Search Results - "Hanley, William"

The Port Delivery System with Ranibizumab for Neovascular Age-Related Macular Degeneration: Results from the Randomized Phase 2 Ladder Clinical Trial by Campochiaro, Peter A, Marcus, Dennis M, Awh, Carl C, Regillo, Carl, Adamis, Anthony P, Bantseev, Vladimir, Chiang, Yawen, Ehrlich, Jason S, Erickson, Signe, Hanley, William D, Horvath, Joshua, Maass, Katie F, Singh, Natasha, Tang, Fan, Barteselli, Giulio

“…To evaluate the safety and efficacy of the Port Delivery System with ranibizumab (PDS) for neovascular age-related macular degeneration (nAMD) treatment. Phase…”
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SYSTEMIC PHARMACOKINETICS AND PHARMACODYNAMICS OF INTRAVITREAL AFLIBERCEPT, BEVACIZUMAB, AND RANIBIZUMAB by Avery, Robert L, Castellarin, Alessandro A, Steinle, Nathan C, Dhoot, Dilsher S, Pieramici, Dante J, See, Robert, Couvillion, Stephen, Nasir, Maʼan A, Rabena, Melvin D, Maia, Mauricio, Van Everen, Sherri, Le, Kha, Hanley, William D

“…To evaluate the systemic pharmacokinetics (PKs) of aflibercept, bevacizumab, and ranibizumab in patients with neovascular age-related macular degeneration…”
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Clinical Pharmacology of the Antibody–Drug Conjugate Enfortumab Vedotin in Advanced Urothelial Carcinoma and Other Malignant Solid Tumors by Tang, Mei, Garg, Amit, Bonate, Peter L., Rosenberg, Jonathan E., Matsangou, Maria, Kadokura, Takeshi, Yamada, Akihiro, Choules, Mary, Pavese, Janet, Nagata, Masanori, Tenmizu, Daisuke, Koibuchi, Akira, Heo, Nakyo, Wang, Lu, Wojtkowski, Tomasz, Hanley, William D., Poondru, Srinivasu

“…Enfortumab vedotin is an antibody–drug conjugate comprised of a human monoclonal antibody directed to Nectin-4 and monomethyl auristatin E (MMAE), a…”
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Exposure-safety and exposure-efficacy analyses for tisotumab vedotin for patients with locally advanced or metastatic solid tumors by Passey, Chaitali, Voellinger, Jenna, Gibiansky, Leonid, Gunawan, Rudy, Nicacio, Leonardo, Soumaoro, Ibrahima, Hanley, William D, Winter, Helen, Gupta, Manish

“…The antibody-drug conjugate (ADC) tisotumab vedotin (TV) received accelerated approval from the US Food and Drug Administration for treatment of adults with…”
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Can untreated PKU patients escape from intellectual disability? A systematic review by van Vliet, Danique, van Wegberg, Annemiek M J, Ahring, Kirsten, Bik-Multanowski, Miroslaw, Blau, Nenad, Bulut, Fatma D, Casas, Kari, Didycz, Bozena, Djordjevic, Maja, Federico, Antonio, Feillet, François, Gizewska, Maria, Gramer, Gwendolyn, Hertecant, Jozef L, Hollak, Carla E M, Jørgensen, Jens V, Karall, Daniela, Landau, Yuval, Leuzzi, Vincenzo, Mathisen, Per, Moseley, Kathryn, Mungan, Neslihan Ö, Nardecchia, Francesca, Õunap, Katrin, Powell, Kimberly K, Ramachandran, Radha, Rutsch, Frank, Setoodeh, Aria, Stojiljkovic, Maja, Trefz, Fritz K, Usurelu, Natalia, Wilson, Callum, van Karnebeek, Clara D, Hanley, William B, van Spronsen, Francjan J

“…Phenylketonuria (PKU) is often considered as the classical example of a genetic disorder in which severe symptoms can nowadays successfully be prevented by…”
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Phase II Study of the Dual EGFR/HER3 Inhibitor Duligotuzumab (MEHD7945A) versus Cetuximab in Combination with FOLFIRI in Second-Line RAS Wild-Type Metastatic Colorectal Cancer by Hill, Andrew G, Findlay, Michael P, Burge, Matthew E, Jackson, Christopher, Alfonso, Pilar Garcia, Samuel, Leslie, Ganju, Vinod, Karthaus, Meinolf, Amatu, Alessio, Jeffery, Mark, Bartolomeo, Maria Di, Bridgewater, John, Coveler, Andrew L, Hidalgo, Manuel, Kapp, Amy V, Sufan, Roxana I, McCall, Bruce B, Hanley, William D, Penuel, Elicia M, Pirzkall, Andrea, Tabernero, Josep

