Search Results - "Hand, Karen M."

Antioxidant-based inhibitors of leukotriene biosynthesis. The discovery of 6-[1-[2-(hydroxymethyl)phenyl]-1-propen-3-yl]-2,3-dihydro-5-benzofuranol, a potent topical antiinflammatory agent by Hammond, Milton L, Zambias, Robert A, Chang, Michael N, Jensen, Norman P, McDonald, John, Thompson, Kathryn, Boulton, David A, Kopka, Ihor E, Hand, Karen M

“…The leukotrienes, metabolites of arachidonic acid produced through the action of the enzyme 5-lipoxygenase, are important mediators of immediate…”
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Orally Active .beta.-Lactam Inhibitors of Human Leukocyte Elastase. 3. Stereospecific Synthesis and Structure-Activity Relationships for 3,3-Dialkylazetidin-2-ones by Finke, Paul E, Shah, Shrenik K, Fletcher, Daniel S, Ashe, Bonnie M, Brause, Karen A, Chandler, Gilbert O, Dellea, Pam S, Hand, Karen M, Maycock, Alan L

“…The stereospecific synthesis of several 4-[(4-carboxyphenyl)oxy]- 3,3-dialkyl-1-[[(1-phenylalkyl)-amino]carbonyl]azetidin-2-on es 3 is described in which the…”
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Orally active .beta.-lactam inhibitors of human leukocyte elastase-1. Activity of 3,3-diethyl-2-azetidinones by Shah, Shrenik K, Dorn, Conrad P, Finke, Paul E, Hale, Jeffrey J, Hagmann, William K, Brause, Karen A, Chandler, Gilbert O, Kissinger, Amy L, Ashe, Bonnie M

“…A thorough analysis of the mechanism of inhibition of human leukocyte elastase (HLE) by a monocyclic beta-lactam and the mechanism of beta-lactam hydrolysis…”
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Chemical, Biochemical, Pharmacokinetic, and Biological Properties of L-680, 833: A Potent, Orally Active Monocyclic β-Lactam Inhibitor of Human Polymorphonuclear Leukocyte Elastase by Doherty, James B., Shah, Shrenik K., Finke, Paul E., Dorn, Conrad P., Hagmann, William K., Hale, Jeffrey J., Kissinger, Amy L., Thompson, Kevan R., Brause, karen, Chandler, Gilbert O., Knight, Wilson B., Maycock, Alan L., Ashe, Bonnie M., Weston, Hazel, Gale, Paul, Mumford, Richard A., Andersen, O. Frederick, Williams, Hollis R., Nolan, Thomas E., Frankenfield, Dale L., Underwood, Dennis, Vyas, Kamlesh P., Kari, Prasad H., Dahlgren, Mary E., Mao, Jennifer, Fletcher, Daniel S., Pa. S. Dellea, Hand, Karen M., Osinga, Donald G., Peterson, Laurence B., Williams, Dorsey T., Metzger, Joseph M., Bonney, Robert J., Humes, John L., Pacholok, Steven P., Hanlon, William A., Opas, Evan, Stolk, Jan, Davies, Philip

“…A series of potent and highly selective time-dependent monocyclic β-lactam inhibitors of human polymorphonuclear leukocyte elastase (PMNE, EC 3.4.21.37) is…”
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Inhibition of human leukocyte elastase. 4. Selection of a substituted cephalosporin (L-658,758) as a topical aerosol by Finke, Paul E, Shah, Shrenik K, Ashe, Bonnie M, Ball, Richard G, Blacklock, Thomas J, Bonney, Robert J, Brause, Karen A, Chandler, Gilbert O, Cotton, Meredith

“…Human leukocyte elastase (HLE) is a serine protease which has been implicated as a causative agent in several pulmonary diseases. The continued modification of…”
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Orally active .beta.-lactam inhibitors of human leukocyte elastase. 2. Effect of C-4 substitution by Hagmann, William K, Kissinger, Amy L, Shah, Shrenik K, Finke, Paul E, Dorn, Conrad P, Brause, Karen A, Ashe, Bonnie M, Weston, Hazel, Maycock, Alan L

“…The effect of changing the C-4 substituent of 3,3-diethyl-1-[(benzylamino)carbonyl]-2-azetidinone on inhibition of HLE and in a model of HLE-induced lung…”
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The effects of mevinolin on serum cholesterol levels of rabbits with endogenous hypercholesterolemia by Kroon, P A, Hand, K M, Huff, J W, Alberts, A W

“…Mevinolin, a fungal metabolite isolated from cultures of Aspergillus terreus, is a potent competitive inhibitor of 3-hydroxy-3-methyl glutaryl coenzyme A…”
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A comparison of alpha 1-proteinase inhibitor methoxysuccinyl-Ala-Ala-Pro-Val-chloromethylketone and specific beta-lactam inhibitors in an acute model of human polymorphonuclear leukocyte elastase-induced lung hemorrhage in the hamster by Fletcher, D S, Osinga, D G, Hand, K M, Dellea, P S, Ashe, B M, Mumford, R A, Davies, P, Hagmann, W, Finke, P E, Doherty, J B

“…A pharmacokinetic model is described for testing of polymorphonuclear leukocyte (PMN) elastase inhibitors administered by intratracheal or aerosol dosing of…”
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Inhibitory effects of alkyl 2-cyanoacrylate tissue adhesives on rat liver cytoplasm preparations by McTernan, M B, Hand, K M, Braun, G A, Siegmund, E A, Willigan, D A

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