Search Results - "Haney, Anessa"

A Sex-Dependent, Tropic Role for Leptin in the Somatotrope as a Regulator of POU1F1 and POU1F1-Dependent Hormones by Odle, Angela K, Allensworth-James, Melody L, Akhter, Noor, Syed, Mohsin, Haney, Anessa C, MacNicol, Melanie, MacNicol, Angus M, Childs, Gwen V

“…Pituitary somatotropes perform the key function of coordinating organismic growth and body composition with metabolic signals. However, the mechanism by which…”
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Metabolic signalling to somatotrophs: Transcriptional and post‐transcriptional mediators by Allensworth‐James, Melody L., Odle, Angela K., Lim, Juchan, LaGasse, Alex N., Miles, Tiffany K., Hardy, Linda L., Haney, Anessa C., MacNicol, Melanie C., MacNicol, Angus M., Childs, Gwen V.

“…In normal individuals, pituitary somatotrophs optimise body composition by responding to metabolic signals from leptin. To identify mechanisms behind the…”
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The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs by Banik, Jewel, Moreira, Ana Rita Silva, Lim, Juchan, Tomlinson, Sophia, Hardy, Linda L., Lagasse, Alex, Haney, Anessa, Crimmins, Meghan R., Boehm, Ulrich, Odle, Angela K., MacNicol, Melanie C., Childs, Gwen V., MacNicol, Angus M.

“…The pituitary functions as a master endocrine gland that secretes hormones critical for regulation of a wide variety of physiological processes including…”
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Selective Deletion of Leptin Receptors in Gonadotropes Reveals Activin and GnRH-Binding Sites as Leptin Targets in Support of Fertility by Akhter, Noor, CarlLee, Tyler, Syed, Mohsin M, Odle, Angela K, Cozart, Michael A, Haney, Anessa C, Allensworth-James, Melody L, Beneš, Helen, Childs, Gwen V

“…The adipokine, leptin (LEP), is a hormonal gateway, signaling energy stores to appetite-regulatory neurons, permitting reproduction when stores are sufficient…”
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Sex differences in somatotrope response to fasting: biphasic responses in male mice by Miles, Tiffany K, Silva Moreira, Ana Rita, Allensworth-James, Melody L, Odle, Angela K, Haney, Anessa C, MacNicol, Angus M, MacNicol, Melanie C, Childs, Gwen V

“…Anterior pituitary somatotropes are important metabolic sensors responding to leptin by secreting growth hormone (GH). However, reduced leptin signals caused…”
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Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain by Miles, Tiffany K, Allensworth-James, Melody L, Odle, Angela K, Silva Moreira, Ana Rita, Haney, Anessa C, LaGasse, Alex N, Gies, Allen J, Byrum, Stephanie D, Riojas, Angelica M, MacNicol, Melanie C, MacNicol, Angus M, Childs, Gwen V

“…Maternal nutrition during embryonic development and lactation influences multiple aspects of offspring health. Using mice, this study investigates the effects…”
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MyD88-Dependent Signals Are Essential for the Host Immune Response in Experimental Brain Abscess by Kielian, Tammy, Phulwani, Nirmal K, Esen, Nilufer, Syed, Mohsin Md, Haney, Anessa C, McCastlain, Kelly, Johnson, Jennifer

“…Brain abscesses form in response to a parenchymal infection by pyogenic bacteria, with Staphylococcus aureus representing a common etiologic agent of human…”
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Ghrelin Restoration of Function In Vitro in Somatotropes from Male Mice Lacking the Janus Kinase (JAK)-Binding Site of the Leptin Receptor by Syed, Mohsin, Cozart, Michael, Haney, Anessa C, Akhter, Noor, Odle, Angela K, Allensworth-James, Melody, Crane, Christopher, Syed, Farhan M, Childs, Gwen V

“…Deletion of the signaling domain of leptin receptors selectively in somatotropes, with Cre-loxP technology, reduced the percentage of immunolabeled GH cells…”
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Toll-Like Receptor 2 Modulates the Proinflammatory Milieu in Staphylococcus aureus-Induced Brain Abscess by Kielian, Tammy, Haney, Anessa, Mayes, Patrick M, Garg, Sarita, Esen, Nilufer

“…Toll-like receptor 2 (TLR2) is a pattern recognition receptor (PRR) that plays an important role in innate immune recognition of conserved structural motifs on…”
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410 Mild Maternal Undernutrition Results in a Premature Neonatal Leptin Surge and Resistance in Male Offspring to a High Fat Diet by Miles, Tiffany K., Allensworth, Melody L., Silva Moreira, Ana Rita, Odle, Angela K., Haney, Anessa, Lagasse, Alexandra, MacNicol, Angus M., Childs, Gwen V.

