Search Results - "Hani, Zaher"

Long-time Instability and Unbounded Sobolev Orbits for Some Periodic Nonlinear Schrödinger Equations by Hani, Zaher

“…We study the energy cascade problematic for some nonlinear Schrödinger equations on T 2 in terms of the growth of Sobolev norms. We define the notion of…”
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Ribosome quality control antagonizes the activation of the integrated stress response on colliding ribosomes by Yan, Liewei L., Zaher, Hani S.

“…Stalling during translation triggers ribosome quality control (RQC) to maintain proteostasis. Recently, stalling has also been linked to the activation of…”
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How do cells cope with RNA damage and its consequences? by Yan, Liewei L., Zaher, Hani S.

“…Similar to many other biological molecules, RNA is vulnerable to chemical insults from endogenous and exogenous sources. Noxious agents such as reactive oxygen…”
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Ribosome Collision Is Critical for Quality Control during No-Go Decay by Simms, Carrie L., Yan, Liewei L., Zaher, Hani S.

“…No-go decay (NGD) is a eukaryotic quality control mechanism that evolved to cope with translational arrests. The process is characterized by an endonucleolytic…”
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Canary in a coal mine: collided ribosomes as sensors of cellular conditions by Kim, Kyusik Q., Zaher, Hani S.

“…The recent discovery that collision of ribosomes triggers quality control and stress responses in eukaryotes has shifted the perspective of the field. Collided…”
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Fidelity at the Molecular Level: Lessons from Protein Synthesis by Zaher, Hani S., Green, Rachel

“…The faithful and rapid translation of genetic information into peptide sequences is an indispensable property of the ribosome. The mechanistic understanding of…”
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Inhomogeneous turbulence for the Wick Nonlinear Schrödinger equation by Hani, Zaher, Shatah, Jalal, Zhu, Hui

“…We introduce a simplified model for wave turbulence theory—the Wick nonlinear Schrödinger equation, of which the main feature is the absence of all…”
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RNA Damage Responses in Cellular Homeostasis, Genome Stability, and Disease by Zaher, Hani S, Mosammaparast, Nima

“…All cells are exposed to chemicals that can damage their nucleic acids. Cells must protect these polymers because they code for key factors or complexes…”
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Quality control of chemically damaged RNA by Simms, Carrie L., Zaher, Hani S.

“…The “central dogma” of molecular biology describes how information contained in DNA is transformed into RNA and finally into proteins. In order for proteins to…”
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Oxidation and alkylation stresses activate ribosome-quality control by Yan, Liewei L., Simms, Carrie L., McLoughlin, Fionn, Vierstra, Richard D., Zaher, Hani S.

“…Oxidation and alkylation of nucleobases are known to disrupt their base-pairing properties within RNA. It is, however, unclear whether organisms have evolved…”
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An Active Role for the Ribosome in Determining the Fate of Oxidized mRNA by Simms, Carrie L., Hudson, Benjamin H., Mosior, John W., Rangwala, Ali S., Zaher, Hani S.

“…Chemical damage to RNA affects its functional properties and thus may pose a significant hurdle to the translational apparatus; however, the effects of damaged…”
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A Primary Role for Release Factor 3 in Quality Control during Translation Elongation in Escherichia coli by Zaher, Hani S., Green, Rachel

“…Release factor 3 (RF3) is a GTPase found in a broad range of bacteria where it is thought to play a critical “recycling” role in translation by facilitating…”
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Quality control by the ribosome following peptide bond formation by Green, Rachel, Zaher, Hani S

“…The overall fidelity of protein synthesis has been thought to rely on the combined accuracy of two basic processes: the aminoacylation of transfer RNAs with…”
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A short translational ramp determines the efficiency of protein synthesis by Verma, Manasvi, Choi, Junhong, Cottrell, Kyle A., Lavagnino, Zeno, Thomas, Erica N., Pavlovic-Djuranovic, Slavica, Szczesny, Pawel, Piston, David W., Zaher, Hani S., Puglisi, Joseph D., Djuranovic, Sergej

“…Translation initiation is a major rate-limiting step for protein synthesis. However, recent studies strongly suggest that the efficiency of protein synthesis…”
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The weakly nonlinear large-box limit of the 2D cubic nonlinear Schrödinger equation by Faou, Erwan, Germain, Pierre, Hani, Zaher

“…We consider the cubic nonlinear Schrödinger (NLS) equation set on a two-dimensional box of size L with periodic boundary conditions. By taking the large-box…”
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Global Well-Posedness of the Cubic Nonlinear Schrödinger Equation on Closed Manifolds by Hani, Zaher

“…We consider the defocusing cubic non-linear Schrödinger equation on general closed (compact without boundary) Riemannian surfaces. The problem was shown to be…”
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On the derivation of the wave kinetic equation for NLS by Deng, Yu, Hani, Zaher

“…A fundamental question in wave turbulence theory is to understand how the wave kinetic equation describes the long-time dynamics of its associated nonlinear…”
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Translating while under attack: Plant defense mRNAs find a way by Kim, Kyusik Q, Zaher, Hani S

“…In plants, pattern-triggered immunity shuts down global translation while allowing the translation of defense mRNAs. Wang et al. (2022) describe a previously…”
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Hyperaccurate and Error-Prone Ribosomes Exploit Distinct Mechanisms during tRNA Selection by Zaher, Hani S., Green, Rachel

“…Escherichia coli strains displaying hyperaccurate (restrictive) and ribosomal ambiguity (ram) phenotypes have long been associated with alterations in rpsL and…”
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Ribosome‐based quality control of mRNA and nascent peptides by Simms, Carrie L., Thomas, Erica N., Zaher, Hani S.

“…Quality control processes are widespread and play essential roles in detecting defective molecules and removing them in order to maintain organismal fitness…”
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