Search Results - "Hanenberg, H"

Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair by Park, J-Y, Singh, T R, Nassar, N, Zhang, F, Freund, M, Hanenberg, H, Meetei, A R, Andreassen, P R

“…Heterozygous carriers of germ-line mutations in the BRCA2/FANCD1 , PALB2/FANCN and RAD51C/FANCO DNA repair genes have an increased lifetime risk of developing…”
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Evidence for a novel anti-apoptotic pathway in human keratinocytes involving the aryl hydrocarbon receptor, E2F1, and checkpoint kinase 1 by Frauenstein, K, Sydlik, U, Tigges, J, Majora, M, Wiek, C, Hanenberg, H, Abel, J, Esser, C, Fritsche, E, Krutmann, J, Haarmann-Stemmann, T

“…Exposure of keratinocytes (KC) to ultraviolet (UV) radiation results in the initiation of apoptosis, a protective mechanism that eliminates cells harboring…”
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Optimized NGFR-derived hinges for rapid and efficient enrichment and detection of CAR T cells in vitro and in vivo by Bister, A., Ibach, T., Haist, C., Gerhorst, G., Smorra, D., Soldierer, M., Roellecke, K., Wagenmann, M., Scheckenbach, K., Gattermann, N., Wiek, C., Hanenberg, H.

“…Chimeric antigen receptor (CAR) T cell therapy has demonstrated unprecedented success with high remission rates for heavily pretreated patients with…”
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Optimized human CYP4B1 in combination with the alkylator prodrug 4-ipomeanol serves as a novel suicide gene system for adoptive T-cell therapies by Roellecke, K, Virts, E L, Einholz, R, Edson, K Z, Altvater, B, Rossig, C, von Laer, D, Scheckenbach, K, Wagenmann, M, Reinhardt, D, Kramm, C M, Rettie, A E, Wiek, C, Hanenberg, H

“…Engineering autologous or allogeneic T cells to express a suicide gene can control potential toxicity in adoptive T-cell therapies. We recently reported the…”
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Squamous cell carcinomas of the head and neck in Fanconi anemia: risk, prevention, therapy, and the need for guidelines by Scheckenbach, K, Wagenmann, M, Freund, M, Schipper, J, Hanenberg, H

“…Fanconi anemia (FA) is a rare recessive DNA repair disorder that is clinically characterized by congenital malformations, progressive bone marrow failure, and…”
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Assessment of bile salt export pump (BSEP) inhibition by BSEP-reactive immunoglobulins from Antibody-induced BSEP deficiency patients using a novel, cell-based assay by Stindt, J, Dröge, C, Wammers, M, Philippski, P, Wiek, C, Hanenberg, H, Häussinger, D, Keitel, V

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The centrosomal protein TACC3 controls paclitaxel sensitivity by modulating a premature senescence program by Schmidt, S, Schneider, L, Essmann, F, Cirstea, I C, Kuck, F, Kletke, A, Jänicke, R U, Wiek, C, Hanenberg, H, Ahmadian, M R, Schulze-Osthoff, K, Nürnberg, B, Piekorz, R P

“…Microtubule-interfering cancer drugs such as paclitaxel (PTX) often cause chemoresistance and severe side effects, including neurotoxicity. To explore…”
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Shared Genetic Susceptibility to Breast Cancer, Brain Tumors, and Fanconi Anemia by Offit, Kenneth, Levran, Orna, Mullaney, Brian, Mah, Katherine, Nafa, Khedoudja, Batish, Sat Dev, Diotti, Raffaella, Schneider, Hildegard, Deffenbaugh, Amie, Scholl, Thomas, Proud, Virginia K., Robson, Mark, Norton, Larry, Ellis, Nathan, Hanenberg, Helmut, Auerbach, Arleen D.

“…Fanconi anemia is an inherited disease characterized by bone marrow failure, congenital malformations, and predisposition to cancer. The breast cancer…”
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Outcomes of mismatched and unrelated donor hematopoietic stem cell transplantation in Fanconi anemia conditioned with chemotherapy only by Chao, M. M., Kuehl, J. S., Strauss, G., Hanenberg, H., Schindler, D., Neitzel, H., Niemeyer, C., Baumann, I., von Bernuth, H., Rascon, J., Nagy, M., Zimmermann, M., Kratz, C. P., Ebell, W.

“…Fanconi anemia (FA) is a genomic instability syndrome associated with bone marrow failure, myelodysplastic syndrome (MDS), and/or acute myeloid leukemia (AML)…”
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Finnish Fanconi anemia mutations and hereditary predisposition to breast and prostate cancer by Mantere, T., Haanpää, M., Hanenberg, H., Schleutker, J., Kallioniemi, A., Kähkönen, M., Parto, K., Avela, K., Aittomäki, K., von Koskull, H., Hartikainen, J.M., Kosma, V.-M., Laasanen, S.-L., Mannermaa, A., Pylkäs, K., Winqvist, R.

