Search Results - "Handyside, A."

PGDIS Position Statement on the Transfer of Mosaic Embryos 2019 by Cram, D.S., Leigh, D., Handyside, A., Rechitsky, L., Xu, K., Harton, G., Grifo, J., Rubio, C., Fragouli, E., Kahraman, S., Forman, E., Katz-Jaffe, M., Tempest, H., Thornhill, A., Strom, C., Escudero, T., Qiao, J., Munne, S., Simpson, J.L., Kuliev, A.

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PGDIS position statement on the transfer of mosaic embryos 2021 by Leigh, D., Cram, D.S., Rechitsky, S., Handyside, A., Wells, D., Munne, S., Kahraman, S., Grifo, J., Katz-Jaffe, M., Rubio, C., Viotti, M., Forman, E., Xu, K., Gordon, T., Madjunkova, S., Qiao, J., Chen, Z.-J., Harton, G., Gianaroli, L., Simon, C., Scott, R., Simpson, J.L., Kuliev, A.

“…Chromosome testing strategies, such as preimplantation genetic testing for aneuploidy (PGT-A), improve initial IVF outcomes by avoiding unwitting transfer of…”
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Analysis of bovine blastocysts indicates ovarian stimulation does not induce chromosome errors, nor discordance between inner-cell mass and trophectoderm lineages by Tutt, D.A.R., Silvestri, G., Serrano-Albal, M., Simmons, R.J., Kwong, W.Y., Guven-Ates, G., Canedo-Ribeiro, C., Labrecque, R., Blondin, P., Handyside, A.H., Griffin, D.K., Sinclair, K.D.

“…Contemporary systems for oocyte retrieval and culture of both cattle and human embryos are suboptimal with respect to pregnancy outcomes following transfer. In…”
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Polar body array CGH for prediction of the status of the corresponding oocyte. Part I: clinical results by Geraedts, Joep, Montag, Markus, Magli, M. Cristina, Repping, Sjoerd, Handyside, Alan, Staessen, Catherine, Harper, Joyce, Schmutzler, Andreas, Collins, John, Goossens, Veerle, van der Ven, Hans, Vesela, Katerina, Gianaroli, Luca

“…BACKGROUND Several randomized controlled trials have not shown a benefit from preimplantation genetic screening (PGS) biopsy of cleavage-stage embryos and…”
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Array comparative genomic hybridisation on first polar bodies suggests that non-disjunction is not the predominant mechanism leading to aneuploidy in humans by Gabriel, A S, Thornhill, A R, Ottolini, C S, Gordon, A, Brown, A P C, Taylor, J, Bennett, K, Handyside, A, Griffin, D K

“…Aneuploidy (the presence of extra or missing chromosomes) arises primarily through chromosome segregation errors in the oocyte at meiosis I but the details of…”
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Nuclear organization in human sperm: preliminary evidence for altered sex chromosome centromere position in infertile males by Finch, K.A., Fonseka, K.G.L., Abogrein, A., Ioannou, D., Handyside, A.H., Thornhill, A.R., Hickson, N., Griffin, D.K.

“…BACKGROUND Many genetic defects with a chromosomal basis affect male reproduction via a range of different mechanisms. Chromosome position is a well-known…”
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Karyomapping (KM) as a universal preimplantation genetic diagnosis (PGD) for beta-globin gene (HBB) mutations combined with human leukocyte antigen (HLA) genotyping: a proof-of-principle study by Coskun, S, Qubbaj, W, AlHassan, S, Natesan, S, Awratani, K, Handyside, A

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Pregnancies from biopsied human preimplantation embryos sexed by Y-specific DNA amplification by Handyside, A. H, Kontogianni, E. H, Hardy, K, Winston, R. M. L

“…Over 200 recessive X chromosome-linked diseases, typically affecting only hemizygous males, have been identified. In many of these, prenatal diagnosis is…”
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O-226 Is there a place for polygenic risk scoring in PGT (PGT-P)? by Handyside, A H

