Search Results - "Handley, Ava"

PIE-scope, integrated cryo-correlative light and FIB/SEM microscopy by Gorelick, Sergey, Buckley, Genevieve, Gervinskas, Gediminas, Johnson, Travis K, Handley, Ava, Caggiano, Monica Pia, Whisstock, James C, Pocock, Roger, de Marco, Alex

“…Cryo-electron tomography (cryo-ET) is emerging as a revolutionary method for resolving the structure of macromolecular complexes in situ. However, sample…”
Get full text

Neuro-intestinal acetylcholine signalling regulates the mitochondrial stress response in Caenorhabditis elegans by Cornell, Rebecca, Cao, Wei, Harradine, Bernie, Godini, Rasoul, Handley, Ava, Pocock, Roger

“…Neurons coordinate inter-tissue protein homeostasis to systemically manage cytotoxic stress. In response to neuronal mitochondrial stress, specific neuronal…”
Get full text

Diet-responsive transcriptional regulation of insulin in a single neuron controls systemic metabolism by Handley, Ava, Wu, Qiuli, Sherry, Tessa, Cornell, Rebecca, Pocock, Roger

“…Metabolic homeostasis is coordinated through a robust network of signaling pathways acting across all tissues. A key part of this network is insulin-like…”
Get full text

Transcription Factors That Control Behavior—Lessons From C. elegans by Godini, Rasoul, Handley, Ava, Pocock, Roger

“…Behavior encompasses the physical and chemical response to external and internal stimuli. Neurons, each with their own specific molecular identities, act in…”
Get full text

Nuclear factor Y is a pervasive regulator of neuronal gene expression by Moreira, Pedro, Papatheodorou, Paul, Deng, Shuer, Gopal, Sandeep, Handley, Ava, Powell, David R., Pocock, Roger

“…Nervous system function relies on the establishment of complex gene expression programs that provide neuron-type-specific and core pan-neuronal features. These…”
Get full text

Interferon-β-induced miR-1 alleviates toxic protein accumulation by controlling autophagy by Nehammer, Camilla, Ejlerskov, Patrick, Gopal, Sandeep, Handley, Ava, Ng, Leelee, Moreira, Pedro, Lee, Huikyong, Issazadeh-Navikas, Shohreh, Rubinsztein, David C, Pocock, Roger

“…Appropriate regulation of autophagy is crucial for clearing toxic proteins from cells. Defective autophagy results in accumulation of toxic protein aggregates…”
Get full text

A Protein Disulfide Isomerase Controls Neuronal Migration through Regulation of Wnt Secretion by Torpe, Nanna, Gopal, Sandeep, Baltaci, Oguzhan, Rella, Lorenzo, Handley, Ava, Korswagen, Hendrik C., Pocock, Roger

“…Appropriate Wnt morphogen secretion is required to control animal development and homeostasis. Although correct Wnt globular structure is essential for…”
Get full text

Transcriptional control of satiety in Caenorhabditis elegans by Handley, Ava, Pocock, Roger

“…Obesity is an enormous worldwide health concern. Chronic illnesses associated with obesity include type-2 diabetes, hypertension, atherosclerosis and certain…”
Get full text

Atypical TGF-β signaling controls neuronal guidance in Caenorhabditis elegans by Baltaci, Oguzhan, Pedersen, Mikael Egebjerg, Sherry, Tessa, Handley, Ava, Snieckute, Goda, Cao, Wei, Haas, Matilda, Archer, Stuart, Pocock, Roger

“…Coordinated expression of cell adhesion and signaling molecules is crucial for brain development. Here, we report that the Caenorhabditis elegans transforming…”
Get full text

CAST-ChIP Maps Cell-Type-Specific Chromatin States in the Drosophila Central Nervous System by Schauer, Tamás, Schwalie, Petra C., Handley, Ava, Margulies, Carla E., Flicek, Paul, Ladurner, Andreas G.

“…Chromatin organization and gene activity are responsive to developmental and environmental cues. Although many genes are transcribed throughout development and…”
Get full text

Harmonization of L1CAM expression facilitates axon outgrowth and guidance of a motor neuron by Sherry, Tessa, Handley, Ava, Nicholas, Hannah R, Pocock, Roger

“…Brain development requires precise regulation of axon outgrowth, guidance and termination by multiple signaling and adhesion molecules. How the expression of…”
Get full text

Designing Cell-Type-Specific Genome-wide Experiments by Handley, Ava, Schauer, Tamás, Ladurner, Andreas G., Margulies, Carla E.

“…Multicellular organisms depend on cell-type-specific division of labor for survival. Specific cell types have their unique developmental program and respond…”
Get full text

Harmonization of L1CAM expression facilitates axon outgrowth and guidance of a motor neuron by Sherry, Tessa, Handley, Ava, Nicholas, Hannah R, Pocock, Roger

“…Brain development requires precise regulation of axon outgrowth, guidance and termination by multiple signaling and adhesion molecules. How the expression of…”
Get full text

Interferon-[beta]-induced miR-1 alleviates toxic protein accumulation by controlling autophagy by Nehammer, Camilla, Ejlerskov, Patrick, Gopal, Sandeep, Handley, Ava, Ng, Leelee, Moreira, Pedro, Lee, Huikyong, Issazadeh-Navikas, Shohreh, Rubinsztein, David C, Pocock, Roger

“…Appropriate regulation of autophagy is crucial for clearing toxic proteins from cells. Defective autophagy results in accumulation of toxic protein aggregates…”
Get full text