“…Mutations in downstream Fanconi anemia (FA) pathway genes, BRCA2, PALB2, BRIP1 and RAD51C, explain part of the hereditary breast cancer susceptibility, but the…”
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Consensus of German transplant centers on hematopoietic stem cell transplantation in Fanconi anemia by Chao, M M, Ebell, W, Bader, P, Beier, R, Burkhardt, B, Feuchtinger, T, Handgretinger, R, Hanenberg, H, Koehl, U, Kratz, C, Kremens, B, Lang, P, Meisel, R, Mueller, I, Roessig, C, Sauer, M, Schlegel, P G, Schulz, A, Strahm, B, Thol, F, Sykora, K W

“…Allogeneic hematopoietic stem cell transplantation (HSCT) is currently the only curative therapy for the severe hematopoietic complications associated with…”
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Targeted expression of human folylpolyglutamate synthase for selective enhancement of methotrexate chemotherapy in osteosarcoma cells by Bienemann, K, Staege, M S, Howe, S J, Sena-Esteves, M, Hanenberg, H, Kramm, C M

“…The antifolate methotrexate (MTX) is an important chemotherapeutic agent for treatment of osteosarcoma. This drug is converted intracellularly into…”
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Reverse mosaicism in Fanconi anemia: natural gene therapy via molecular self-correction by Gross, M, Hanenberg, H, Lobitz, S, Friedl, R, Herterich, S, Dietrich, R, Gruhn, B, Schindler, D, Hoehn, H

“…Fanconi anemia (FA) is a genetically and phenotypically heterogenous autosomal recessive disease associated with chromosomal instability and hypersensitivity…”
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Significantly increased CD70 up regulation on TEL-AML positive B cell precursor acute lymphoblastic leukemia cells following CD40 stimulation by Troeger, A, Glouchkova, L, Ackermann, B, Escherich, G, Hanenberg, H, Janka, G, Roettgers, S, Göbel, U, Dilloo, D

“…TEL-AML the most common genetic alteration in childhood precursor B acute lymphoblastic leukemia (BCP-ALL) is associated with a favorable prognosis. We studied…”
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Empowering nurses and midwives: the evidence-base for the Nurses and Midwives Certification Programme of ESHRE by Somers, S, Cotton, H, Kendrew, H, Pomper, J, Pinborg, A, Jorgensen, I R, Plas, C, Hanenberg, E H, Peddie, V L, Dancet, E A F

“…Abstract STUDY QUESTION How were the logbook and curriculum for the Nurses and Midwives Certification Programme of ESHRE developed? SUMMARY ANSWER The logbook…”
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Disruption of the FA/BRCA pathway in bladder cancer by Neveling, K, Kalb, R, Florl, A R, Herterich, S, Friedl, R, Hoehn, H, Hader, C, Hartmann, F H, Nanda, I, Steinlein, C, Schmid, M, Tonnies, H, Hurst, C D, Knowles, M A, Hanenberg, H, Schulz, W A, Schindler, D

“…Bladder carcinomas frequently show extensive deletions of chromosomes 9p and/or 9q, potentially including the loci of the Fanconi anemia (FA) genes FANCC and…”
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Transduction of wild-type merlin into human schwannoma cells decreases schwannoma cell growth and induces apoptosis by SCHULZE, K. M. M, HANEMANN, C. O, MÜLLER, H. W, HANENBERG, H

“…Mutations in both alleles of the tumour suppressor gene coding for merlin/schwannomin, an ERM family protein, cause the hereditary disease neurofibromatosis…”
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TACC3 depletion sensitizes to paclitaxel-induced cell death and overrides p21WAF-mediated cell cycle arrest by Schneider, L, Essmann, F, Kletke, A, Rio, P, Hanenberg, H, Schulze-Osthoff, K, Nürnberg, B, Piekorz, R P

“…Regulators of the mitotic spindle apparatus are attractive cellular targets for antitumor therapy. The centrosomal protein transforming acidic coiled coil…”
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A simplified approach to improve the efficiency and safety of ex vivo hematopoietic gene therapy in fanconi anemia patients by Jacome, A, Navarro, S, Casado, J A, Rio, P, Madero, L, Estella, J, Sevilla, J, Badell, I, Ortega, J J, Olivé, T, Hanenberg, H, Segovia, J C, Bueren, J A

“…Fanconi anemia (FA) is an inherited DNA repair disorder characterized by genetic instability of cells lacking a functional FA/BRCA pathway. Previous studies…”
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Selection of novel mediators of E2F1-induced apoptosis through retroviral expression of an antisense cDNA library by Li, Z., Stanelle, J., Leurs, C., Hanenberg, H., Pützer, B. M.

“…The E2F1 transcription factor is an essential mediator of p53-dependent and p53-independent apoptosis as part of an anti-tumour safeguard mechanism. In this…”
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