Search Results - "Hande, M P"

A positive role for c-Abl in Atm and Atr activation in DNA damage response by Wang, X, Zeng, L, Wang, J, Chau, J F L, Lai, K P, Jia, D, Poonepalli, A, Hande, M P, Liu, H, He, G, He, L, Li, B

“…DNA damage triggers Atm- and/or Atr-dependent signaling pathways to control cell cycle progression, apoptosis, and DNA repair. However, how Atm and Atr are…”
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Rad54 and Mus81 cooperation promotes DNA damage repair and restrains chromosome missegregation by Ghamrasni, S El, Cardoso, R, Li, L, Guturi, K K N, Bjerregaard, V A, Liu, Y, Venkatesan, S, Hande, M P, Henderson, J T, Sanchez, O, Hickson, I D, Hakem, A, Hakem, R

“…Rad54 and Mus81 mammalian proteins physically interact and are important for the homologous recombination DNA repair pathway; however, their functional…”
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The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo by Liu, Y, Snow, B.E, Hande, M.P, Yeung, D, Erdmann, N.J, Wakeham, A, Itie, A, Siderovski, D.P, Lansdorp, P.M, Robinson, M.O, Harrington, L

“…Mammalian telomerase is essential for the maintenance of telomere length [1–5]. Its catalytic core comprises a reverse transcriptase component (TERT) and an…”
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c-Jun N-terminal kinase mediates hydrogen peroxide-induced cell death via sustained poly(ADP-ribose) polymerase-1 activation by Zhang, S, Lin, Y, Kim, Y-S, Hande, M P, Liu, Z-G, Shen, H-M

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DNA repair factors and telomere-chromosome integrity in mammalian cells by Hande, M P

“…Loss of telomere equilibrium and associated chromosome-genomic instability might effectively promote tumour progression. Telomere function may have contrasting…”
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Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability by Jackson, Stephen P, Fagagna, Fabrizio d'Adda di, Hande, M. Prakash, Tong, Wei-Min, Lansdorp, Peter M, Wang, Zhao-Qi

“…In most eukaryotes, poly(ADP-ribose) polymerase (PARP) recognizes DNA strand interruptions generated in vivo. DNA binding by PARP triggers primarily its own…”
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Extra-chromosomal telomeric DNA in cells from Atm-/- mice and patients with ataxia-telangiectasia by PRAKASH HANDE, M, BALAJEE, Adayabalam S, TCHIRKOV, Andrei, WYNSHAW-BORIS, Anthony, LANSDORP, Peter M

“…Ataxia-telangiectasia (AT) is an autosomally recessive human genetic disease with pleiotropic defects such as neurological degeneration, immunodeficiency,…”
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Routine screening mammography: how important is the radiation-risk side of the benefit-risk equation? by Brenner, D. J., Sawant, S. G., Hande, M. P., Miller, R. C., Elliston, C. D., Fu, Z., Randers-Pehrson, G., Marino, S. A.

“…The potential radiation hazards associated with routine screening mammography, in terms of breast cancer induction, are discussed in the context of the…”
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Allelic imbalance at 11q23-q24 chromosome associated with estrogen and radiation-induced breast cancer progression by ROY, D, CALAF, G. M, HANDE, M. P, HEI, T. K

“…Multiple genetic alterations are common in cancers including those of the breast. The mechanisms leading to these alterations such as point mutations, gene…”
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c-Jun N-terminal kinase mediates hydrogen peroxide-induced cell death via sustained poly(ADP-ribose) polymerase-1 activation by Zhang, S, Lin, Y, Kim, Y-S, Hande, M P, Liu, Z-G, Shen, H-M

“…Reactive oxygen species (ROS) have been closely associated with both apoptotic and non-apoptotic/necrotic cell death. Our previous study has illustrated that…”
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Cooperation of Blm and Mus81 in development, fertility, genomic integrity and cancer suppression by El Ghamrasni, S, Cardoso, R, Halaby, M J, Zeegers, D, Harding, S, Kumareswaran, R, Yavorska, T, Chami, N, Jurisicova, A, Sanchez, O, Hande, M P, Bristow, R, Hakem, R, Hakem, A

“…BLM is a DNA helicase important for the restart of stalled replication forks and for homologous recombination (HR) repair. Mutations of BLM lead to Bloom…”
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Accelerated Telomere Shortening in the Human Inactive X Chromosome by Surrallés, Jordi, Hande, M. Prakash, Marcos, Ricard, Lansdorp, Peter M.

“…Telomeres are nucleoprotein complexes at the end of eukaryotic chromosomes, with important roles in the maintenance of genomic stability and in chromosome…”
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Inactivation of 14-3-3ς Influences Telomere Behavior and Ionizing Radiation-Induced Chromosomal Instability by Dhar, Sonu, Squire, Jeremy A., Hande, M. Prakash, Wellinger, Raymund J., Pandita, Tej K.

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Telomerase-Associated Protein TEP1 Is Not Essential for Telomerase Activity or Telomere Length Maintenance In Vivo by Liu, Yie, Snow, Bryan E., Hande, M. Prakash, Baerlocher, Gabriela, Kickhoefer, Valerie A., Yeung, David, Wakeham, Andrew, Itie, Annick, Siderovski, David P., Lansdorp, Peter M., Robinson, Murray O., Harrington, Lea

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Chinese hamster telomeres are comparable in size to mouse telomeres by Slijepcevic, P, Hande, M P

“…We report here the results of a telomere length analysis in four male Chinese hamsters by quantitative fluorescence in situ hybridization (Q-FISH). We were…”
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Induction and persistence of cytogenetic damage in mouse splenocytes following whole-body X-irradiation analysed by fluorescence in situ hybridization. IV. Dose response by HANDE, M. P, NATARAJAN, A. T

“…Purpose: To develop a mouse model for retrospective biological dosimetry, the kinetics of induction and persistence of chromosome aberrations following…”
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Telomere length, chromatin structure and chromosome fusigenic potential by Slijepcevic, P, Hande, M P, Bouffler, S D, Lansdorp, P, Bryant, P E

“…Telomeres are specialized structures at chromosome ends that are thought to function as buffers against chromosome fusion. Several studies suggest that…”
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Induction and persistence of cytogenetic damage in mouse splenocytes following whole-body X-irradiation analysed by fluorescence in situ hybridization. I. Dicentrics and translocations by Hande, M P, Boei, J J, Granath, F, Natarajan, A T

“…Chromosome translocations (stable aberrations) can persist longer during cellular proliferation than dicentrics (unstable aberrations). It is important to know…”
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Induction of cancer, actinic keratosis, and specific p53 mutations by UVB light in human skin maintained in severe combined immunodeficient mice by NOMURA, T, NAKAJIMA, H, UEDA, M, TAKATERA, H, HONGYO, T, TANIGUCHI, E, FUKUDA, K, LI YA LI, KUROOKA, M, SUTOH, K, HANDE, P. M, KAWAGUCHI, T

“…To study the mechanism and risk of human skin cancer from solar light, we exposed human skin transplanted to severe combined immunodeficient mice to daily…”
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Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA by Blasco, María A, Lee, Han-Woong, Hande, M.Prakash, Samper, Enrique, Lansdorp, Peter M, DePinho, Ronald A, Greider, Carol W

“…To examine the role of telomerase in normal and neoplastic growth, the telomerase RNA component ( mTR) was deleted from the mouse germline. mTR −/− mice lacked…”
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