“…OBJECTIVES/GOALS: Maternal undernutrition, a form of malnutrition, can alter neonatal leptin signaling and result in metabolic dysfunction in adulthood. We…”
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Ablation of Leptin Signaling to Somatotropes: Changes in Metabolic Factors that Cause Obesity by Akhter, Noor, Odle, Angela K, Allensworth-James, Melody L, Haney, Anessa C, Syed, Mohsin M, Cozart, Michael A, Chua, Streamson, Kineman, Rhonda, Childs, Gwen V

“…Mice with somatotrope-specific deletion of the Janus kinase binding site in leptin receptors are GH deficient as young adults and become obese by 6 months of…”
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Sex Differences in Somatotrope Dependency on Leptin Receptors in Young Mice: Ablation of LEPR Causes Severe Growth Hormone Deficiency and Abdominal Obesity in Males by Allensworth-James, Melody L, Odle, Angela, Haney, Anessa, Childs, Gwen

“…Leptin receptor (LEPR) signaling controls appetite and energy expenditure. Somatotrope-specific deletion of the LEPRb signaling isoform causes GH deficiency…”
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Adipocyte Versus Pituitary Leptin in the Regulation of Pituitary Hormones: Somatotropes Develop Normally in the Absence of Circulating Leptin by Odle, Angela K, Haney, Anessa, Allensworth-James, Melody, Akhter, Noor, Childs, Gwen V

“…Leptin is a cytokine produced by white fat cells, skeletal muscle, the placenta, and the pituitary gland among other tissues. Best known for its role in…”
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Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism by Miles, Tiffany K, Odle, Angela K, Byrum, Stephanie D, Lagasse, Alex, Haney, Anessa, Ortega, Victoria G, Bolen, Cole R, Banik, Jewel, Reddick, Milla M, Herdman, Ashley, MacNicol, Melanie C, MacNicol, Angus M, Childs, Gwen V

“…Abstract Anterior pituitary cell function requires a high level of protein synthesis and secretion which depend heavily on mitochondrial adenosine triphosphate…”
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Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle by Moreira, Ana Rita Silva, Lim, Juchan, Urbaniak, Alicja, Banik, Jewel, Bronson, Katherine, Lagasse, Alex, Hardy, Linda, Haney, Anessa, Allensworth, Melody, Miles, Tiffany K, Gies, Allen, Byrum, Stephanie D, Wilczynska, Ania, Boehm, Ulrich, Kharas, Michael, Lengner, Christopher, MacNicol, Melanie C, Childs, Gwen V, MacNicol, Angus M, Odle, Angela K

“…Abstract The anterior pituitary controls key biological processes, including growth, metabolism, reproduction, and stress responses through distinct cell types…”
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Somatotrope Responses to Acute and Prolonged Loss of Leptin Signaling by Miles, Tiffany K., Allensworth-James, Melody, Moreira, Ana Rita Silva, Odle, Angela, Haney, Anessa C., Lagasse, Alexandra, MacNicol, Angus, Childs, Gwen V.

“…Abstract only In mice and humans, fasting results in a rise of serum growth hormone (GH). In mice, this coincides with increased Gh and growth hormone…”
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8649 Ablation of Leptin Receptors in Somatotropes Impacts Transcriptomic Plasticity in the Pou1f1 Lineage of Female Pituitary Cells by Miles, Tiffany K, Odle, Angela Katherine, Byrum, Stephanie, Lagasse, Alex, Haney, Anessa, Ortega, Victoria G, Herdman, Ashley, MacNicol, Melanie C, MacNicol, Angus M, Childs, Gwen V

“…Abstract Disclosure: T.K. Miles: None. A.K. Odle: None. S. Byrum: None. A. Lagasse: None. A. Haney: None. V.G. Ortega: None. A. Herdman: None. M.C. MacNicol:…”
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Association of Gnrhr mRNA With the Stem Cell Determinant Musashi: A Mechanism for Leptin-Mediated Modulation of GnRHR Expression by Odle, Angela K, Beneš, Helen, Melgar Castillo, Andrea, Akhter, Noor, Syed, Mohsin, Haney, Anessa, Allensworth-James, Melody, Hardy, Linda, Winter, Benjamin, Manoharan, Ragul, Syed, Raiyan, MacNicol, Melanie C, MacNicol, Angus M, Childs, Gwen V

“…Abstract The cyclic expression of pituitary gonadotropin-releasing hormone receptors (GnRHRs) may be an important checkpoint for leptin regulatory signals…”
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Sex-specific changes in postnatal GH and PRL secretion in somatotrope LEPR-null mice by Allensworth-James, Melody L, Odle, Angela, Haney, Anessa, MacNicol, Melanie, MacNicol, Angus, Childs, Gwen

“…The developing pituitary is a rapidly changing environment that is constantly meeting the physiological demands of the growing organism. During early postnatal…”
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Adipocyte Versus Somatotrope Leptin: Regulation of Metabolic Functions in the Mouse by Odle, Angela Katherine, Allensworth-James, Melody, Haney, Anessa, Akhter, Noor, Syed, Mohsin, Childs, Gwen V

“…Leptin regulates food intake and energy expenditure (EE) and is produced in adipocytes, the pituitary, and several other tissues. Animals that are leptin or…”
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