Search Results - "Hankenson, Kurt"

GAGE: generally applicable gene set enrichment for pathway analysis by Luo, Weijun, Friedman, Michael S, Shedden, Kerby, Hankenson, Kurt D, Woolf, Peter J

“…Gene set analysis (GSA) is a widely used strategy for gene expression data analysis based on pathway knowledge. GSA focuses on sets of related genes and has…”
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Integration of BMP, Wnt, and notch signaling pathways in osteoblast differentiation by Lin, Grace L., Hankenson, Kurt D.

“…Bone marrow‐derived mesenchymal stem cells (MSCs) are multipotent progenitors that can commit to osteoblast, chondrocyte, adipocyte, and several other…”
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Cellular biology of fracture healing by Bahney, Chelsea S., Zondervan, Robert L., Allison, Patrick, Theologis, Alekos, Ashley, Jason W., Ahn, Jaimo, Miclau, Theodore, Marcucio, Ralph S., Hankenson, Kurt D.

“…ABSTRACT The biology of bone healing is a rapidly developing science. Advances in transgenic and gene‐targeted mice have enabled tissue and cell‐specific…”
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Extracellular matrix networks in bone remodeling by Alford, Andrea I., Kozloff, Kenneth M., Hankenson, Kurt D.

“…Bones are constantly remodeled throughout life to maintain robust structure and function. Dysfunctional remodeling can result in pathological conditions such…”
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Angiogenesis in bone regeneration by Hankenson, Kurt D, Dishowitz, Michael, Gray, Chancellor, Schenker, Mara

“…Abstract Angiogenesis is a key component of bone repair. New blood vessels bring oxygen and nutrients to the highly metabolically active regenerating callus…”
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Thrombospondins modulate cell function and tissue structure in the skeleton by Alford, Andrea I, Hankenson, Kurt D

“…Thrombospondins (TSPs) belong to a functional class of ECM proteins called matricellular proteins that are not primarily structural, but instead influence…”
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Deficiency of the pattern-recognition receptor CD14 protects against joint pathology and functional decline in a murine model of osteoarthritis by Sambamurthy, Nisha, Zhou, Cheng, Nguyen, Vu, Smalley, Ryan, Hankenson, Kurt D, Dodge, George R, Scanzello, Carla R

“…CD14 is a monocyte/macrophage pattern-recognition receptor that modulates innate inflammatory signaling. Soluble CD14 levels in knee OA synovial fluids are…”
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A PDGFRβ-PI3K signaling axis mediates periosteal cell activation during fracture healing by Doherty, Laura, Yu, Jungeun, Wang, Xi, Hankenson, Kurt D, Kalajzic, Ivo, Sanjay, Archana

“…Insufficient and delayed fracture healing remain significant public health problems with limited therapeutic options. Phosphoinositide 3-kinase (PI3K)…”
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Genome-scale Capture C promoter interactions implicate effector genes at GWAS loci for bone mineral density by Chesi, Alessandra, Wagley, Yadav, Johnson, Matthew E., Manduchi, Elisabetta, Su, Chun, Lu, Sumei, Leonard, Michelle E., Hodge, Kenyaita M., Pippin, James A., Hankenson, Kurt D., Wells, Andrew D., Grant, Struan F. A.

“…Osteoporosis is a devastating disease with an essential genetic component. GWAS have discovered genetic signals robustly associated with bone mineral density…”
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Notch Signaling Promotes Osteoclast Maturation and Resorptive Activity by Ashley, Jason W., Ahn, Jaimo, Hankenson, Kurt D.

“…ABSTRACT The role of Notch signaling in osteoclast differentiation is controversial with conflicting experimental evidence indicating both stimulatory and…”
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Lipolysis of bone marrow adipocytes is required to fuel bone and the marrow niche during energy deficits by Li, Ziru, Bowers, Emily, Zhu, Junxiong, Yu, Hui, Hardij, Julie, Bagchi, Devika P, Mori, Hiroyuki, Lewis, Kenneth T, Granger, Katrina, Schill, Rebecca L, Romanelli, Steven M, Abrishami, Simin, Hankenson, Kurt D, Singer, Kanakadurga, Rosen, Clifford J, MacDougald, Ormond A

