Search Results - "Handa, Raj K"

Discovery of Novel PI3-Kinase δ Specific Inhibitors for the Treatment of Rheumatoid Arthritis: Taming CYP3A4 Time-Dependent Inhibition by Safina, Brian S, Baker, Stewart, Baumgardner, Matt, Blaney, Paul M, Chan, Bryan K, Chen, Yung-Hsiang, Cartwright, Matthew W, Castanedo, Georgette, Chabot, Christine, Cheguillaume, Arnaud J, Goldsmith, Paul, Goldstein, David M, Goyal, Bindu, Hancox, Timothy, Handa, Raj K, Iyer, Pravin S, Kaur, Jasmit, Kondru, Rama, Kenny, Jane R, Krintel, Sussie L, Li, Jun, Lesnick, John, Lucas, Matthew C, Lewis, Cristina, Mukadam, Sophie, Murray, Jeremy, Nadin, Alan J, Nonomiya, Jim, Padilla, Fernando, Palmer, Wylie S, Pang, Jodie, Pegg, Neil, Price, Steve, Reif, Karin, Salphati, Laurent, Savy, Pascal A, Seward, Eileen M, Shuttleworth, Stephen, Sohal, Sukhjit, Sweeney, Zachary K, Tay, Suzanne, Tivitmahaisoon, Parcharee, Waszkowycz, Bohdan, Wei, Binqing, Yue, Qin, Zhang, Chenghong, Sutherlin, Daniel P

“…PI3Kδ is a lipid kinase and a member of a larger family of enzymes, PI3K class IA(α, β, δ) and IB (γ), which catalyze the phosphorylation of PIP2 to PIP3…”
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Glucose transporters and glucose utilization in rat brain after acute ethanol administration by HANDA, Raj K, DEJOSEPH, Mary R, SINGH, Leela D, HAWKINS, Richard A, SINGH, Sant P

“…In the normal adult brain, glucose provides 90% of the energy requirements as well as substrate for nucleic acid and lipid synthesis. In the present study,…”
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Antithrombotic nipecotamide increases cyclic AMP levels and inhibits protein phosphorylation in human platelets by Handa, R K, Dillingham, E O, Gollamudi, R

“…alpha,alpha'-bis[3-(N,N-diethylcarbamoyl)piperidino]-p-xylene dihydrobromide (A-1), a typical antithrombotic nipecotamide, elevated the levels of cyclic…”
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Ligand-independent anti-oncogenic activity of the alpha subunit of the type I interferon receptor by Colamonici, O R, Porterfield, B, Domanski, P, Handa, R K, Flex, S, Samuel, C E, Pine, R, Diaz, M O

“…Two interferon (IFN) alpha-regulated genes, IRF1/ISGF2 and PKR/p68 kinase, may function as tumor suppressor genes suggesting that the IFN system may function…”
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Effects of ethanol on GLUT1 protein and gene expression in rat astrocytes by SINGH, L. D, SINGH, S. P, HANDA, R. K, EHMANN, S, SNYDER, A. K

“…Effects of ethanol on glucose transporter gene expression were examined in cultured rat astrocytes. Exposure to 50 or 100 mM ethanol for 18 hours significantly…”
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Reduced sarcolemmal dystrophin distribution and upregulation of utrophin in the cardiac and skeletal muscles of CHF-146 dystrophic hamsters by Bhattacharya, S K, Johnson, P L, Li, H J, Handa, R K, Adamec, T A

“…Abnormalities in the dystrophic gene product, dystrophin, have been implicated in initiating the primary membrane defect and excessive intracellular calcium…”
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The Effect of Ethanol on Muscarinic Receptor‐G Protein Coupling in the Rat Cortex by Singh, Sant P., Handa, Raj K., Depala, Vennugopal, Gao, Yan, Mcllroy, Patrick J., Ravindra, Rudravajhala

“…To understand the mechanism of ethanol action on G protein‐mediated signal transduction pathway, the effect of ethanol on muscarinic receptor‐G protein…”
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Antiplatelet effects of r, s-( meso)- α, α′- bis[3-( n , n-diethylcarbamoyl) piperidino]- p-xylene ex vivo in the dog and in vivo in the mouse by Han, Guozhu, Bannerman, Dana, Handa, Raj K., Dillingham, Elwood O., Lawrence, W.Homer, Gollamudi, Ram

“…1. 1. The nipecotamide α,α′-bis[3-(N,N-diethylcarbamoyl)piperidino]-p-xylene (A-1) is a platelet aggregation inhibitor. The meso diastereomer A-1c is superior…”
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