Search Results - "Handl, Heather L."

Lanthanide-based luminescent assays for ligand-receptor interactions by Handl, Heather L., Gillies, Robert J.

“…The evaluation of receptor ligand interactions is important in the field of drug discovery and development. Currently these interactions are typically measured…”
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Heterobivalent Ligands Crosslink Multiple Cell-Surface Receptors: The Human Melanocortin-4 and δ-Opioid Receptors by Vagner, Josef, Xu, Liping, Handl, Heather L, Josan, Jatinder S, Morse, David L, Mash, Eugene A, Gillies, Robert J, Hruby, Victor J

“…Together we bind: A series of synthetic heterobivalent ligands containing a fragment of melanocyte stimulating hormone analogue MSH(7) and the δ‐opioid ligand…”
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Use of PD-1 and PD-L1 inhibitors after first-line therapy in esophageal cancer patients in the US by Allaire, Jason C., Balk, Mark, Azmi, Soraya, Handl, Heather L., Yang, Keri, Barnes, Gisoo

“…Esophageal cancer (EC) makes up 3.2% of all cancers but ranks sixth among cancer-related deaths worldwide. This real-world analysis determined the use of…”
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Cell-Specific Targeting by Heterobivalent Ligands by Josan, Jatinder S, Handl, Heather L, Sankaranarayanan, Rajesh, Xu, Liping, Lynch, Ronald M, Vagner, Josef, Mash, Eugene A, Hruby, Victor J, Gillies, Robert J

“…Current cancer therapies exploit either differential metabolism or targeting to specific individual gene products that are overexpressed in aberrant cells. The…”
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Synthesis and Evaluation of Bivalent NDP-α-MSH(7) Peptide Ligands for Binding to the Human Melanocortin Receptor 4 (hMC4R) by Handl, Heather L, Sankaranarayanan, Rajesh, Josan, Jatinder S, Vagner, Josef, Mash, Eugene A, Gillies, Robert J, Hruby, Victor J

“…We demonstrate the potential utility of multivalent ligands as targeting agents for cancer imaging or therapy by determining the binding of homobivalent…”
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Hitting multiple targets with multimeric ligands by Handl, Heather L, Vagner, Josef, Han, Haiyong, Mash, Eugene, Hruby, Victor J, Gillies, Robert J

“…Multimeric ligands consist of multiple monomeric ligands attached to a single backbone molecule, creating a multimer that can bind to multiple receptors or…”
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Lanthanide-based time-resolved fluorescence of in cyto ligand–receptor interactions by Handl, Heather L, Vagner, Josef, Yamamura, Henry I, Hruby, Victor J, Gillies, Robert J

“…A lanthanide-based assay for ligand–receptor interactions provides an attractive alternative to the traditional radiolabeled determinations in terms of…”
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Novel targeting strategy based on multimeric ligands for drug delivery and molecular imaging: homooligomers of α-MSH by Vagner, Josef, Handl, Heather L., Gillies, Robert J., Hruby, Victor J.

“…Homooligomers constructed with 4- and 6-amino acid fragments of melanocortin (α-MSH) bind with higher affinity and with apparent cooperativity to melanocortin…”
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Development of a lanthanide-based assay for detection of receptor–ligand interactions at the δ-opioid receptor by Handl, Heather L., Vagner, Josef, Yamamura, Henry I., Hruby, Victor J., Gillies, Robert J.

“…A lanthanide-based assay for ligand–receptor interactions provides an attractive alternative to the traditional radiolabeled determinations in terms of…”
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Solid-Phase Synthesis of Heterobivalent Ligands Targeted to Melanocortin and Cholecystokinin Receptors by Josan, Jatinder S., Vagner, Josef, Handl, Heather L., Sankaranarayanan, Rajesh, Gillies, Robert J., Hruby, Victor J.