“…To investigate roles for bone marrow adipocyte (BMAd) lipolysis in bone homeostasis, we created a BMAd-specific Cre mouse model in which we knocked out adipose…”
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Signaling pathways associated with Lgr6 to regulate osteogenesis by King, Justin S., Wan, Matthew, Wagley, Yadav, Stestiv, Marta, Kalajzic, Ivo, Hankenson, Kurt D., Sanjay, Archana

“…Fracture management largely relies on the bone's inherent healing capabilities and, when necessary, surgical intervention. Currently, there are limited…”
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Synovial fibroblasts assume distinct functional identities and secrete R-spondin 2 in osteoarthritis by Knights, Alexander J, Farrell, Easton C, Ellis, Olivia M, Lammlin, Lindsey, Junginger, Lucas M, Rzeczycki, Phillip M, Bergman, Rachel F, Pervez, Rida, Cruz, Monique, Knight, Eleanor, Farmer, Dennis, Samani, Alexa A, Wu, Chia-Lung, Hankenson, Kurt D, Maerz, Tristan

“…Synovium is acutely affected following joint trauma and contributes to post-traumatic osteoarthritis (PTOA) progression. Little is known about discrete cell…”
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Immunomodulation by mesenchymal stem cells combats the foreign body response to cell-laden synthetic hydrogels by Swartzlander, Mark D, Blakney, Anna K, Amer, Luke D, Hankenson, Kurt D, Kyriakides, Themis R, Bryant, Stephanie J

“…Abstract The implantation of non-biological materials, including scaffolds for tissue engineering, ubiquitously leads to a foreign body response (FBR). We…”
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Wnt-associated adult stem cell marker Lgr6 is required for osteogenesis and fracture healing by Doherty, Laura, Wan, Matthew, Peterson, Anna, Youngstrom, Daniel W., King, Justin S., Kalajzic, Ivo, Hankenson, Kurt D., Sanjay, Archana

“…Despite the remarkable regenerative capacity of skeletal tissues, nonunion of bone and failure of fractures to heal properly presents a significant clinical…”
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Temporal dynamics of immune-stromal cell interactions in fracture healing by Capobianco, Christina A, Hankenson, Kurt D, Knights, Alexander J

“…Bone fracture repair is a complex, multi-step process that involves communication between immune and stromal cells to coordinate the repair and regeneration of…”
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An anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, biomacromolecules, and nanoparticles by Evans, Brian C., Fletcher, R. Brock, Kilchrist, Kameron V., Dailing, Eric A., Mukalel, Alvin J., Colazo, Juan M., Oliver, Matthew, Cheung-Flynn, Joyce, Brophy, Colleen M., Tierney, John W., Isenberg, Jeffrey S., Hankenson, Kurt D., Ghimire, Kedar, Lander, Cynthia, Gersbach, Charles A., Duvall, Craig L.

“…Peptides and biologics provide unique opportunities to modulate intracellular targets not druggable by conventional small molecules. Most peptides and…”
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An Intact Periosteum is Required for Recombinant Human Jagged1 Guided Bone Regeneration in Calvaria Critical-size Defect Healing by Senos, Rafael, Chen, Matheus Ton Yan, Panse, Isabella, Stella, Jose Joaquin, Hankenson, Kurt D

“…The need to promote calvaria bone healing as a consequence of injury or craniotomy is a major clinical issue. Previous reports tested recombinant human Jagged1…”
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Modulation of Notch1 signaling regulates bone fracture healing by Novak, Sanja, Roeder, Emilie, Sinder, Benjamin P., Adams, Douglas J., Siebel, Chris W., Grcevic, Danka, Hankenson, Kurt D., Matthews, Brya G., Kalajzic, Ivo

“…Fracture healing involves interactions of different cell types, driven by various growth factors, and signaling cascades. Periosteal mesenchymal progenitor…”
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Wnt Signaling Stimulates Osteoblastogenesis of Mesenchymal Precursors by Suppressing CCAAT/Enhancer-binding Protein α and Peroxisome Proliferator-activated Receptor γ by Kang, Sona, Bennett, Christina N., Gerin, Isabelle, Rapp, Lauren A., Hankenson, Kurt D., MacDougald, Ormond A.

“…Mesenchymal precursor cells have the potential to differentiate into several cell types, including adipocytes and osteoblasts. Activation of Wnt/β-catenin…”
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