Search Results - "Handrick, R"

Activating Akt1 mutations alter DNA double strand break repair and radiosensitivity by Oeck, S., Al-Refae, K., Riffkin, H., Wiel, G., Handrick, R., Klein, D., Iliakis, G., Jendrossek, V.

“…The survival kinase Akt has clinical relevance to radioresistance. However, its contributions to the DNA damage response, DNA double strand break (DSB) repair…”
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911: Molecular mechanisms of the antineoplastic action of erufosine in hypoxic tumor cells by Riffkin, H, Oeck, S, Renzelman, G, Handrick, R, Jendrossek, V

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222: Chronic intermittent hypoxia triggers adaptive changes that promote protection against cell death by Matschke, J, Riffkin, H, Handrick, R, Klein-Hitpass, L, Jendrossek, V

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Mobilization of poly(3-hydroxybutyrate) in Ralstonia eutropha by Handrick, R, Reinhardt, S, Jendrossek, D

“…Ralstonia eutropha H16 degraded (mobilized) previously accumulated poly(3-hydroxybutyrate) (PHB) in the absence of an exogenous carbon source and used the…”
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additional loss of Bak and not the lack of the protein tyrosine kinase p56/Lck in one JCaM1.6 subclone caused pronounced apoptosis resistance in response to stimuli of the intrinsic pathway by Rudner, J, Mueller, A.-C, Matzner, N, Huber, S. M, Handrick, R, Belka, C, Jendrossek, V

“…Ionising radiation, hypoxia, and the cyclooxygenase-2 inhibitor Celecoxib are known agonists of the intrinsic apoptosis pathway that involves mitochondrial…”
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Importance of Bak/Bax for Efficacy of Radiochemotherapy in Colorectal Cancer by Mueller, A.C, Handrick, R, Daniel, P, Jendrossek, V, Belka, C

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Bcl-2 mediated inhibition of erucylphosphocholine-induced apoptosis depends on its subcellular localisation by Handrick, R., Rudner, J., Müller, I., Eibl, H., Belka, C., Jendrossek, V.

“…The synthetic phospholipid derivative erucylphosphocholine (ErPC) is a potent inducer of apoptosis in human tumor cell lines. This membrane-targeted drug…”
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369 Dihydroartemisinin is a hypoxia active anticancer drug by Ontikatze, T, Handrick, R, Grimm, F, Henke, G, Daniel, P.T, Belka, C, Jendrossek, V

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Combined treatment with membrane targeted apoptosis modulators and ionising radiation increases apoptotic signaling at the mitochondria by Rübel, A, Handrick, R, Belka, C, Jendrossek, V

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Dihydroartemisinin-induced apoptosis depends on the presence of proapoptotic Bax or Bak and increases efficacy of ionizing radiation and targeted chemotherapy in vitro by Ontikatze, T, Bauer, K.D, Rübel, A, Freier, F, Belka, C, Jendrossek, V, Handrick, R

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330 POSTER Dihydroartemisinin induces Bak-dependent mitochondrial apoptosis in tumour cells and increases efficacy of ionizing radiation by Handrick, R, Bauer, K.D, Freier, F, Belka, C, Jendrossek, V

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322 POSTER Molecular determinants of radiation response modulation by TNF-related apoptosis inducing ligand (TRAIL): Role of the pro-apoptotic Bcl-2 protein Bak by Ruebel, A, Marini, P, Handrick, R, Belka, C, Jendrossek, V

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308 POSTER Celecoxib-induced apoptosis depends on Bak and is only marginally modified by Bcl-2 overexpression by Müller, A, Handrick, R, Henke, G, Belka, C, Jendrossek, V

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MICROBIAL DEGRADATION OF POLYHYDROXYALKANOATES by Jendrossek, Dieter, Handrick, René

“…Polyesters such as poly(3-hydroxybutyrate) (PHB) or other polyhydroxyalkanoates (PHA) have attracted commercial and academic interest as new biodegradable…”
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335 POSTER Irradiation-induced side-effects in the lung: establishment of a murine model for analysis of physiological and histological alterations by Eldh, T, Velalakan, A, Heinzelmann, F, Handrick, R, Eltzschig, H, Uhlig, S, Budach, W, Belka, C, Jendrossek, V

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Celecoxib activates a novel mitochondrial apoptosis signaling pathway by Jendrossek, Verena, Handrick, René, Belka, Claus

“…ABSTRACT The cyclooxygenase (COX)‐2 inhibitor Celecoxib may inhibit cancer cell growth independently of its capacity to block the COX‐2 enzyme. The growth…”
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Membrane targeted anticancer drugs: potent inducers of apoptosis and putative radiosensitisers by Jendrossek, V, Handrick, R

“…In the last two decades, cellular membranes have been identified as novel targets for antineoplastic drugs. Two classes of synthetic phospholipid analogues:…”
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The “Intracellular” Poly(3-Hydroxybutyrate) (PHB) Depolymerase of Rhodospirillum rubrum Is a Periplasm-Located Protein with Specificity for Native PHB and with Structural Similarity to Extracellular PHB Depolymerases by HANDRICK, René, REINHARDT, Simone, KIMMIG, Philipp, JENDROSSEK, Dieter

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A New Type of Thermoalkalophilic Hydrolase of Paucimonas lemoignei with High Specificity for Amorphous Polyesters of Short Chain-length Hydroxyalkanoic Acids by Handrick, René, Reinhardt, Simone, Focarete, Maria Letizia, Scandola, Mariastella, Adamus, Grazyna, Kowalczuk, Marek, Jendrossek, Dieter

“…A novel type of hydrolase was purified from culture fluid of Paucimonas (formerlyPseudomonas) lemoignei. Biochemical characterization revealed an unusual…”
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Proapoptotic activity of Ukrain is based on Chelidonium majus L. alkaloids and mediated via a mitochondrial death pathway by Habermehl, Daniel, Kammerer, Bernd, Handrick, René, Eldh, Therese, Gruber, Charlotte, Cordes, Nils, Daniel, Peter T, Plasswilm, Ludwig, Bamberg, Michael, Belka, Claus, Jendrossek, Verena

“…The anticancer drug Ukrain (NSC-631570) which has been specified by the manufacturer as semisynthetic derivative of the Chelidonium majus L. alkaloid…”
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