“…Duligotuzumab is a dual-action antibody directed against EGFR and HER3. Metastatic colorectal cancer (mCRC) patients with ex2 wild-type received duligotuzumab…”
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Population pharmacokinetic analysis for tisotumab vedotin in patients with locally advanced and/or metastatic solid tumors by Gibiansky, Leonid, Passey, Chaitali, Voellinger, Jenna, Gunawan, Rudy, Hanley, William D., Gupta, Manish, Winter, Helen

“…Tisotumab vedotin is an investigational antibody–drug conjugate (ADC) for treatment of solid tumors expressing tissue factor with accelerated approval from the…”
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Pharmacokinetics of MHAA4549A, an Anti-Influenza A Monoclonal Antibody, in Healthy Subjects Challenged with Influenza A Virus in a Phase IIa Randomized Trial by Deng, Rong, Lee, Ai Ping, Maia, Mauricio, Lim, Jeremy J., Burgess, Tracy, Horn, Priscilla, Derby, Michael A., Newton, Elizabeth, Tavel, Jorge A., Hanley, William D.

“…Background and Objectives MHAA4549A, a human anti-influenza immunoglobulin (Ig) G1 monoclonal antibody, is being developed to treat patients hospitalized for…”
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Randomized Phase II Study of Duligotuzumab (MEHD7945A) vs. Cetuximab in Squamous Cell Carcinoma of the Head and Neck (MEHGAN Study) by Fayette, Jérôme, Wirth, Lori, Oprean, Cristina, Udrea, Anghel, Jimeno, Antonio, Rischin, Danny, Nutting, Christopher, Harari, Paul M, Csoszi, Tibor, Cernea, Dana, O'Brien, Paul, Hanley, William D, Kapp, Amy V, Anderson, Maria, Penuel, Elicia, McCall, Bruce, Pirzkall, Andrea, Vermorken, Jan B

“…Duligotuzumab, a novel dual-action humanized IgG1 antibody that blocks ligand binding to epidermal growth factor receptor (EGFR) and human epidermal growth…”
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A Bayesian hierarchical method for multiple-event seismic location by Myers, Stephen C., Johannesson, Gardar, Hanley, William

“…We formulate the multiple-event seismic location problem as a Bayesian hierarchical statistical model (BAYHLoc). This statistical model has three distinct…”
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Effect of Rifampin, a Potent Inducer of Drug-Metabolizing Enzymes, on the Pharmacokinetics of Raltegravir by WENNING, Larissa A, HANLEY, William D, STONE, Julie A, GOTTESDIENER, Keith M, WAGNER, John A, IWAMOTO, Marian, BRAINARD, Diana M, PETRY, Amelia S, GHOSH, Kalyan, BO JIN, MANGIN, Eric, MARBURY, Thomas C, BERG, Jolene K, CHODAKEWITZ, Jeffrey A

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Optimal serum phenylalanine for adult patients with phenylketonuria (PKU) by Hanley, William B.

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A Phase I Pharmacokinetic and Pharmacodynamic Study of Dalotuzumab (MK-0646), an Anti-Insulin-like Growth Factor-1 Receptor Monoclonal Antibody, in Patients with Advanced Solid Tumors by ATZORI, Francesco, TABERNERO, Josep, DI COSIMO, Serena, BROWN, Holly, CLARK, Jason, HARDWICK, James S, BECKMAN, Robert A, HANLEY, William D, HSU, Karl, CALVO, Emiliano, ROSELLO, Susana, LANGDON, Ronald B, CERVANTES, Andrés, BASELGA, José, PRUDKIN, Ludmila, ANDREU, Jordi, RODRIGUEZ-BRAUN, Edith, DOMINGO, Amparo, GUIJARRO, Jorge, GAMEZ, Cristina, RODON, Jordi

“…Insulin-like growth factor-1 receptor (IGF-1R) mediates cellular processes in cancer and has been proposed as a therapeutic target. Dalotuzumab (MK-0646) is a…”
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Pharmacokinetics and Exposure-Response Analysis of RG7667, a Combination of Two Anticytomegalovirus Monoclonal Antibodies, in a Phase 2a Randomized Trial To Prevent Cytomegalovirus Infection in High-Risk Kidney Transplant Recipients by Deng, Rong, Wang, Yehong, Maia, Mauricio, Burgess, Tracy, McBride, Jacqueline M, Liao, X Charlene, Tavel, Jorge A, Hanley, William D

