Search Results - "Hanlon, Eugene B."

Three Dimensional Human Neuro-Spheroid Model of Alzheimer's Disease Based on Differentiated Induced Pluripotent Stem Cells by Lee, Han-Kyu, Velazquez Sanchez, Clara, Chen, Mei, Morin, Peter J, Wells, John M, Hanlon, Eugene B, Xia, Weiming

“…The testing of candidate drugs to slow progression of Alzheimer's disease (AD) requires clinical trials that are lengthy and expensive. Efforts to model the…”
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Optical Taxonomic Signal and the Diagnosis of Alzheimer's Disease by Greco, Frank A., Schell, Brent R., Hanlon, Eugene B.

“…Goal: We previously demonstrated that near-infrared spectroscopy in vivo presents spectral features at 895 and 861 nm that accurately classify Alzheimer's…”
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Confocal light absorption and scattering spectroscopic microscopy monitors organelles in live cells with no exogenous labels by Itzkan, Irving, Qiu, Le, Fang, Hui, Zaman, Munir M, Vitkin, Edward, Ghiran, Ionita C, Salahuddin, Saira, Modell, Mark, Andersson, Charlotte, Kimerer, Lauren M, Cipolloni, Patsy B, Lim, Kee-Hak, Freedman, Steven D, Bigio, Irving, Sachs, Benjamin P, Hanlon, Eugene B, Perelman, Lev T

“…This article reports the development of an optical imaging technique, confocal light absorption and scattering spectroscopic (CLASS) microscopy, capable of…”
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Induced pluripotent stem cells (iPSCs) derived from frontotemporal dementia patient's peripheral blood mononuclear cells by Lee, Han-Kyu, Morin, Peter, Wells, John, Hanlon, Eugene B., Xia, Weiming

“…Peripheral blood mononuclear cells (PBMC) were donated by a patient with clinically diagnosed frontotemporal dementia (FTD). Induced pluripotent stem cells…”
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Diagnosis of Gulf War Illness Using Laser-Induced Spectra Acquired from Blood Samples by Gaudiuso, Rosalba, Chen, Sirui, Kokkotou, Efi, Conboy, Lisa, Jacobson, Eric, Hanlon, Eugene B., Melikechi, Noureddine

“…Gulf War illness (GWI) is a chronic illness with no known validated biomarkers that affects the lives of hundreds of thousands of people. As a result, there is…”
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Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett's esophagus by Perelman, Lev T, Qiu, Le, Pleskow, Douglas K, Chuttani, Ram, Vitkin, Edward, Leyden, Jan, Ozden, Nuri, Itani, Sara, Guo, Lianyu, Sacks, Alana, Goldsmith, Jeffrey D, Modell, Mark D, Hanlon, Eugene B, Itzkan, Irving

“…Most cases of esophageal cancer can be prevented if detected early at the precancerous high-grade dysplasia stage in patients presenting with Barrett's…”
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Photon diffusion near the point-of-entry in anisotropically scattering turbid media by Vitkin, Edward, Turzhitsky, Vladimir, Qiu, Le, Guo, Lianyu, Itzkan, Irving, Hanlon, Eugene B., Perelman, Lev T.

“…From astronomy to cell biology, the manner in which light propagates in turbid media has been of central importance for many decades. However, light…”
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Spectral Imaging With Scattered Light: From Early Cancer Detection to Cell Biology by Le Qiu, Turzhitsky, V., Chuttani, R., Pleskow, D. K., Goldsmith, J. D., Lianyu Guo, Vitkin, E., Itzkan, I., Hanlon, E. B., Perelman, L. T.

“…This paper reports the evolution of scanning spectral imaging techniques using scattered light for minimally invasive detection of early cancerous changes in…”
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Confocal light absorption and scattering spectroscopic microscopy by Fang, Hui, Qiu, Le, Vitkin, Edward, Zaman, Munir M, Andersson, Charlotte, Salahuddin, Saira, Kimerer, Lauren M, Cipolloni, Patsy B, Modell, Mark D, Turner, Bradley S, Keates, Sarah E, Bigio, Irving, Itzkan, Irving, Freedman, Steven D, Bansil, Rama, Hanlon, Eugene B, Perelman, Lev T

“…We have developed a novel optical method for observing submicrometer intracellular structures in living cells, which is called confocal light absorption and…”
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Gold nanorod light scattering labels for biomedical imaging by Qiu, Le, Larson, Timothy A, Vitkin, Edward, Guo, Lianyu, Hanlon, Eugene B, Itzkan, Irving, Sokolov, Konstantin V, Perelman, Lev T

