Search Results - "Handal, Laura S"

A highly potent human neutralizing antibody prevents vertical transmission of Rift Valley fever virus in a rat model by McMillen, Cynthia M., Chapman, Nathaniel S., Hoehl, Ryan M., Skvarca, Lauren B., Schwarz, Madeline M., Handal, Laura S., Crowe, James E., Hartman, Amy L.

“…Rift Valley fever virus (RVFV) is an emerging mosquito-transmitted virus that circulates in livestock and humans in Africa and the Middle East. Outbreaks lead…”
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An antibody targeting the N-terminal domain of SARS-CoV-2 disrupts the spike trimer by Suryadevara, Naveenchandra, Shiakolas, Andrea R, VanBlargan, Laura A, Binshtein, Elad, Chen, Rita E, Case, James Brett, Kramer, Kevin J, Armstrong, Erica C, Myers, Luke, Trivette, Andrew, Gainza, Christopher, Nargi, Rachel S, Selverian, Christopher N, Davidson, Edgar, Doranz, Benjamin J, Diaz, Summer M, Handal, Laura S, Carnahan, Robert H, Diamond, Michael S, Georgiev, Ivelin S, Crowe, Jr, James E

“…The protective human antibody response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) focuses on the spike (S) protein, which decorates the…”
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Multifunctional human monoclonal antibody combination mediates protection against Rift Valley fever virus at low doses by Chapman, Nathaniel S., Hulswit, Ruben J. G., Westover, Jonna L. B., Stass, Robert, Paesen, Guido C., Binshtein, Elad, Reidy, Joseph X., Engdahl, Taylor B., Handal, Laura S., Flores, Alejandra, Gowen, Brian B., Bowden, Thomas A., Crowe, James E.

“…The zoonotic Rift Valley fever virus (RVFV) can cause severe disease in humans and has pandemic potential, yet no approved vaccine or therapy exists. Here we…”
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Human Monoclonal Antibodies to Escherichia coli Outer Membrane Protein A Porin Domain Cause Aggregation but Do Not Alter In Vivo Bacterial Burdens in a Murine Sepsis Model by Fowler, Benjamin D, Kose, Nurgun, Reidy, Joseph X, Handal, Laura S, Skaar, Eric P, Crowe, Jr, James E

“…Escherichia coli is one of the most frequent human pathogens, increasingly exhibits antimicrobial resistance, and has complex interactions with the host immune…”
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Potent cross-neutralization of respiratory syncytial virus and human metapneumovirus through a structurally conserved antibody recognition mode by Wen, Xiaolin, Suryadevara, Naveenchandra, Kose, Nurgun, Liu, Jing, Zhan, Xiaoyan, Handal, Laura S., Williamson, Lauren E., Trivette, Andrew, Carnahan, Robert H., Jardetzky, Theodore S., Crowe, James E.

“…Respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) infections pose a significant health burden. Using pre-fusion conformation fusion…”
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Isolation of human antibodies against influenza B neuraminidase and mechanisms of protection at the airway interface by Wolters, Rachael M, Ferguson, James A, Nuñez, Ivette A, Chen, Elaine E, Sornberger, Ty, Myers, Luke, Oeverdieck, Svearike, Raghavan, Sai Sundar Rajan, Kona, Chandrahaas, Handal, Laura S, Esilu, Trevor E, Davidson, Edgar, Doranz, Benjamin J, Engdahl, Taylor B, Kose, Nurgun, Williamson, Lauren E, Creech, C Buddy, Gibson-Corley, Katherine N, Ward, Andrew B, Crowe, Jr, James E

“…Influenza B viruses (IBVs) comprise a substantial portion of the circulating seasonal human influenza viruses. Here, we describe the isolation of human…”
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Functional and structural basis of human parainfluenza virus type 3 neutralization with human monoclonal antibodies by Suryadevara, Naveenchandra, Otrelo-Cardoso, Ana Rita, Kose, Nurgun, Hu, Yao-Xiong, Binshtein, Elad, Wolters, Rachael M., Greninger, Alexander L., Handal, Laura S., Carnahan, Robert H., Moscona, Anne, Jardetzky, Theodore S., Crowe, James E.

“…Human parainfluenza virus type 3 (hPIV3) is a respiratory pathogen that can cause severe disease in older people and infants. Currently, vaccines against hPIV3…”
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Mechanistic basis for potent neutralization of Sin Nombre hantavirus by a human monoclonal antibody by Stass, Robert, Engdahl, Taylor B., Chapman, Nathaniel S., Wolters, Rachael M., Handal, Laura S., Diaz, Summer M., Crowe, James E., Bowden, Thomas A.

“…Rodent-borne hantaviruses are prevalent worldwide and upon spillover to human populations, cause severe disease for which no specific treatment is available. A…”
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Antigenic mapping and functional characterization of human New World hantavirus neutralizing antibodies by Engdahl, Taylor B, Binshtein, Elad, Brocato, Rebecca L, Kuzmina, Natalia A, Principe, Lucia M, Kwilas, Steven A, Kim, Robert K, Chapman, Nathaniel S, Porter, Monique S, Guardado-Calvo, Pablo, Rey, Félix A, Handal, Laura S, Diaz, Summer M, Zagol-Ikapitte, Irene A, Tran, Minh H, McDonald, W Hayes, Meiler, Jens, Reidy, Joseph X, Trivette, Andrew, Bukreyev, Alexander, Hooper, Jay W, Crowe, James E

“…Hantaviruses are high-priority emerging pathogens carried by rodents and transmitted to humans by aerosolized excreta or, in rare cases, person-to-person…”
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