Search Results - "Handl, Verena"
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Continuous iontronic chemotherapy reduces brain tumor growth in embryonic avian in vivo models
Published in Journal of controlled release (01-05-2024)“…Local and long-lasting administration of potent chemotherapeutics is a promising therapeutic intervention to increase the efficiency of chemotherapy of…”
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Blockage of Store-Operated Ca2+ Influx by Synta66 is Mediated by Direct Inhibition of the Ca2+ Selective Orai1 Pore
Published in Cancers (06-10-2020)“…The Ca2+ sensor STIM1 and the Ca2+ channel Orai1 that form the store-operated Ca2+ (SOC) channel complex are key targets for drug development. Selective SOC…”
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Blockage of Store-Operated Ca 2+ Influx by Synta66 is Mediated by Direct Inhibition of the Ca 2+ Selective Orai1 Pore
Published in Cancers (06-10-2020)“…The Ca sensor STIM1 and the Ca channel Orai1 that form the store-operated Ca (SOC) channel complex are key targets for drug development. Selective SOC…”
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Journal Article -
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Blockage of Store-Operated [Ca.sup.2+] Influx by Synta66 is Mediated by Direct Inhibition of the [Ca.sup.2+] Selective Orai1 Pore
Published in Cancers (01-10-2020)“…Store-operated calcium channels constituted from the proteins Orai and STIM are important targets for development of new drugs, especially for the treatment of…”
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Targeted Chemotherapy of Glioblastoma Spheroids with an Iontronic Pump
Published in Advanced materials technologies (01-05-2021)“…Successful treatment of glioblastoma multiforme (GBM), the most lethal tumor of the brain, is presently hampered by (i) the limits of safe surgical resection…”
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Targeted Chemotherapy: Targeted Chemotherapy of Glioblastoma Spheroids with an Iontronic Pump (Adv. Mater. Technol. 5/2021)
Published in Advanced materials technologies (01-05-2021)“…In article number 2001302, Silke Patz, Daniel T. Simon, Rainer Schindl, and co‐workers engineer an electronically‐driven ion pump for the targeted delivery of…”
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