“…Heteromultivalency provides a route to increase binding avidity and to high specificity when compared to monovalent ligands. The enhanced specificity can…”
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Rigid Linkers for Bioactive Peptides by Vagner, Josef, Handl, Heather L, Monguchi, Yasunari, Jana, Umasish, Begay, Lucinda J, Mash, Eugene A, Hruby, Victor J, Gillies, Robert J

“…Rigid linkers of variable length were used to connect two high-affinity Nle4-D-Phe7-α-melanocyte stimulating hormone (NDP-α-MSH) or two low-affinity MSH(4)…”
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Heterobivalent ligands crosslink multiple cell-surface receptors--a step towards personal medicine by Josan, Jatinder S, Sankaranarayanan, Rajesh, Handl, Heather L, Fernandes, Steve, Xu, Liping, Vagner, Josef, Gillies, Robert J, Hruby, Victor J

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Novel furano analogues of duocarmycin C1 and C2: design, synthesis, and biological evaluation of seco-iso-Cyclopropylfurano[2,3- e]indoline ( seco-iso-CFI) and seco-Cyclopropyltetrahydrofurano[2,3- f]quinoline ( seco-CFQ) analogues by Howard, Tiffany T., Lingerfelt, Brian M., Purnell, Bethany L., Scott, Adrienne E., Price, Carly A., Townes, Heather M., McNulty, LuAnne, Handl, Heather L., Summerville, Kaitlin, Hudson, Stephen J., Bowen, J.Phillip, Kiakos, Konstantinos, Hartley, John A., Lee, Moses

“…The design, synthesis and biological evaluation of novel seco-iso-cyclopropylfurano[2,3- e]indoline ( seco-iso-CFI) and the…”
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Sequence specific recognition of DNA by tailor-made hairpin conjugates of achiral seco-cyclopropaneindoline-2-benzofurancarboxamide and pyrrole–imidazole polyamides by Price, Carly A., Lingerfelt, Brian M., Handl, Heather L., Kiakos, Konstantinos, Hartley, John A., Lee, Moses

“…[Display omitted] Hairpin conjugates of achiral seco-cyclopropaneindoline-2-benzofurancarboxamide (achiral seco-CI-Bf) and three diamides (ImPy 1, PyIm 2, and…”
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Sequence selective recognition of DNA by hairpin conjugates of a racemic seco-cyclopropaneindoline-2-benzofurancarboxamide and polyamides by Toth, James L, Price, Carly A, Madsen, Erik C, Handl, Heather L, Hudson, Stephen J, Hubbard, III, Richard B, Bowen, J.Phillip, Kiakos, Konstantinos, Hartley, John A, Lee, Moses

“…Conjugates of racemic seco-cyclopropaneindoline-2-benzofurancarboxamide (CI-Bf) and four diamides (ImIm 1, ImPy 2, PyIm 3, and PyPy 4, where Py is pyrrole, and…”
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Synthesis and Evaluation of Bivalent NDP-¿-MSH(7) Peptide Ligands for Binding to the Human Melanocortin Receptor 4 (hMC4R) by Handl, Heather L, Sankaranarayanan, Rajesh, Josan, Jatinder S, Vagner, Josef

“…We demonstrate the potential utility of multivalent ligands as targeting agents for cancer imaging or therapy by determining the binding of homobivalent…”
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Design, synthesis, and validation of rigid linkers for bioactive peptides by Monguchi, Yasunari, Vagner, Josef, Handl, Heather L., Jana, Umasish, Begay, Lucinda J., Hruby, Victor J., Gillies, Robert J., Mash, Eugene A.

“…Rigid linkers of variable length were synthesized and used to connect two NDP-α-MSH ligands. The linkers were incorporated by solid-phase synthesis. Biological…”
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Heterobivalent Ligands Crosslink Multiple Cell-Surface Receptors: The Human Melanocortin-4 and δ-Opioid Receptors by Vagner, Josef, Xu, Liping, Handl, Heather L., Josan, Jatinder S., Morse, David L., Mash, Eugene A., Gillies, Robert J., Hruby, Victor J.

“…Gemeinsame Anbindung: Eine Reihe synthetischer heterodivalenter Liganden aus einem Fragment des melanozytenstimulierenden Hormonanalogons MSH(7) und dem…”
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Heterobivalent Ligands Crosslink Multiple Cell‐Surface Receptors: The Human Melanocortin‐4 and δ‐Opioid Receptors by Vagner, Josef, Xu, Liping, Handl, Heather L., Josan, Jatinder S., Morse, David L., Mash, Eugene A., Gillies, Robert J., Hruby, Victor J.

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