Search Results - "Handel, T M"

Chemokine oligomerization and interactions with receptors and glycosaminoglycans: The role of structural dynamics in function by Salanga, C.L., Handel, T.M.

“…The first chemokine structure, that of IL-8/CXCL8, was determined in 1990. Since then, many chemokine structures have emerged. To the initial disappointment of…”
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Interaction of chemokines and glycosaminoglycans: A new twist in the regulation of chemokine function with opportunities for therapeutic intervention by Johnson, Z., Proudfoot, A.E., Handel, T.M.

“…Despite their key role in inflammation, the apparent redundancy in the chemokine system is often cited as an argument against probing chemokines as therapeutic…”
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Regulation of protein function by glycosaminoglycans--as exemplified by chemokines by Handel, T M, Johnson, Z, Crown, S E, Lau, E K, Proudfoot, A E

“…Immune modulators such as cytokines and growth factors exert their biological activity through high-affinity interactions with cell-surface receptors, thereby…”
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Mechanisms and consequences of the loss of PHLPP1 phosphatase in chronic lymphocytic leukemia (CLL) by O'Hayre, M, Niederst, M, Fecteau, J F, Nguyen, V M, Kipps, T J, Messmer, D, Newton, A C, Handel, T M

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Quantum Mechanical Design of Enzyme Active Sites by Zhang, Xiyun, DeChancie, Jason, Gunaydin, Hakan, Chowdry, Arnab B, Clemente, Fernando R, Smith, Handel, T. M, Houk, K. N

“…The design of active sites has been carried out using quantum mechanical calculations to predict the rate-determining transition state of a desired reaction in…”
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De novo design of the hydrophobic cores of proteins by Desjarlais, John R., Handel, Tracy M.

“…We have developed and experimentally tested a novel computational approach for the de novo design of hydrophobic cores. A pair of computer programs has been…”
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De novo design of the hydrophobic core of ubiquitin by Lazar, Greg A., Desjarlais, John R., Handel, Tracy M.

“…We have previously reported the development and evaluation of a computational program to assist in the design of hydrophobic cores of proteins. In an effort to…”
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From coiled coils to small globular proteins: Design of a native‐like three‐helix bundle by Bryson, James W., Desjarlais, John R., Handel, Tracy M., Degrado, William F.

“…A monomolecular native‐like three‐helix bundle has been designed in an iterative process, beginning with a peptide that noncooperatively assembled into an…”
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Metal Ion-Dependent Modulation of the Dynamics of a Designed Protein by Handel, Tracy M., Williams, Scott A., DeGrado, William F.

“…The peptide $\alpha_4$ is a designed four-helix bundle that contains a highly simplified hydrophobic core composed exclusively of leucine residues; its…”
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Glycosaminoglycan Binding and Oligomerization Are Essential for the in vivo Activity of Certain Chemokines by Amanda E. I. Proudfoot, Handel, Tracy M., Johnson, Zoë, Lau, Elaine K., LiWang, Patricia, Clark-Lewis, Ian, Borlat, Frédéric, Timothy N. C. Wells, Kosco-Vilbois, Marie H.

“…During organogenesis, immunosurveillance, and inflammation, chemokines selectively recruit leukocytes by activating seven-transmembrane-spanning receptors. It…”
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Identification of the glycosaminoglycan binding site of the CC chemokine, MCP-1: implications for structure and function in vivo by Lau, Elaine K, Paavola, Chad D, Johnson, Zoë, Gaudry, Jean-Philippe, Geretti, Elena, Borlat, Frédéric, Kungl, Andreas J, Proudfoot, Amanda E, Handel, Tracy M

“…In a recent study, we demonstrated that glycosaminoglycan (GAG) binding and oligomerization are essential for the in vivo function of the chemokines…”
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Folding of an isolated ribonuclease H core fragment by CHAMBERLAIN, AARON K., FISCHER, KAEL F., REARDON, DEIRDRE, HANDEL, TRACY M., MARQUSEE, SUSAN

“…Based on results from both equilibrium and kinetic hydrogen exchange studies of Escherichia coli ribonuclease HI (RNase H), a fragment of RNase H (eABCD) was…”
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Review: Protein Design—Where We Were, Where We Are, Where We're Going by Pokala, Navin, Handel, Tracy M.

“…Protein design has become a powerful approach for understanding the relationship between amino acid sequence and 3-dimensional structure. In the past 5 years,…”
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Rotamer strain as a determinant of protein structural specificity by LAZAR, GREG A., JOHNSON, ERIC C., DESJARLAIS, JOHN R., HANDEL, TRACY M.

“…We present direct evidence for a change in protein structural specificity due to hydrophobic core packing. High resolution structural analysis of a designed…”
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Side-chain and backbone flexibility in protein core design by Desjarlais, J R, Handel, T M

“…We have developed a computational approach for the design and prediction of hydrophobic cores that includes explicit backbone flexibility. The program consists…”
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Detection of rare partially folded molecules in equilibrium with the native conformation of RNaseH by Chamberlain, Aaron K, Handel, Tracy M, Marqusee, Susan

“…Despite the general observation that single domain proteins denature in a completely cooperative manner, amide hydrogen exchange of ribonuclease H in low…”
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Heteronuclear (1H, 13C, 15N) NMR assignments and secondary structure of the basic region‐helix‐loop‐helix domain of E47 by Fairman, Robert, Beran‐Steed, Rita K., Handel, Tracy M.

“…E47 is an immunoglobulin enhancer DNA‐binding protein that contains a basic region‐helix‐loop‐helix (b/HLH) domain. This structural motif defines a class of…”
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Identification of Residues in the Monocyte Chemotactic Protein-1 That Contact the MCP-1 Receptor, CCR2 by Hemmerich, Stefan, Paavola, Chad, Bloom, Adam, Bhakta, Sunil, Freedman, Richard, Grunberger, Dorit, Krstenansky, John, Lee, Simon, McCarley, Debbie, Mulkins, Mary, Wong, Belinda, Pease, Joe, Mizoue, Laura, Mirzadegan, Tara, Polsky, Irene, Thompson, Kelly, Handel, Tracy M, Jarnagin, Kurt

“…The CC chemokine, MCP-1, has been identified as a major chemoattractant for T cells and monocytes, and plays a significant role in the pathology of…”
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Monomeric Monocyte Chemoattractant Protein-1 (MCP-1) Binds and Activates the MCP-1 Receptor CCR2B by Paavola, C D, Hemmerich, S, Grunberger, D, Polsky, I, Bloom, A, Freedman, R, Mulkins, M, Bhakta, S, McCarley, D, Wiesent, L, Wong, B, Jarnagin, K, Handel, T M

“…To address the role of dimerization in the function of the monocyte chemoattractant protein-1, MCP-1, we mutated residues that comprise the core of the…”
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Analysis of an orf virus chemokine-binding protein: shifting ligand specificities among a family of poxvirus viroceptors by Seet, B.T, McCaughan, C.A, Handel, T.M, Mercer, A, Brunetti, C, McFadden, G, Fleming, S.B

“…We identify a secreted chemokine inhibitor encoded by orf virus (ORFV), the prototypic poxvirus of the Parapoxvirus genus, and show that it is related to the…”
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