Search Results - "Handa, Naofumi"

MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex by Lee, Kyung Yong, Im, Jun-Sub, Shibata, Etsuko, Park, Jonghoon, Handa, Naofumi, Kowalczykowski, Stephen C., Dutta, Anindya

“…MCM8-9 complex is required for homologous recombination (HR)-mediated repair of double-strand breaks (DSBs). Here we report that MCM8-9 is required for DNA…”
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Reconstitution of initial steps of dsDNA break repair by the RecF pathway of E. coli by Handa, Naofumi, Morimatsu, Katsumi, Lovett, Susan T, Kowalczykowski, Stephen C

“…The RecF pathway of Escherichia coli is important for recombinational repair of DNA breaks and gaps. Here ;we reconstitute in vitro a seven-protein reaction…”
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Sae2 promotes DNA damage resistance by removing the Mre11–Rad50–Xrs2 complex from DNA and attenuating Rad53 signaling by Chen, Huan, Donnianni, Roberto A., Handa, Naofumi, Deng, Sarah K., Oh, Julyun, Timashev, Leonid A., Kowalczykowski, Stephen C., Symington, Lorraine S.

“…Significance Chromosomal double-strand breaks (DSBs) are cytotoxic forms of DNA damage that must be accurately repaired to maintain genome integrity. The…”
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Evolution in an oncogenic bacterial species with extreme genome plasticity: Helicobacter pylori East Asian genomes by Kawai, Mikihiko, Furuta, Yoshikazu, Yahara, Koji, Tsuru, Takeshi, Oshima, Kenshiro, Handa, Naofumi, Takahashi, Noriko, Yoshida, Masaru, Azuma, Takeshi, Hattori, Masahira, Uchiyama, Ikuo, Kobayashi, Ichizo

“…The genome of Helicobacter pylori, an oncogenic bacterium in the human stomach, rapidly evolves and shows wide geographical divergence. The high incidence of…”
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The Third Exon of the Budding Yeast Meiotic Recombination Gene HOP2 Is Required for Calcium-dependent and Recombinase Dmc1-specific Stimulation of Homologous Strand Assimilation by Chan, Yuen-Ling, Brown, M. Scott, Qin, Daoming, Handa, Naofumi, Bishop, Douglas K.

“…During meiosis in Saccharomyces cerevisiae, the HOP2 and MND1 genes are essential for recombination. A previous biochemical study has shown that budding yeast…”
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Molecular determinants responsible for recognition of the single-stranded DNA regulatory sequence, χ, by RecBCD enzyme by Handa, Naofumi, Yang, Liang, Dillingham, Mark S., Kobayashi, Ichizo, Wigley, Dale B., Kowalczykowski, Stephen C.

“…The RecBCD enzyme is important for both restriction of foreign DNA and recombinational DNA repair. Switching enzyme function from the destructive antiviral…”
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Birth and death of genes linked to chromosomal inversion by Furuta, Yoshikazu, Kawai, Mikihiko, Yahara, Koji, Takahashi, Noriko, Handa, Naofumi, Tsuru, Takeshi, Oshima, Kenshiro, Yoshida, Masaru, Azuma, Takeshi, Hattori, Masahira, Uchiyama, Ikuo, Kobayashi, Ichizo

“…The birth and death of genes is central to adaptive evolution, yet the underlying genome dynamics remain elusive. The availability of closely related complete…”
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Alteration of χ recognition by RecBCD reveals a regulated molecular latch and suggests a channel-bypass mechanism for biological control by Yang, Liang, Handa, Naofumi, Liu, Bian, Dillingham, Mark S., Wigley, Dale B., Kowalczykowski, Stephen C.

“…The RecBCD enzyme is a complex heterotrimeric helicase/nuclease that initiates recombination at double-stranded DNA breaks. In Escherichia coli, its activities…”
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Contribution of RecFOR machinery of homologous recombination to cell survival after loss of a restriction-modification gene complex by Handa, Naofumi, Ichige, Asao, Kobayashi, Ichizo

“…1 Laboratory of Social Genome Sciences, Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, 4-6-1 Shirokanedai,…”
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Hyperthermophilic DNA Methyltransferase M.PabI from the Archaeon Pyrococcus abyssi by Watanabe, Miki, Yuzawa, Harumi, Handa, Naofumi, Kobayashi, Ichizo

“…Genome sequence comparisons among multiple species of Pyrococcus, a hyperthermophilic archaeon, revealed a linkage between a putative restriction-modification…”
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Single Molecule Analysis of a Red Fluorescent RecA Protein Reveals a Defect in Nucleoprotein Filament Nucleation That Relates to Its Reduced Biological Functions by Handa, Naofumi, Amitani, Ichiro, Gumlaw, Nathan, Sandler, Steven J., Kowalczykowski, Stephen C.

“…Fluorescent fusion proteins are exceedingly useful for monitoring protein localization in situ or visualizing protein behavior at the single molecule level…”
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Maintenance Forced by a Restriction-Modification System Can Be Modulated by a Region in Its Modification Enzyme Not Essential for Methyltransferase Activity by Ohno, Satona, Handa, Naofumi, Watanabe-Matsui, Miki, Takahashi, Noriko, Kobayashi, Ichizo

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Genome-wide survey of mutual homologous recombination in a highly sexual bacterial species by Yahara, Koji, Kawai, Mikihiko, Furuta, Yoshikazu, Takahashi, Noriko, Handa, Naofumi, Tsuru, Takeshi, Oshima, Kenshiro, Yoshida, Masaru, Azuma, Takeshi, Hattori, Masahira, Uchiyama, Ikuo, Kobayashi, Ichizo

“…The nature of a species remains a fundamental and controversial question. The era of genome/metagenome sequencing has intensified the debate in prokaryotes…”
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Type III Restriction Is Alleviated by Bacteriophage (RecE) Homologous Recombination Function but Enhanced by Bacterial (RecBCD) Function by Handa, Naofumi, Kobayashi, Ichizo

“…ERRATUM ( vol. 189 , p. 1180 ) Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious…”
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Resection, as an important step of homologous recombination by Handa, Naofumi

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A DNA Methyltransferase Can Protect the Genome from Postdisturbance Attack by a Restriction-Modification Gene Complex by Takahashi, Noriko, Naito, Yasuhiro, Handa, Naofumi, Kobayashi, Ichizo

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Cellular Responses to Postsegregational Killing by Restriction-Modification Genes by Handa, N, Ichige, A, Kusano, K, Kobayashi, I

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Post-segregational killing by restriction modification gene complexes: Observations of individual cell deaths by Handa, Naofumi, Kobayashi, Ichizo

“…Through a mechanism known as post-segregational killing, several plasmids mediate their stable maintenance by carrying genes that kill plasmid-free segregant…”
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General sessions1A-04 Cleavage of a model DNA replication fork by restriction enzymes in vitro by ISHIKAWA Ken, HANDA Naofumi, KOBAYASHI Ichizo

“…DNA cleavage by a restriction enzyme is prevented by methylation on the recognition sequence. It has been imagined that DNA replication and restriction…”
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Multiplication of a restriction–modification gene complex by Sadykov, Marat, Asami, Yasuo, Niki, Hironori, Handa, Naofumi, Itaya, Mitsuhiro, Tanokura, Masaru, Kobayashi, Ichizo

“…Summary Previous works have suggested that some gene complexes encoding a restriction (R) enzyme and a cognate modification (M) enzyme may behave as selfish…”
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