Search Results - "Handula, Maryana"

IEDDA: An Attractive Bioorthogonal Reaction for Biomedical Applications by Handula, Maryana, Chen, Kuo-Ting, Seimbille, Yann

“…The pretargeting strategy has recently emerged in order to overcome the limitations of direct targeting, mainly in the field of radioimmunotherapy (RIT). This…”
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Preclinical Evaluation of a PSMA-Targeting Homodimer with an Optimized Linker for Imaging of Prostate Cancer by Murce, Erika, Beekman, Savanne, Spaan, Evelien, Handula, Maryana, Stuurman, Debra, de Ridder, Corrina, Seimbille, Yann

“…Prostate-specific membrane antigen (PSMA) targeting radiopharmaceuticals have been successfully used for diagnosis and therapy of prostate cancer. Optimization…”
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Orthogonal synthesis of a versatile building block for dual functionalization of targeting vectors by Handula, Maryana, Chapeau, Dylan, Seimbille, Yann

“…Dual functionalization of targeting vectors, such as peptides and antibodies, is still synthetically challenging despite the increasing demand for such…”
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A Novel Luciferase-Based Reporter Gene Technology for Simultaneous Optical and Radionuclide Imaging of Cells by Gaspar, Natasa, Handula, Maryana, Stroet, Marcus C M, Marella-Panth, Kranthi, Haeck, Joost, Kirkland, Thomas A, Hall, Mary P, Encell, Lance P, Dalm, Simone, Lowik, Clemens, Seimbille, Yann, Mezzanotte, Laura

“…Multimodality reporter gene imaging combines the sensitivity, resolution and translational potential of two or more signals. The approach has not been widely…”
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Radiochemical and Biological Evaluation of 3p- C -NETA-ePSMA-16, a Promising PSMA-Targeting Agent for Radiotheranostics by Murce, Erika, Ahenkorah, Stephen, Beekman, Savanne, Handula, Maryana, Stuurman, Debra, de Ridder, Corrina, Cleeren, Frederik, Seimbille, Yann

“…Bifunctional chelators (BFCs) are a key element in the design of radiopharmaceuticals. By selecting a BFC that efficiently complexes diagnostic and therapeutic…”
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Synthesis and Evaluation of Two Long-Acting SSTR2 Antagonists for Radionuclide Therapy of Neuroendocrine Tumors by Koustoulidou, Sofia, Handula, Maryana, de Ridder, Corrina, Stuurman, Debra, Beekman, Savanne, de Jong, Marion, Nonnekens, Julie, Seimbille, Yann

“…Somatostatin receptor subtype 2 (SSTR2) has become an essential target for radionuclide therapy of neuroendocrine tumors (NETs). JR11 was introduced as a…”
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Synthesis and Evaluation of ePSMA-DM1: A New Theranostic Small-Molecule Drug Conjugate (T-SMDC) for Prostate Cancer by Murce, Erika, Spaan, Evelien, Beekman, Savanne, van den Brink, Lilian, Handula, Maryana, Stuurman, Debra, de Ridder, Corrina, Dalm, Simone U, Seimbille, Yann

“…Small-molecule drug conjugates (SMDCs) are compounds in which a therapeutic payload is conjugated to a targeting vector, for specific delivery to the tumor…”
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[ 212 Pb]Pb-eSOMA-01: A Promising Radioligand for Targeted Alpha Therapy of Neuroendocrine Tumors by Chapeau, Dylan, Koustoulidou, Sofia, Handula, Maryana, Beekman, Savanne, de Ridder, Corrina, Stuurman, Debra, de Blois, Erik, Buchatskaya, Yulia, van der Schilden, Karlijn, de Jong, Marion, Konijnenberg, Mark W, Seimbille, Yann

“…Peptide receptor radionuclide therapy (PRRT) has been applied to the treatment of neuroendocrine tumors (NETs) for over two decades. However, improvement is…”
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eTFC-01: a dual-labeled chelate-bridged tracer for SSTR2-positive tumors by Chapeau, Dylan, Beekman, Savanne, Handula, Maryana, Murce, Erika, de Ridder, Corrina, Stuurman, Debra, Seimbille, Yann

