Search Results - "Hanek, Ariele P"

A Unified View of the Role of Electrostatic Interactions in Modulating the Gating of Cys Loop Receptors by Xiu, Xinan, Hanek, Ariele P., Wang, Jinti, Lester, Henry A., Dougherty, Dennis A.

“…In the Cys loop superfamily of ligand-gated ion channels, a global conformational change, initiated by agonist binding, results in channel opening and the…”
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A Stereochemical Test of a Proposed Structural Feature of the Nicotinic Acetylcholine Receptor by Hanek, Ariele P, Lester, Henry A, Dougherty, Dennis A

“…Understanding the gating mechanism of the nicotinic acetylcholine receptor (nAChR) and similar channels constitutes a significant challenge in chemical…”
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A cation-pi interaction in the binding site of the glycine receptor is mediated by a phenylalanine residue by Pless, Stephan A, Millen, Kat S, Hanek, Ariele P, Lynch, Joseph W, Lester, Henry A, Lummis, Sarah C R, Dougherty, Dennis A

“…Cys-loop receptor binding sites characteristically contain many aromatic amino acids. In nicotinic ACh and 5-HT3 receptors, a Trp residue forms a cation-pi…”
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A cation-π interaction at a phenylalanine residue in the glycine receptor binding site is conserved for different agonists by Pless, Stephan A, Hanek, Ariele P, Price, Kerry L, Lynch, Joseph W, Lester, Henry A, Dougherty, Dennis A, Lummis, Sarah C R

“…Cation-π interactions have been demonstrated to play a major role in agonist-binding in Cys-loop receptors. However, neither the aromatic amino acid…”
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Photochemical proteolysis of an unstructured linker of the GABAAR extracellular domain prevents GABA but not pentobarbital activation by Hanek, Ariele P, Lester, Henry A, Dougherty, Dennis A

“…The GABA type A receptor (GABA(A)R) is the major inhibitory receptor in the mammalian central nervous system and the target of numerous pharmaceuticals. The…”
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Unnatural Amino Acid Mutagenesis of the GABAA Receptor Binding Site Residues Reveals a Novel Cation–π Interaction between GABA and β2Tyr97 by Padgett, Claire L., Hanek, Ariele P., Lester, Henry A., Dougherty, Dennis A., Lummis, Sarah C. R.

“…The binding pockets of Cys-loop receptors are dominated by aromatic amino acids. In the GABA A receptor α 1 Phe65, β 2 Tyr97, β 2 Tyr157, and β 2 Tyr205 are…”
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Unnatural Amino Acid Mutagenesis of the GABA A Receptor Binding Site Residues Reveals a Novel Cation–π Interaction between GABA and β 2 Tyr97 by Padgett, Claire L., Hanek, Ariele P., Lester, Henry A., Dougherty, Dennis A., Lummis, Sarah C. R.

“…The binding pockets of Cys-loop receptors are dominated by aromatic amino acids. In the GABA A receptor α 1 Phe65, β 2 Tyr97, β 2 Tyr157, and β 2 Tyr205 are…”
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Unnatural Amino Acid Mutagenesis of the GABA sub(A) Receptor Binding Site Residues Reveals a Novel Cation- pi Interaction between GABA and {szligbeta} sub(2)Tyr97 by Padgett, Claire L, Hanek, Ariele P, Lester, Henry A, Dougherty, Dennis A, Lummis, Sarah CR

“…The binding pockets of Cys-loop receptors are dominated by aromatic amino acids. In the GABA sub(A) receptor alpha sub(1)Phe65, {szligbeta} sub(2)Tyr97,…”
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Unnatural amino acid mutagenesis of the GABA(A) receptor binding site residues reveals a novel cation-pi interaction between GABA and beta 2Tyr97 by Padgett, Claire L, Hanek, Ariele P, Lester, Henry A, Dougherty, Dennis A, Lummis, Sarah C R

“…The binding pockets of Cys-loop receptors are dominated by aromatic amino acids. In the GABA(A) receptor alpha1Phe65, beta2Tyr97, beta2Tyr157, and beta2Tyr205…”
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Unnatural Amino Acid Mutagenesis of the GABAA Receptor Binding Site Residues Reveals a Novel Cation-{pi} Interaction between GABA and {beta}2Tyr97 by Padgett, Claire L, Hanek, Ariele P, Lester, Henry A, Dougherty, Dennis A, Lummis, Sarah C. R

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A Cation-{pi} Interaction in the Binding Site of the Glycine Receptor Is Mediated by a Phenylalanine Residue by Pless, Stephan A, Millen, Kat S, Hanek, Ariele P, Lynch, Joseph W, Lester, Henry A, Lummis, Sarah C. R, Dougherty, Dennis A

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