“…RG7667, a novel combination of two anticytomegalovirus (anti-CMV) monoclonal IgG1 antibodies (MCMV5322A and MCMV3068A), was designed to block CMV entry into…”
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Pharmacokinetics of the Monoclonal Antibody MHAA4549A Administered in Combination With Oseltamivir in Patients Hospitalized With Severe Influenza A Infection by Deng, Rong, She, Gaohong, Maia, Mauricio, Lim, Jeremy J., Peck, Melicent C., McBride, Jacqueline M., Kulkarni, Priya, Horn, Priscilla, Castro, Aide, Newton, Elizabeth, Tavel, Jorge A., Hanley, William D.

“…MHAA4549A is a human anti‐influenza A monoclonal antibody developed to treat influenza A. We report MHAA4549A serum, nasopharyngeal, and tracheal aspirate…”
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Pharmacokinetic Interactions between the Hepatitis C Virus Inhibitors Elbasvir and Grazoprevir and HIV Protease Inhibitors Ritonavir, Atazanavir, Lopinavir, and Darunavir in Healthy Volunteers by Feng, Hwa-Ping, Caro, Luzelena, Fandozzi, Christine, Chu, Xiaoyan, Guo, Zifang, Talaty, Jennifer, Panebianco, Deborah, Dunnington, Katherine, Du, Lihong, Hanley, William D, Fraser, Iain P, Mitselos, Anna, Denef, Jean-Francois, De Lepeleire, Inge, de Hoon, Jan N, Vandermeulen, Corinne, Marshall, William L, Jumes, Patricia, Huang, Xiaobi, Martinho, Monika, Valesky, Robert, Butterton, Joan R, Iwamoto, Marian, Yeh, Wendy W

“…The combination of the hepatitis C virus (HCV) nonstructural protein 5A (NS5A) inhibitor elbasvir and the NS3/4A protease inhibitor grazoprevir is a potent,…”
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A mechanistic pharmacokinetic/pharmacodynamic model of factor D inhibition in cynomolgus monkeys by lampalizumab for the treatment of geographic atrophy by Le, Kha N, Gibiansky, Leonid, Good, Jeremy, Davancaze, Teresa, van Lookeren Campagne, Menno, Loyet, Kelly M, Morimoto, Alyssa, Jin, Jin, Damico-Beyer, Lisa A, Hanley, William D

“…Lampalizumab is an antigen-binding fragment of a humanized monoclonal antibody against complement factor D (CFD), a rate-limiting enzyme in the activation and…”
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Untreated PKU Patients without Intellectual Disability: What Do They Teach Us? by van Vliet, Danique, van Wegberg, Annemiek M J, Ahring, Kirsten, Bik-Multanowski, Miroslaw, Casas, Kari, Didycz, Bozena, Djordjevic, Maja, Hertecant, Jozef L, Leuzzi, Vincenzo, Mathisen, Per, Nardecchia, Francesca, Powell, Kimberly K, Rutsch, Frank, Stojiljkovic, Maja, Trefz, Fritz K, Usurelu, Natalia, Wilson, Callum, van Karnebeek, Clara D, Hanley, William B, van Spronsen, Francjan J

“…Phenylketonuria (PKU) management is aimed at preventing neurocognitive and psychosocial dysfunction by keeping plasma phenylalanine concentrations within the…”
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The Utility of a Population Approach in Drug–Drug Interaction Assessments: A Simulation Evaluation by Wang, Diane D., Yu, Yanke, Kassir, Nastya, Zhu, Min, Hanley, William D., Earp, Justin C., Chow, Andrew T., Gupta, Manish, Hu, Chuanpu

“…This study aims at evaluating the utility of the population pharmacokinetics approach in therapeutic protein drug‐drug‐interaction (DDI) assessment…”
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CD44 on LS174T colon carcinoma cells possesses E-selectin ligand activity by HANLEY, William D, BURDICK, Monica M, KONSTANTOPOULOS, Konstantinos, SACKSTEIN, Robert

“…Metastasis of circulating tumor cells requires a multistep cascade of events initiated by adhesion of tumor cells to the vascular endothelium of involved…”
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