“…Background Integrating radioactive and optical imaging techniques can facilitate the prognosis and surgical guidance for cancer patients. Using a single…”
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Towards Complete Tumor Resection: Novel Dual-Modality Probes for Improved Image-Guided Surgery of GRPR-Expressing Prostate Cancer by Handula, Maryana, Verhoeven, Marjolein, Chen, Kuo-Ting, Haeck, Joost, de Jong, Marion, Dalm, Simone U, Seimbille, Yann

“…Nuclear and optical dual-modality probes can be of great assistance in prostate cancer localization, providing the means for both preoperative nuclear imaging…”
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First preclinical evaluation of [225Ac]Ac-DOTA-JR11 and comparison with [177Lu]Lu-DOTA-JR11, alpha versus beta radionuclide therapy of NETs by Handula, Maryana, Beekman, Savanne, Konijnenberg, Mark, Stuurman, Debra, de Ridder, Corrina, Bruchertseifer, Frank, Morgenstern, Alfred, Denkova, Antonia, de Blois, Erik, Seimbille, Yann

“…Background The [ 177 Lu]Lu-DOTA-TATE mediated peptide receptor radionuclide therapy (PRRT) of neuroendocrine tumors (NETs) is sometimes leading to treatment…”
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Development of C-terminal modified long-acting DOTA-JR11 analogs for optimized treatment of NETs by Handula, Maryana, Beekman, Savanne, Denkova, Antonia, Seimbille, Yann

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P-259 - Actinium-225 labeling of DOTATATE and DOTA-JR11 for the treatment of SSTR2-positive tumors by Handula, Maryana, de Blois, Erik, Denkova, Antonia, Seimbille, Yann

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Actinium-225 labeling of DOTATATE and DOTA-JR11 for the treatment of SSTR2-positive tumors by Handula, Maryana, de Blois, Erik, Denkova, Antonia, Seimbille, Yann

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Preclinical evaluation of ePSMA-DM1: a PSMA-targeting theranostic small molecule drug conjugate by Seimbille, Yann, Murce, Erika, Spaan, Evelien, Beekman, Savanne, Handula, Maryana, de Ridder, Corrina, Stuurman, Debra

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A novel clickable MSAP agent for dual fluorescence/nuclear labeling of biovectors by Chen, Kuo-Ting, Nieuwenhuizen, Jim, Handula, Maryana, Seimbille, Yann

“…We herein describe the development of a novel dual-modality optical/radio-imaging agent for general and site-specific labeling of biovectors through a…”
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P-260 - Albumin binders: a potential strategy for enhanced treatment of NETs using SSTR2 antagonists by Koustoulidou, Sofia, Handula, Maryana, Nonnekens, Julie, De Jong, Marion, Seimbille, Yann

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Albumin binders: a potential strategy for enhanced treatment of NETs using SSTR2 antagonists by Koustoulidou, Sofia, Handula, Maryana, Nonnekens, Julie, De Jong, Marion, Seimbille, Yann

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Radiochemical and Biological Evaluation of 3p-IC/I-NETA-ePSMA-16, a Promising PSMA-Targeting Agent for Radiotheranostics by Murce, Erika, Ahenkorah, Stephen, Beekman, Savanne, Handula, Maryana, Stuurman, Debra, de Ridder, Corrina, Cleeren, Frederik, Seimbille, Yann

“…Bifunctional chelators (BFCs) are a key element in the design of radiopharmaceuticals. By selecting a BFC that efficiently complexes diagnostic and therapeutic…”
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SP-083 - Development of versatile dual-modality imaging probes based on a GRPR antagonist for preoperative imaging and image-guided surgery of prostate cancer by Handula, Maryana, Verhoeven, Marjolein, Chen, Kuo-Ting, Haeck, Joost, Klomp, Ilva, De Bruin, Lisette, De Jong, Marion, Dalm, Simone, Seimbille, Yann

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