“…Abstract Preimplantation genetic testing (PGT), by embryo biopsy and genetic testing for inherited diseases and chromosome abnormalities following IVF, is now…”
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Dense Single Nucleotide Polymorphism (SNP) Microarrays for the Identification of Aneuploidy and Consanguinity in Preimplantation Embryos by Brezina, P.R, Benner, A.T, Garcia, J, Zhao, Y, Handyside, A, Kearns, W.G

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Controlling misdiagnosis errors in preimplantation genetic diagnosis: a comprehensive model encompassing extrinsic and intrinsic sources of error by Lewis, C.M., Pinêl, T., Whittaker, J.C., Handyside, A.H.

“…We have developed a mathematical model to explore accuracy of preimplantation genetic diagnosis (PGD) using single cell polymerase chain reaction (PCR). The…”
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Chromosome translocations: segregation modes and strategies for preimplantation genetic diagnosis by Scriven, P. N., Handyside, A. H., Ogilvie, C. Mackie

“…Preimplantation genetic diagnosis (PGD) offers polymerase chain reaction tests for an increasing range of single gene defects, and fluorescence in situ…”
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Cytoskeletal analysis of human blastocysts by confocal laser scanning microscopy following vitrification by Chatzimeletiou, Katerina, Morrison, Ewan E, Panagiotidis, Yannis, Vanderzwalmen, Pierre, Prapas, Nikos, Prapas, Yannis, Tarlatzis, Basil C., Handyside, Alan H.

“…BACKGROUND Vitrification of human blastocysts is being used increasingly to cryopreserve supernumerary embryos following IVF. In this study, we investigate the…”
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Effects of pyruvate and glucose on the development of human preimplantation embryos in vitro by Conaghan, J, Handyside, A H, Winston, R M, Leese, H J

“…Although human embryos will develop in vitro for six days or more, little is known about the effects of the primary nutrients, pyruvate and glucose, on…”
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Increased number of cells and metabolic activity in male human preimplantation embryos following in vitro fertilization by Ray, P F, Conaghan, J, Winston, R M, Handyside, A H

“…The number of cells and metabolic activity of male and female human preimplantation embryos were examined to determine whether male embryos are more advanced…”
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Preimplantation genetic diagnosis: strategies and surprises by Handyside, Alan H., Delhanty, Joy D.A.

“…Several inherited diseases can now be diagnosed by genetic analysis of single cells biopsied from human eggs and preimplantation embryos following in vitro…”
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Birth of a Normal Girl after in Vitro Fertilization and Preimplantation Diagnostic Testing for Cystic Fibrosis by Handyside, Alan H, Lesko, John G, Tarín, Juan J, Winston, Robert M.L, Hughes, Mark R

“…PRENATAL diagnosis of inherited disease currently involves sampling cells of fetal origin by amniocentesis in the second trimester of pregnancy, or…”
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Day surgery sperm retrieval using pesa or tese with elective freezing: a retrospective review of 6 years experience and 292 cases by Balet, R, Thornhill, A.R, Handyside, A, Iammarrone, E, Shaw, L, Grudzinskas, G

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Is the sperm centrosome to blame for the complex polyploid chromosome patterns observed in cleavage stage embryos from an OAT patient? by Chatzimeletiou, K, Rutherford, A J, Griffin, D K, Handyside, A H

“…Oligoasthenoteratozoospermia (OAT) is defined by a combined low count < 20 x 10(6) sperm/ml, poor motility < 50 % forward progression or < 25 % rapid linear…”
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Detection of aneuploidy and chromosomal mosaicism in human embryos during preimplantation sex determination by fluorescent in situ hybridisation, (FISH) by Delhanty, J D, Griffin, D K, Handyside, A H, Harper, J, Atkinson, G H, Pieters, M H, Winston, R M

“…Five couples at risk of producing offspring with X-linked recessive disease underwent in vitro fertilisation with a view to preimplantation determination of…”
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