Search Results - "Hanessian, S."

Catalytic Asymmetric Conjugate Addition of Nitroalkanes to Cycloalkenones by Hanessian, Stephen, Pham, Vinh

“…Nitroalkanes add to cyclic and acyclic enones in an enantioselective manner in the presence of catalytic quantities of l-proline and…”
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Docking of Aminoglycosides to Hydrated and Flexible RNA by Moitessier, Nicolas, Westhof, Eric, Hanessian, Stephen

“…Although much effort has been devoted to the development of programs suited for the docking of ligands to proteins, much less progress has been achieved in the…”
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Phosphorylation of a constrained azacyclic FTY720 analog enhances anti-leukemic activity without inducing S1P receptor activation by McCracken, A N, McMonigle, R J, Tessier, J, Fransson, R, Perryman, M S, Chen, B, Keebaugh, A, Selwan, E, Barr, S A, Kim, S M, Roy, S G, Liu, G, Fallegger, D, Sernissi, L, Brandt, C, Moitessier, N, Snider, A J, Clare, S, Müschen, M, Huwiler, A, Kleinman, M T, Hanessian, S, Edinger, A L

“…The frequency of poor outcomes in relapsed leukemia patients underscores the need for novel therapeutic approaches. The Food and Drug Administration-approved…”
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Synthesis, broad spectrum antibacterial activity, and X-ray co-crystal structure of the decoding bacterial ribosomal A-site with 4′-deoxy-4′-fluoro neomycin analogs by Hanessian, S, Saavedra, OM, Vilchis-Reyes, MA, Maianti, J P, Kanazawa, H, Dozzo, P, Matias, R D, Serio, A, Kondo, J

“…This study reports the synthesis, antibacterial evaluation and nature of fluorine-rRNA contacts revealed by an X-ray co-crystal structure of a series of…”
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Design of Secondary Structures in Unnatural Peptides: Stable Helical γ-Tetra-, Hexa-, and Octapeptides and Consequences of α-Substitution by Hanessian, Stephen, Luo, Xuehong, Schaum, Robert, Michnick, Stephen

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Reflections on the total synthesis of natural products: Art, craft, logic, and the chiron approach by Hanessian, S.

“…Abstract…”
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Bifunctional bis(oxazolines) as potential ligands in catalytic asymmetric reactions by Hanessian, Stephen, Jnoff, Eric, Bernstein, Noemy, Simard, Michel

“…C 2 -symmetrical bis(oxazoline) ligands bearing pendant alkylthio ether groups were synthesized, and the structures of Cu complexes were determined by single…”
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New and old challenges in total synthesis. From concept to practice by Hanessian, S., Margarita, Roberto, Hall, Adrian, Johnstone, Shawn, Tremblay, M., Parlanti, L.

“…The total synthesis of dysinosin A, a novel member of the aeruginosin group of marine natural products is discussed. The stereocontrolled synthesis also…”
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The psychobiological basis of heuristic synthesis planning - man, machine and the chiron approach by Hanessian, S., Franco, Jonathan, Larouche, Benoit

“…Abstract…”
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Heteroatom-assisted substitution of acyclic secondary tosylates with lithium dialkylcuprates. An expedient route to stereochemically defined deoxypropionate and related biosynthetic subunits by Hanessian, S, Thavonekham, B, DeHoff, B

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The synthesis of substituted lactones by intramolecular chirality transfer with stereodifferentiating chiral .alpha.-ester radical intermediates by Hanessian, S, Di Fabio, R, Marcoux, J. F, Prud'homme, M

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trans-1,2-Diaminocyclohexane Derivatives as Chiral Reagents, Scaffolds, and Ligands for Catalysis:  Applications in Asymmetric Synthesis and Molecular Recognition by Bennani, Youssef L, Hanessian, Stephen

“…A look at how some chiral motifs have become the reagents of choice in daily research activities, as well as for the large-scale production of drugs and fine…”
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The N-Acyloxyiminium Ion Aza-Prins Route to Octahydroindoles:  Total Synthesis and Structural Confirmation of the Antithrombotic Marine Natural Product Oscillarin by Hanessian, Stephen, Tremblay, Martin, Petersen, Jens F. W

“…The first enantiocontrolled total synthesis of the marine natural product oscillarin is described. The proposed structure and absolute configuration of…”
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Stereocontrolled Glycosyl Transfer Reactions with Unprotected Glycosyl Donors by Hanessian, Stephen, Lou, Boliang

“…Successful examples of glycoside and oligosaccharide synthesis using O-unprotected glycosyl donors with a 3-methoxy-2-pyridyloxy (MOP) leaving group at the…”
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Synthesis of functionally diverse bicyclic sulfonamides as constrained proline analogues and application to the design of potential thrombin inhibitors by Hanessian, Stephen, Sailes, Helen, Therrien, Eric

“…Bicyclic sulfonamides were synthesized from 4-alkenyl N-alkenylsulfonyl l-prolines using a ring-closure metathesis reaction. Three types of bicyclic…”
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Design and synthesis of conformationally constrained amino acids as versatile scaffolds and peptide mimetics by Hanessian, Stephen, McNaughton-Smith, Grant, Lombart, Henry-Georges, Lubell, William D.

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Progress in natural product chemistry by the chiron and related approaches - synthesis of avermectin B1a by Hanessian, S., Ugolini, A., Hodges, P. J., Beaulieu, Pierre, Dube, Daniel, Andre, Christiane

“…Abstract…”
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Neuronal activity-dependent increase of net matrix metalloproteinase activity is associated with MMP-9 neurotoxicity after kainate by Jourquin, Jérôme, Tremblay, Evelyne, Décanis, Nadège, Charton, Gérard, Hanessian, Stephen, Chollet, Anne-Marie, Le Diguardher, Thierry, Khrestchatisky, Michel, Rivera, Santiago

“…Matrix metalloproteinases (MMPs) and the tissue inhibitors of MMPs (TIMPs) are emerging as important modulators of brain physiopathology. Dramatic changes in…”
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Synthesis, broad spectrum antibacterial activity, and X-ray co-crystal structure of the decoding bacterial ribosomal A-site with 4′-deoxy-4′-fluoro neomycin analogsElectronic supplementary information (ESI) available. See DOI: 10.1039/c4sc01626b by Hanessian, S, Saavedra, O. M, Vilchis-Reyes, M. A, Maianti, J. P, Kanazawa, H, Dozzo, P, Matias, R. D, Serio, A, Kondo, J

“…This study reports the synthesis, antibacterial evaluation and nature of fluorine-rRNA contacts revealed by an X-ray co-crystal structure of a series of…”
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Antibacterial Aminoglycosides with a Modified Mode of Binding to the Ribosomal-RNA Decoding Site by François, Boris, Szychowski, Janek, Adhikari, Susanta Sekhar, Pachamuthu, Kandasamy, Swayze, Eric E., Griffey, Richard H., Migawa, Michael T., Westhof, Eric, Hanessian, Stephen

“…A new twist of RNA fate: Site‐selective chemical functionalization at the C2′′OH group of paromomycin (1) afforded a novel analogue with potent inhibitory…”
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