Search Results - "Hanke, Mark"

Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential by Hanke, Mark L, Kielian, Tammy

“…The discovery of mammalian TLRs (Toll-like receptors), first identified in 1997 based on their homology with Drosophila Toll, greatly altered our understanding…”
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Toll-like receptor (TLR) and inflammasome actions in the central nervous system by Hanamsagar, Richa, Hanke, Mark L, Kielian, Tammy

“…During the past 10 years, much attention has been focused towards elucidating the impact of Toll-like receptors (TLRs) in central nervous system (CNS) innate…”
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Neutrophils dominate the immune cell composition in non-small cell lung cancer by Kargl, Julia, Busch, Stephanie E., Yang, Grace H. Y., Kim, Kyoung-Hee, Hanke, Mark L., Metz, Heather E., Hubbard, Jesse J., Lee, Sylvia M., Madtes, David K., McIntosh, Martin W., Houghton, A. McGarry

“…The response rate to immune checkpoint inhibitor therapy for non-small-cell lung cancer (NSCLC) is just 20%. To improve this figure, several early phase…”
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MyD88-dependent signaling influences fibrosis and alternative macrophage activation during Staphylococcus aureus biofilm infection by Hanke, Mark L, Angle, Amanda, Kielian, Tammy

“…Bacterial biofilms represent a significant therapeutic challenge based on their ability to evade host immune and antibiotic-mediated clearance. Recent studies…”
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Lung Cancer Subtypes Generate Unique Immune Responses by Busch, Stephanie E, Hanke, Mark L, Kargl, Julia, Metz, Heather E, MacPherson, David, Houghton, A McGarry

“…Lung cancer, the leading cause of cancer-related deaths worldwide, is a heterogeneous disease comprising multiple histologic subtypes that harbor disparate…”
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Deciphering mechanisms of staphylococcal biofilm evasion of host immunity by Hanke, Mark L, Kielian, Tammy

“…Biofilms are adherent communities of bacteria contained within a complex matrix. Although host immune responses to planktonic staphylococcal species have been…”
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Staphylococcus aureus biofilms prevent macrophage phagocytosis and attenuate inflammation in vivo by Thurlow, Lance R, Hanke, Mark L, Fritz, Teresa, Angle, Amanda, Aldrich, Amy, Williams, Stetson H, Engebretsen, Ian L, Bayles, Kenneth W, Horswill, Alexander R, Kielian, Tammy

“…Biofilms are complex communities of bacteria encased in a matrix composed primarily of polysaccharides, extracellular DNA, and protein. Staphylococcus aureus…”
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β-Adrenergic receptor antagonism prevents anxiety-like behavior and microglial reactivity induced by repeated social defeat by Wohleb, Eric S, Hanke, Mark L, Corona, Angela W, Powell, Nicole D, Stiner, La'Tonia M, Bailey, Michael T, Nelson, Randy J, Godbout, Jonathan P, Sheridan, John F

“…Psychosocial stress is associated with altered immune function and development of psychological disorders including anxiety and depression. Here we show that…”
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Targeting macrophage activation for the prevention and treatment of Staphylococcus aureus biofilm infections by Hanke, Mark L, Heim, Cortney E, Angle, Amanda, Sanderson, Sam D, Kielian, Tammy

“…Biofilm infections often lead to significant morbidity due to their chronicity and recalcitrance to antibiotics. We have demonstrated that…”
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CcpA regulates arginine biosynthesis in Staphylococcus aureus through repression of proline catabolism by Nuxoll, Austin S, Halouska, Steven M, Sadykov, Marat R, Hanke, Mark L, Bayles, Kenneth W, Kielian, Tammy, Powers, Robert, Fey, Paul D

“…Staphylococcus aureus is a leading cause of community-associated and nosocomial infections. Imperative to the success of S. aureus is the ability to adapt and…”
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Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia by Henry, Christopher J, Huang, Yan, Wynne, Angela, Hanke, Mark, Himler, Justin, Bailey, Michael T, Sheridan, John F, Godbout, Jonathan P

“…Activation of the peripheral innate immune system stimulates the secretion of CNS cytokines that modulate the behavioral symptoms of sickness. Excessive…”
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Staphylococcus aureus Biofilms Induce Macrophage Dysfunction Through Leukocidin AB and Alpha-Toxin by Scherr, Tyler D, Hanke, Mark L, Huang, Ouwen, James, David B A, Horswill, Alexander R, Bayles, Kenneth W, Fey, Paul D, Torres, Victor J, Kielian, Tammy

“…The macrophage response to planktonic Staphylococcus aureus involves the induction of proinflammatory microbicidal activity. However, S. aureus biofilms can…”
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Transformation of Human Cathelicidin LL-37 into Selective, Stable, and Potent Antimicrobial Compounds by Wang, Guangshun, Hanke, Mark L, Mishra, Biswajit, Lushnikova, Tamara, Heim, Cortney E, Chittezham Thomas, Vinai, Bayles, Kenneth W, Kielian, Tammy

“…This Letter reports a family of novel antimicrobial compounds obtained by combining peptide library screening with structure-based design. Library screening…”
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Database screening and in vivo efficacy of antimicrobial peptides against methicillin-resistant Staphylococcus aureus USA300 by Menousek, Joseph, Mishra, Biswajit, Hanke, Mark L, Heim, Cortney E, Kielian, Tammy, Wang, Guangshun

“…Abstract Natural antimicrobial peptides (AMPs) are promising candidates for developing a generation of new antimicrobials to meet the challenge of…”
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Global Transcriptome Analysis of Staphylococcus aureus Biofilms in Response to Innate Immune Cells by Scherr, Tyler D, Roux, Christelle M, Hanke, Mark L, Angle, Amanda, Dunman, Paul M, Kielian, Tammy

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Treatment with Repository Corticotropin Injection in Patients with Rheumatoid Arthritis, Systemic Lupus Erythematosus, and Dermatomyositis/Polymyositis by Ho-Mahler, Nancy, Turner, Beni, Eaddy, Michael, Hanke, Mark L, Nelson, Winnie W

“…Repository corticotropin injection (RCI) is indicated for a number of autoimmune-mediated diseases including rheumatoid arthritis (RA), systemic lupus…”
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Correction: Targeting Macrophage Activation for the Prevention and Treatment of Staphylococcus aureus Biofilm Infections by Hanke, Mark L., Heim, Cortney E., Angle, Amanda, Sanderson, Sam D., Kielian, Tammy

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Social disruption induces lung inflammation by Curry, Jennifer M, Hanke, Mark L, Piper, Melissa G, Bailey, Michael T, Bringardner, Benjamin D, Sheridan, John F, Marsh, Clay B

“…Abstract Social disruption (SDR) is a well-characterized mouse stressor that causes changes in immune cell reactivity in response to inflammatory stimuli. In…”
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Immunogenic dendritic cells primed by social defeat enhance adaptive immunity to influenza A virus by Powell, Nicole D, Mays, Jacqueline W, Bailey, Michael T, Hanke, Mark L, Sheridan, John F

“…Research highlights ► SDR, a model of social defeat, significantly influences immunogenic DCs. ► Adoptively transferred DCs from SDR mice enhance adaptive…”
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Stress and the anti-influenza immune response: Repeated social defeat augments clonal expansion of CD8+ T cells during primary influenza A viral infection by Mays, Jacqueline W, Powell, Nicole D, Hunzeker, John T, Hanke, Mark L, Bailey, Michael T, Sheridan, John F

“…Abstract Social disruption stress (SDR) prior to primary influenza A virus (IAV) infection augments memory to IAV re-challenge in a T cell-specific manner…”
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