Search Results - "Hanein, D"

The rheostat in the membrane: BCL-2 family proteins and apoptosis by Volkmann, N, Marassi, F M, Newmeyer, D D, Hanein, D

“…Apoptosis, a mechanism for programmed cell death, has key roles in human health and disease. Many signals for cellular life and death are regulated by the…”
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Three-dimensional structure of Bax-mediated pores in membrane bilayers by Xu, X-P, Zhai, D, Kim, E, Swift, M, Reed, J C, Volkmann, N, Hanein, D

“…B-cell lymphoma 2 (Bcl-2)-associated X protein (Bax) is a member of the Bcl-2 protein family having a pivotal role in triggering cell commitment to apoptosis…”
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Structure of Arp2/3 Complex in Its Activated State and in Actin Filament Branch Junctions by Volkmann, Niels, Amann, Kurt J., Stoilova-McPhie, Svetla, Egile, Coumaran, Winter, Dirk C., Hazelwood, Larnele, Heuser, John E., Li, Rong, Pollard, Thomas D., Hanein, Dorit

“…The seven-subunit Arp2/3 complex choreographs the formation of branched actin networks at the leading edge of migrating cells. When activated by…”
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An atomic model of fimbrin binding to F-actin and its implications for filament crosslinking and regulation by Hanein, Dorit, Volkmann, Niels, Goldsmith, Sharon, Michon, Anne-Marie, Lehman, William, Craig, Roger, DeRosier, David, Almo, Steve, Matsudaira, Paul

“…Using a new procedure that combines electron-density correlation with biochemical information, we have fitted the crystal structure of the N-terminal…”
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Ena/VASP Proteins Enhance Actin Polymerization in the Presence of Barbed End Capping Proteins by Barzik, Melanie, Kotova, Tatyana I, Higgs, Henry N, Hazelwood, Larnele, Hanein, Dorit, Gertler, Frank B, Schafer, Dorothy A

“…Ena/VASP proteins influence the organization of actin filament networks within lamellipodia and filopodia of migrating cells and in actin comet tails. The…”
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Quantitative Fitting of Atomic Models into Observed Densities Derived by Electron Microscopy by Volkmann, Niels, Hanein, Dorit

“…A new methodology for fitting atomic models into density distributions is described. This approach is based on a global density correlation analysis that can…”
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Three-Dimensional Structure of Vinculin Bound to Actin Filaments by Janssen, Mandy E.W., Kim, Eldar, Liu, Hongjun, Fujimoto, L. Miya, Bobkov, Andrey, Volkmann, Niels, Hanein, Dorit

“…Vinculin plays a pivotal role in cell adhesion and migration by providing the link between the actin cytoskeleton and the transmembrane receptors, integrin and…”
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Docking of atomic models into reconstructions from electron microscopy by Volkmann, Niels, Hanein, Dorit

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An Atomic Model of Actin Filaments Cross-Linked by Fimbrin and Its Implications for Bundle Assembly and Function by Volkmann, Niels, DeRosier, David, Matsudaira, Paul, Hanein, Dorit

“…Actin bundles have profound effects on cellular shape, division, adhesion, motility, and signaling. Fimbrin belongs to a large family of actin-bundling…”
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The Structural Basis of Myosin V Processive Movement as Revealed by Electron Cryomicroscopy by Volkmann, Niels, Liu, HongJun, Hazelwood, Larnele, Krementsova, Elena B., Lowey, Susan, Trybus, Kathleen M., Hanein, Dorit

“…The processive motor myosin V has a relatively high affinity for actin in the presence of ATP and, thus, offers the unique opportunity to visualize some of the…”
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Mechanism of filament nucleation and branch stability revealed by the structure of the Arp2/3 complex at actin branch junctions by Egile, Coumaran, Rouiller, Isabelle, Xu, Xiao-Ping, Volkmann, Niels, Li, Rong, Hanein, Dorit

“…Actin branch junctions are conserved cytoskeletal elements critical for the generation of protrusive force during actin polymerization-driven cellular…”
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Evidence for cleft closure in actomyosin upon ADP release by Hanein, Dorit, Volkmann, Niels, Ouyang, Greta, Trybus, Kathleen M, DeRosier, David J, Lowey, Susan

“…Structural insights into the interaction of smooth muscle myosin with actin have been provided by computer-based fitting of crystal structures into…”
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Characterization of an Actin-binding Site within the Talin FERM Domain by Lee, Ho-Sup, Bellin, Robert M., Walker, Diane L., Patel, Bipin, Powers, Pam, Liu, Hongjun, Garcia-Alvarez, Begoña, de Pereda, José M., Liddington, Robert C., Volkmann, Niels, Hanein, Dorit, Critchley, David R., Robson, Richard M.

“…Talin is a large cytoskeletal protein that couples integrins to F-actin. Three actin-binding sites (ABS1–3) have been reported: one in the N-terminal head, and…”
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Effects of Arp2 and Arp3 nucleotide-binding pocket mutations on Arp2/3 complex function by Martin, Adam C, Xu, Xiao-Ping, Rouiller, Isabelle, Kaksonen, Marko, Sun, Yidi, Belmont, Lisa, Volkmann, Niels, Hanein, Dorit, Welch, Matthew, Drubin, David G

“…Contributions of actin-related proteins (Arp) 2 and 3 nucleotide state to Arp2/3 complex function were tested using nucleotide-binding pocket (NBP) mutants in…”
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Oligomeric Rings of the Sec61p Complex Induced by Ligands Required for Protein Translocation by Hanein, Dorit, Matlack, Kent E.S, Jungnickel, Berit, Plath, Kathrin, Kalies, Kai-Uwe, Miller, Kenneth R, Rapoport, Tom A, Akey, Christopher W

“…The heterotrimeric Sec61p complex is a major component of the protein-conducting channel of the endoplasmic reticulum (ER) membrane, associating with either…”
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Actomyosin: law and order in motility by Volkmann, Niels, Hanein, Dorit

“…The crystal structures of smooth muscle and scallop striated muscle myosin have both been completed in the past 18 months. Structural studies of unconventional…”
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Evidence for a Conformational Change in Actin Induced by Fimbrin (N375) Binding by Hanein, Dorit, Matsudaira, Paul, DeRosier, David J.

“…Fimbrin belongs to a superfamily of actin cross-linking proteins that share a conserved 27-kD actin-binding domain. This domain contains a tandem duplication…”
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Myosin Isoforms Show Unique Conformations in the Actin-Bound State by Volkmann, Niels, Ouyang, Greta, Trybus, Kathleen M., DeRosier, David J., Lowey, Susan, Hanein, Dorit

“…Crystallographic data for several myosin isoforms have provided evidence for at least two conformations in the absence of actin: a prehydrolysis state that is…”
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Differential Adhesion of Cells to Enantiomorphous Crystal Surfaces by Hanein, Dorit, Geiger, Benjamin, Addadi, Lia

“…Interactions during cell adhesion to external surfaces may reach the level of discrimination of molecular chirality. Cultured epithelial cells interact…”
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Selective interactions of cells with crystal surfaces : implications for the mechanism of cell adhesion by HANEIN, D, SABANAY, H, ADDADI, L, GEIGER, B

“…In this study we have characterized the mode of cell adhesion to calcite and calcium (R,R)-tartrate tetrahydrate crystals. The use of crystals as adhesion…”
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