“…Gold nanorods can be used as extremely bright labels for differential light scattering measurements using two closely spaced wavelengths, thereby detecting…”
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The Zα Domain of the Editing Enzyme dsRNA Adenosine Deaminase Binds Left-Handed Z-RNA as Well as Z-DNA by Brown, Bernard A., Lowenhaupt, Ky, Wilbert, Christina M., Hanlon, Eugene B., Rich, Alexander

“…The Zα domain of human double-stranded RNA adenosine deaminase 1 binds specifically to left-handed Z-DNA and stabilizes the Z-conformation. Here we report…”
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Scattering differentiates Alzheimer disease in vitro by Hanlon, Eugene B, Perelman, Lev T, Vitkin, Eduard I, Greco, Frank A, McKee, Ann C, Kowall, Neil W

“…The molecular bases of Alzheimer disease and related neurodegenerative disorders are becoming better understood, but the means for definitive diagnosis and…”
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Light-scattering spectroscopy differentiates fetal from adult nucleated red blood cells: may lead to noninvasive prenatal diagnosis by Lim, Kee-Hak, Salahuddin, Saira, Qiu, Le, Fang, Hui, Vitkin, Edward, Ghiran, Ionita C, Modell, Mark D, Takoudes, Tamara, Itzkan, Irving, Hanlon, Eugene B, Sachs, Benjamin P, Perelman, Lev T

“…Present techniques for prenatal diagnosis are invasive and present significant risks of fetal loss. Noninvasive prenatal diagnosis utilizing fetal nucleated…”
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A Comparison of the Environment of Thiol Groups in Bovine and Human γ Crystallins Using Raman Spectroscopy by Pande, Jayanti, Hanlon, Eugene B., Pande, Ajay

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Near-infrared Fluorescence Spectroscopy Detects Alzheimer's Disease In Vitro by Hanlon, Eugene B., Itzkan, Irving, Dasari, Ramachandra R., Feld, Michael S., Ferrante, Robert J., McKee, Ann C., Lathi, Devayani, Kowall, Neil W.

“… The purpose of this study was to investigate whether near‐infrared (NIR) fluorescence spectroscopy could be used to detect Alzheimer's disease (AD) by brain…”
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Observation of plasmon line broadening in single gold nanorods by Qiu, Le, Larson, Timothy A., Smith, Danielle, Vitkin, Edward, Modell, Mark D., Korgel, Brian A., Sokolov, Konstantin V., Hanlon, Eugene B., Itzkan, Irving, Perelman, Lev T.

“…Attempts to realize the important potential of gold nanorods as extremely bright molecular markers have been limited by the broad spectroscopic linewidths…”
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Diagnostic imaging of esophageal epithelium with clinical endoscopic polarized scanning spectroscopy instrument by Le Qiu, Chuttani, R., Songhua Zhang, Jun Feng, Itani, S., Hui Fang, Pleskow, D., Sawhney, M.S., Salahuddin, S., Modell, M.D., Vitkin, E., Hanlon, E.B., Itzkan, I., Perelman, L.T.

“…This letter reports the development of an endoscopic polarized scanning spectroscopy (EPSS) instrument compatible with existing endoscopes. This instrument…”
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Single Gold Nanorod Detection Using Confocal Light Absorption and Scattering Spectroscopy by Le Qiu, Larson, T.A., Smith, D.K., Vitkin, E., Songhua Zhang, Modell, M.D., Itzkan, I., Hanlon, E.B., Korgel, B.A., Sokolov, K.V., Perelman, L.T.

“…Gold nanorods have the potential to be employed as extremely bright molecular marker labels for fluorescence, absorption, or scattering imaging of living…”
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Noninvasive sizing of subcellular organelles with light scattering spectroscopy by Hui Fang, Ollero, M., Vitkin, E., Kimerer, L.M., Cipolloni, P.B., Zaman, M.M., Freedman, S.D., Bigio, I.J., Itzkan, I., Hanlon, E.B., Perelman, L.T.

“…A long-standing impediment for applications of optical techniques in cellular biology is the inability to characterize subcellular structures whose dimensions…”
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Near-infrared Fluorescence Spectroscopy Detects Alzheimer’s Disease In Vitro by Hanlon, Eugene B., Itzkan, Irving, Dasari, Ramachandra R., Feld, Michael S., Ferrante, Robert J., McKee, Ann C., Lathi, Devayani, Kowall, Neil W.

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