Search Results - "Hanks, Steven"

Focal adhesion kinase modulates cell adhesion strengthening via integrin activation by Michael, Kristin E, Dumbauld, David W, Burns, Kellie L, Hanks, Steven K, García, Andrés J

“…Focal adhesion kinase (FAK) is an essential nonreceptor tyrosine kinase regulating cell migration, adhesive signaling, and mechanosensing. Using FAK-null cells…”
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A new paradigm for regulation of protein phosphatase 2A function via Src and Fyn kinase–mediated tyrosine phosphorylation by Sontag, Jean-Marie, Schuhmacher, Diana, Taleski, Goce, Jordan, Anthony, Khan, Sarah, Hoffman, Alexander, Gomez, Rey J., Mazalouskas, Matthew D., Hanks, Steven K., Spiller, Benjamin W., Sontag, Estelle, Wadzinski, Brian E.

“…Protein phosphatase 2A (PP2A) is a major phospho-Ser/Thr phosphatase and a key regulator of cellular signal transduction pathways. While PP2A dysfunction has…”
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The signaling and biological implications of FAK overexpression in cancer by Siesser, Priscila M F, Hanks, Steven K

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P130Cas Src-binding and substrate domains have distinct roles in sustaining focal adhesion disassembly and promoting cell migration by Meenderink, Leslie M, Ryzhova, Larisa M, Donato, Dominique M, Gochberg, Daniel F, Kaverina, Irina, Hanks, Steven K

“…The docking protein p130Cas is a prominent Src substrate found in focal adhesions (FAs) and is implicated in regulating critical aspects of cell motility…”
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Crk1/2-dependent signaling is necessary for podocyte foot process spreading in mouse models of glomerular disease by George, Britta, Verma, Rakesh, Soofi, Abdulsalam A, Garg, Puneet, Zhang, Jidong, Park, Tae-Ju, Giardino, Laura, Ryzhova, Larisa, Johnstone, Duncan B, Wong, Hetty, Nihalani, Deepak, Salant, David J, Hanks, Steven K, Curran, Tom, Rastaldi, Maria Pia, Holzman, Lawrence B

“…The morphology of healthy podocyte foot processes is necessary for maintaining the characteristics of the kidney filtration barrier. In most forms of…”
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Structural and functional insights into the interaction between the Cas family scaffolding protein p130Cas and the focal adhesion-associated protein paxillin by Zhang, Chi, Miller, Darcie J., Guibao, Cristina D., Donato, Dominique M., Hanks, Steven K., Zheng, Jie J.

“…The Cas family scaffolding protein p130Cas is a Src substrate localized in focal adhesions (FAs) and functions in integrin signaling to promote cell motility,…”
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Podosome dynamics and location in vascular smooth muscle cells require CLASP-dependent microtubule bending by Zhu, Xiaodong, Efimova, Nadia, Arnette, Christopher, Hanks, Steven K., Kaverina, Irina

“…Extracellular matrix (ECM) remodeling during physiological processes is mediated by invasive protrusions called podosomes. Positioning and dynamics of…”
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Global phosphotyrosine proteomics identifies PKCδ as a marker of responsiveness to Src inhibition in colorectal cancer by McKinley, Eliot T, Liu, Huiling, McDonald, W Hayes, Luo, Weifeng, Zhao, Ping, Coffey, Robert J, Hanks, Steven K, Manning, H Charles

“…Sensitive and specific biomarkers of protein kinase inhibition can be leveraged to accelerate drug development studies in oncology by associating early…”
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ARHGAP42 is activated by Src-mediated tyrosine phosphorylation to promote cell motility by Luo, Weifeng, Janoštiak, Radoslav, Tolde, Ondřej, Ryzhova, Larisa M, Koudelková, Lenka, Dibus, Michal, Brábek, Jan, Hanks, Steven K, Rosel, Daniel

“…The tyrosine kinase Src acts as a key regulator of cell motility by phosphorylating multiple protein substrates that control cytoskeletal and adhesion…”
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Roles Played by a Subset of Integrin Signaling Molecules in Cadherin-Based Cell-Cell Adhesion by Yano, Hajime, Mazaki, Yuichi, Kurokawa, Kazuo, Hanks, Steven K., Matsuda, Michiyuki, Sabe, Hisataka

“…Integrins can intercommunicate with cadherins. Here, we examined their possible relationship by use of small interfering RNA-mediated protein knockdown in HeLa…”
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Dynamics and Mechanism of p130Cas Localization to Focal Adhesions by Donato, Dominique M., Ryzhova, Larisa M., Meenderink, Leslie M., Kaverina, Irina, Hanks, Steven K.

