER2+ esophageal/GEJ cancer with brain metastasis by Liang, K, Feliciano, J L, Marrone, K A, Murray, J C, Hann, C L, Anagnostou, V, Tackett, S A, Shin, E J, Hales, R K, Voong, K R, Battafarano, R J, Yang, S C, Broderick, S R, Ha, J S, Forde, P M, Brahmer, J R, Lam, V K

“…Brain metastasis (BRM) is uncommon in gastroesophageal cancer. As such, clinicopathologic and molecular determinants of BRM and impact on clinical outcome…”
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1543TiP - Phase I/II Study to Assess the Safety, Pharmacokinetics (PK) and Efficacy of Lorvotuzumab Mertansine (LM, IMGN901) in Combination with Carboplatin/Etoposide in Patients with Solid Tumors Including Small-Cell Lung Cancer (SCLC) by Spigel, D.R., Bendell, J., Mita, A.C., Argiris, A., Kurkjian, C., Hann, C.L., Segota, Z., Guild, R., Mastico, R., Guiterrez, M.E.

“…SCLC expresses CD56 almost universally. LM is a CD56-targeting antibody-drug conjugate. This study was initiated to evaluate LM for the treatment of SCLC when…”
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Phase I/II Study to Assess the Safety, Pharmacokinetics (PK) and Efficacy of Lorvotuzumab Mertansine (LM, IMGN901) in Combination with Carboplatin/Etoposide in Patients with Solid Tumors Including Small-Cell Lung Cancer (SCLC) by Spigel, D.R., Bendell, J., Mita, A.C., Argiris, A., Kurkjian, C., Hann, C.L., Segota, Z., Guild, R., Mastico, R., Guiterrez, M.E.

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Intragenic Suppressors of Mutant DNA Topoisomerase I-induced Lethality Diminish Enzyme Binding of DNA by Hann, Christine L., Carlberg, Alyssa L., Bjornsti, Mary-Ann

“…Eukaryotic DNA topoisomerase I (Top1p) catalyzes changes in DNA topology and is the cellular target of the antitumor drug camptothecin (Cpt). Mutation of…”
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Recovery of respiratory ciliary function after depression by inhalation anaesthetic agents: an in vitro study using nasal turbinate explants by Raphael, J H, Strupish, J, Selwyn, D A, Hann, H C, Langton, J A

“…We have developed a human tissue preparation suitable for measurement of cilia beat frequency derived from nasal turbinates. Cilia beat frequency of turbinate…”
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An investigation into the effects of midazolam and propofol on human respiratory cilia beat frequency in vitro by HANN, H. C. L, HALL, A. P, RAPHAEL, J. H, LANGTON, J. A

“…Patients in intensive care are known to be prone to both upper and lower respiratory tract infection. Respiratory mucus forms a barrier to infection. Mucus…”
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