“…The docking protein p130Cas is a major Src substrate involved in integrin signaling and mechanotransduction. Tyrosine phosphorylation of p130Cas in focal…”
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Absolute Quantification of Phosphorylation on the Kinase Activation Loop of Cellular Focal Adhesion Kinase by Stable Isotope Dilution Liquid Chromatography/Mass Spectrometry by Ciccimaro, Eugene, Hanks, Steven K, Yu, Kenneth H, Blair, Ian A

“…A vital point of convergence for many signaling pathways at cellular focal adhesions is the interaction of two nonreceptor tyrosine kinases, focal adhesion…”
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Focal Adhesion Kinase is Involved in Mechanosensing during Fibroblast Migration by Wang, Hong-Bei, Dembo, Micah, Hanks, Steven K., Wang, Yu-li

“…Focal adhesion kinase (FAK) is a non-receptor protein tyrosine kinase localized at focal adhesions and is believed to mediate adhesion-stimulated effects…”
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Tyrosine phosphorylation within the SH3 domain regulates CAS subcellular localization, cell migration, and invasiveness by Janoštiak, Radoslav, Tolde, Ondřej, Brůhová, Zuzana, Novotný, Marian, Hanks, Steven K, Rösel, Daniel, Brábek, Jan

“…Crk-associated substrate (CAS) is a major tyrosine-phosphorylated protein in cells transformed by v-crk and v-src oncogenes and plays an important role in…”
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Global Impact of Oncogenic Src on a Phosphotyrosine Proteome by Luo, Weifeng, Slebos, Robbert J, Hill, Salisha, Li, Ming, Brábek, Jan, Amanchy, Ramars, Chaerkady, Raghothama, Pandey, Akhilesh, Ham, Amy-Joan L, Hanks, Steven K

“…Elevated activity of Src, the first characterized protein-tyrosine kinase, is associated with progression of many human cancers, and Src has attracted interest…”
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Genomic analysis of the eukaryotic protein kinase superfamily: a perspective by Hanks, Steven K

“…Protein kinases with a conserved catalytic domain make up one of the largest 'superfamilies' of eukaryotic proteins and play many key roles in biology and…”
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Regulation of FAK Ser-722 phosphorylation and kinase activity by GSK3 and PP1 during cell spreading and migration by Bianchi, Mariarita, De Lucchini, Stefania, Marin, Oriano, Turner, David L, Hanks, Steven K, Villa-Moruzzi, Emma

“…In addition to tyrosine sites, FAK (focal adhesion kinase) is phosphorylated on multiple serine residues. In the present study, the regulation of two of these…”
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Cellular Responses to Substrate Topography: Role of Myosin II and Focal Adhesion Kinase by Frey, Margo T., Tsai, Irene Y., Russell, Thomas P., Hanks, Steven K., Wang, Yu-li

“…Although two-dimensional cultures have been used extensively in cell biological research, most cells in vivo exist in a three-dimensional environment with…”
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Focal Adhesion Kinase Suppresses Apoptosis by Binding to the Death Domain of Receptor-Interacting Protein by Kurenova, Elena, Xu, Li-Hui, Yang, Xihui, Baldwin, Albert S., Craven, Rolf J., Hanks, Steven K., Liu, Zheng-gang, Cance, William G.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Focal Adhesion Kinase Is Activated and Mediates the Early Hypertrophic Response to Stretch in Cardiac Myocytes by Torsoni, Adriana S, Constancio, Sabata S, Nadruz, Wilson, Hanks, Steven K, Franchini, Kleber G

“…Previously we reported that the rapid activation of the Fak/Src multicomponent signaling complex mediates load-induced activation of growth and survival…”
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